Oxidative Stress

Annual Review of Biochemistry, Journal Year: 2017, Volume and Issue: 86(1), P. 715 - 748

Published: April 25, 2017

Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecules, maintenance of a physiological level challenge, termed oxidative eustress, essential for governing life processes through redox signaling. Recent interest has focused on the intricate ways by which signaling integrates these converse properties. Redox balance maintained prevention, interception, and repair, concomitantly regulatory potential molecular thiol-driven master switches such as Nrf2/Keap1 or NF-κB/IκB used system-wide response. Nonradical species hydrogen peroxide (H2O2) singlet oxygen, rather than free-radical species, perform major second messenger functions. Chemokine-controlled NADPH oxidases metabolically controlled mitochondrial sources H2O2 well glutathione- thioredoxin-related pathways, with powerful enzymatic back-up systems, are responsible fine-tuning This makes rich research field spanning from biochemistry cell biology into nutritional sciences, environmental medicine, knowledge-based medicine.

Language: Английский

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Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Redox Biology, Journal Year: 2017, Volume and Issue: 11, P. 613 - 619

Published: Jan. 5, 2017

Hydrogen peroxide emerged as major redox metabolite operative in sensing, signaling and regulation. Generation, transport capture of H2O2 biological settings well their consequences can now be addressed. The present overview focuses on recent progress metabolic sources sinks the role under physiological conditions (1–10 nM), denoted oxidative eustress. Higher concentrations lead to adaptive stress responses via master switches such Nrf2/Keap1 or NF-κB. Supraphysiological (>100 nM) damage biomolecules, distress. Three questions are addressed: How assayed setting? What H2O2? is stress?

Language: Английский

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Antioxidant responses and cellular adjustments to oxidative stress

Redox Biology, Journal Year: 2015, Volume and Issue: 6, P. 183 - 197

Published: July 21, 2015

Redox biological reactions are now accepted to bear the Janus faceted feature of promoting both physiological signaling responses and pathophysiological cues. Endogenous antioxidant molecules participate in scenarios. This review focuses on role crucial cellular nucleophiles, such as glutathione, their capacity interact with oxidants establish networks other critical enzymes peroxiredoxins. We discuss importance Nrf2-Keap1 pathway an example a transcriptional response we summarize routes related redox activation. As examples tissular settings where major players highlight endoplasmic reticulum stress ischemia reperfusion. Topologically confined redox-mediated post-translational modifications thiols considered important molecular mechanisms mediating many responses, whereas redox-sensitive microRNAs have emerged key posttranscriptional regulation gene expression. Understanding may provide basis for antioxidant-based therapeutic interventions redox-related diseases.

Language: Английский

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Neutrophil migration in infection and wound repair: going forward in reverse

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(6), P. 378 - 391

Published: May 27, 2016

Language: Английский

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Advances in skin grafting and treatment of cutaneous wounds

Science, Journal Year: 2014, Volume and Issue: 346(6212), P. 941 - 945

Published: Nov. 20, 2014

The ability of the skin to repair itself after injury is vital human survival and disrupted in a spectrum disorders. process cutaneous wound healing complex, requiring coordinated response by immune cells, hematopoietic resident cells skin. We review classic paradigms evaluate how recent discoveries have enriched our understanding this process. current experimental approaches treating wounds, with an emphasis on cell-based therapies transplantation.

Language: Английский

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Role of Metabolic H2O2 Generation

Journal of Biological Chemistry, Journal Year: 2014, Volume and Issue: 289(13), P. 8735 - 8741

Published: Feb. 11, 2014

Language: Английский

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The Redox Code

Antioxidants and Redox Signaling, Journal Year: 2015, Volume and Issue: 23(9), P. 734 - 746

Published: April 19, 2015

Significance: The redox code is a set of principles that defines the positioning nicotinamide adenine dinucleotide (NAD, NADP) and thiol/disulfide other systems as well thiol proteome in space time biological systems. richly elaborated an oxygen-dependent life, where activation/deactivation cycles involving O2 H2O2 contribute to spatiotemporal organization for differentiation, development, adaptation environment. Disruption this organizational structure during oxidative stress represents fundamental mechanism system failure disease. Recent Advances: Methodology assessing components under physiological conditions has progressed, permitting insight into allowing identification partners proteomics metabolomics. Critical Issues: Complexity networks regulation being revealed step by step, yet much still needs be learned. Future Directions: Detailed knowledge molecular patterns generated from defined or pathological cells organs will understanding component health Ultimately, there scientific basis modern medicine. Antioxid. Redox Signal. 23, 734–746.

Language: Английский

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Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(24), P. 11707 - 11794

Published: Dec. 14, 2018

Cellular signaling networks are the foundation which determines fate and function of cells as they respond to various cues stimuli. The discovery fluorescent proteins over 25 years ago enabled development a diverse array genetically encodable biosensors that capable measuring spatiotemporal dynamics signal transduction pathways in live cells. In an effort encapsulate breadth have expanded, we endeavored assemble comprehensive list published engineered biosensors, discuss many molecular designs utilized their development. Then, review how high temporal spatial resolution afforded by has aided our understanding regulation at cellular subcellular level. Finally, highlight some emerging areas research both biosensor design applications on forefront

Language: Английский

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Forces driving epithelial wound healing

Nature Physics, Journal Year: 2014, Volume and Issue: 10(9), P. 683 - 690

Published: Aug. 3, 2014

Language: Английский

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Soft tissue wound healing around teeth and dental implants

Journal Of Clinical Periodontology, Journal Year: 2014, Volume and Issue: 41(s15)

Published: March 19, 2014

Abstract Aim To provide an overview on the biology and soft tissue wound healing around teeth dental implants. Material Methods This narrative review focuses cell histology of wounds natural Results conclusions The available data indicate that: Oral follow a similar pattern. specificities gingival, alveolar palatal mucosa appear to be innately not necessarily functionally determined. granulation originating from periodontal ligament or connective originally covered by keratinized epithelium has potential induce keratinization. However, it also appears that deep may have same keratinization as immediately subepithelial area. Epithelial following non‐surgical surgical therapy completed after period 7–14 days. Structural integrity maturing between denuded root surface flap is achieved at approximately 14‐days post‐surgery. formation biological width maturation barrier function transmucosal implants requires 6–8 weeks healing. established peri‐implant resembles scar in composition, fibre orientation, vasculature. junctional reach greater final length under certain conditions such placed into fresh extraction sockets versus conventional implant procedures healed sites.

Language: Английский

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