Mechanotransduction and extracellular matrix homeostasis

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(12), P. 802 - 812

Published: Oct. 22, 2014

Language: Английский

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Integrins as biomechanical sensors of the microenvironment

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(8), P. 457 - 473

Published: June 10, 2019

Language: Английский

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Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

Nature Materials, Journal Year: 2014, Volume and Issue: 13(6), P. 558 - 569

Published: May 21, 2014

Language: Английский

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Interplay of matrix stiffness and protein tethering in stem cell differentiation

Nature Materials, Journal Year: 2014, Volume and Issue: 13(10), P. 979 - 987

Published: Aug. 8, 2014

Language: Английский

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Integrin-mediated mechanotransduction

The Journal of Cell Biology, Journal Year: 2016, Volume and Issue: 215(4), P. 445 - 456

Published: Nov. 8, 2016

Cells can detect and react to the biophysical properties of extracellular environment through integrin-based adhesion sites adapt milieu in a process called mechanotransduction. At these sites, integrins connect matrix (ECM) with F-actin cytoskeleton transduce mechanical forces generated by actin retrograde flow myosin II ECM mechanosensitive focal proteins that are collectively termed “molecular clutch.” The transmission across adhesions establishes reciprocity between viscoelasticity cellular tension. During mechanotransduction, force allosterically alters functions within elicit biochemical signals regulate both rapid responses mechanics long-term changes gene expression. Integrin-mediated mechanotransduction plays important roles development tissue homeostasis, its dysregulation is often associated diseases.

Language: Английский

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YAP/TAZ upstream signals and downstream responses

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(8), P. 888 - 899

Published: July 19, 2018

Language: Английский

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Role of the extracellular matrix in regulating stem cell fate

Nature Reviews Molecular Cell Biology, Journal Year: 2013, Volume and Issue: 14(8), P. 467 - 473

Published: July 10, 2013

Language: Английский

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Appreciating force and shape — the rise of mechanotransduction in cell biology

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(12), P. 825 - 833

Published: Oct. 30, 2014

Language: Английский

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Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

Nature Cell Biology, Journal Year: 2016, Volume and Issue: 18(5), P. 540 - 548

Published: April 11, 2016

Language: Английский

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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(20), P. 12764 - 12850

Published: Oct. 9, 2017

The cell microenvironment has emerged as a key determinant of behavior and function in development, physiology, pathophysiology. extracellular matrix (ECM) within the serves not only structural foundation for cells but also source three-dimensional (3D) biochemical biophysical cues that trigger regulate behaviors. Increasing evidence suggests 3D character is required development many critical responses observed vivo, fueling surge functional biomimetic materials engineering microenvironment. Progress design such improved control behaviors advanced fields tissue regeneration, vitro models, large-scale differentiation, immunotherapy, gene therapy. However, field still its infancy, discoveries about nature cell–microenvironment interactions continue to overturn much early progress field. Key challenges be dissecting roles chemistry, structure, mechanics, electrophysiology microenvironment, understanding harnessing periodicity drift these factors. This review encapsulates where recent advances appear leave ever-shifting state art, it highlights areas which substantial potential uncertainty remain.

Language: Английский

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