The Role of Bacterial Biofilm in Antibiotic Resistance and Food Contamination

International Journal of Microbiology, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 10

Published: Aug. 25, 2020

Biofilm is a microbial association or community attached to different biotic abiotic surfaces environments. These surface-attached communities can be found in food, medical, industrial, and natural critical problem the medical sector since it formed on implants within human tissue involved multitude of serious chronic infections. Food food processing surface become an ideal environment for biofilm formation where there are sufficient nutrients growth attachment. Therefore, these surfaces, especially becomes challenge safety health. Microorganisms encased matrix extracellular polymeric substances that act as barrier recalcitrant hostile conditions such sanitizers, antibiotics, other hygienic conditions. Generally, they persist exist environments source cross-contamination foodborne diseases. The issue with their antibiotic resistance which makes medication difficult, use physical, physiological, gene-related factors develop mechanisms. In order mitigate production controlling methods, better understand requirements aim this review article provide overview role bacterial biofilms contamination emphasizes ways its production.

Language: Английский

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Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 369 - 369

Published: Feb. 1, 2023

This review highlights the different modes of synthesizing silver nanoparticles (AgNPs) from their elemental state to particle format and mechanism action against multidrug-resistant biofilm-forming bacterial pathogens. Various studies have demonstrated that AgNPs cause oxidative stress, protein dysfunction, membrane disruption, DNA damage in bacteria, ultimately leading death. also been found alter adhesion cells prevent biofilm formation. The benefits using medicine are, some extent, counter-weighted by toxic effect on humans environment. In this review, we compiled recent demonstrating antibacterial activity AgNPs, are discussing known mechanisms Ongoing clinical trials involving briefly presented. A particular focus is placed interaction with biofilms, which a significant pathogenicity determinant. brief overview use other medical applications (e.g., diagnostics, promotion wound healing) non-medical sectors Finally, current drawbacks limitations discussed, perspectives for improved future functionalized

Language: Английский

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Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 4389 - 4401

Published: April 30, 2021

Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic treatment by pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. SASs/NPC stronger peroxidase-like activity, glutathione (GSH)-depleting function, photothermal property compared non-Cu-doped NPC, indicating that doping significantly improves the performance nanozymes. can effectively induce in presence H

Language: Английский

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Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

Advanced Science, Journal Year: 2021, Volume and Issue: 8(19)

Published: Aug. 5, 2021

Healthcare-acquired infections as well increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene attracted great interest, particular, the emergence of surface design strategies offer effective antibiotics, thereby preventing possible development resistance. In this review, recent progress on advanced modifications prevent addressed comprehensively, starting with key factors against adhesion, followed by varying that can inhibit biofilm formation effectively. Furthermore, "super antibacterial systems" through pre-treatment defense targeted bactericidal system, proposed evidence clinical potential. Finally, advantages future challenges resist healthcare-associated discussed, promising prospects developing novel materials.

Language: Английский

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Antimicrobial Metal Nanomaterials: From Passive to Stimuli‐Activated Applications

Advanced Science, Journal Year: 2020, Volume and Issue: 7(10)

Published: April 6, 2020

The development of antimicrobial drug resistance among pathogenic bacteria and fungi is one the most significant health issues 21st century. Recently, advances in nanotechnology have led to nanomaterials, particularly metals that exhibit properties. These metal nanomaterials emerged as promising alternatives traditional therapies. In this review, a broad overview their synthesis, properties, interactions with micro-organisms first provided. Secondly, range demonstrate passive properties are outlined in-depth analysis comparison stimuli-responsive provided, which represent next generation microbiocidal nanomaterials. stimulus applied activate such includes light (including photocatalytic photothermal) magnetic fields, can induce hyperthermia kinetically driven activation. Broadly, review aims summarize currently available research provide future scope for nanomaterial-based technologies, those be activated through externally stimuli.

Language: Английский

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