Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

Advanced Science, Journal Year: 2021, Volume and Issue: 8(19)

Published: Aug. 5, 2021

Healthcare-acquired infections as well increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene attracted great interest, particular, the emergence of surface design strategies offer effective antibiotics, thereby preventing possible development resistance. In this review, recent progress on advanced modifications prevent addressed comprehensively, starting with key factors against adhesion, followed by varying that can inhibit biofilm formation effectively. Furthermore, "super antibacterial systems" through pre-treatment defense targeted bactericidal system, proposed evidence clinical potential. Finally, advantages future challenges resist healthcare-associated discussed, promising prospects developing novel materials.

Language: Английский

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Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Language: Английский

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Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications

Advanced Science, Journal Year: 2022, Volume and Issue: 9(13)

Published: Feb. 27, 2022

Infections are regarded as the most severe complication associated with human health, which urgent to be solved. Stimuli-responsive materials appealing therapeutic platforms for antibacterial treatments, provide great potential accurate theranostics. In this review, advantages, response mechanisms, and key design principles of stimuli-responsive highlighted. The biomedical applications, current challenges, future directions also discussed. First, categories comprehensively itemized based on different sources stimuli, including external physical environmental stimuli (e.g., temperature, light, electricity, salt, etc.) bacterial metabolites acid, enzyme, redox, etc.). Second, structural characteristics, principles, applications responsive discussed, underlying interrelationships revealed. molecular structures closely related stimuli. Finally, challenging issues proposed. This review will scientific guidance promote clinical materials.

Language: Английский

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Bioadhesive Technology Platforms

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 14084 - 14118

Published: Nov. 16, 2023

Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease minimal damage. These materials present numerous opportunities for tissue repair biomedical device integration, creating a broad landscape of applications that captivated clinical scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, efficient signal communication. In this Review, we delve into these pivotal aspects bioadhesive design, highlight latest advances applications, identify lie ahead bioadhesives multifunctional technology platforms.

Language: Английский

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Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

The Innovation, Journal Year: 2023, Volume and Issue: 4(6), P. 100503 - 100503

Published: Aug. 29, 2023

•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.

Language: Английский

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Potent antibiotic design via guided search from antibacterial activity evaluations

Bioinformatics, Journal Year: 2023, Volume and Issue: 39(2)

Published: Jan. 27, 2023

Abstract Motivation The emergence of drug-resistant bacteria makes the discovery new antibiotics an urgent issue, but finding molecules with desired antibacterial activity is extremely difficult task. To address this challenge, we established a framework, MDAGS (Molecular Design via Attribute-Guided Search), to optimize and generate potent antibiotic molecules. Results By designing latent space guiding optimization functional compounds based on space, model can novel desirable without need for extensive expensive time-consuming evaluations. Compared existing antibiotics, candidate generated by always possessed significantly better ensured high similarity. Furthermore, although explicit constraints similarity known these all exhibited highest structural expected function in DrugBank database query. Overall, our approach provides viable solution problem bacterial drug resistance. Availability implementation Code datasets be downloaded from GitHub (https://github.com/LiangYu-Xidian/MDAGS). Supplementary information data are available at Bioinformatics online.

Language: Английский

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Recent advance in biomass membranes: Fabrication, functional regulation, and antimicrobial applications

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 305, P. 120537 - 120537

Published: Jan. 5, 2023

Language: Английский

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Surface antibacterial properties enhanced through engineered textures and surface roughness: A review

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 231, P. 113584 - 113584

Published: Oct. 10, 2023

The spread of bacteria through contaminated surfaces is a major issue in healthcare, food industry, and other economic sectors. widespread use antibiotics not sustainable solution the long term due to development antibiotic resistance. Therefore, with antibacterial properties have potential be disruptive approach combat microbial contamination. Different methods approaches been studied impart or enhance on surfaces. surface roughness texture are inherent parameters that significantly impact surface. They also directly related previously employed machining treatment methods. This review article discusses correlation between presented discussed. It begins an introduction concepts texture, followed by description most commonly utilized A thorough analysis bacterial adhesion growth then presented. Finally, recent studies this research area comprehensively reviewed. sorted classified based methods, which divided into mechanical processes, treatments coatings. Through systematic record advances, authors aim assist promote further very promising extremely important direction, providing advances.

Language: Английский

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Fit and forget: The future of dental implant therapy via nanotechnology

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114900 - 114900

Published: May 30, 2023

Unlike orthopedic implants, dental implants require the orchestration of both osseointegration at bone-implant interface and soft-tissue integration transmucosal region in a complex oral micro-environment with ubiquitous pathogenic bacteria. This represents very challenging environment for early acceptance long-term survival especially compromised patient conditions, including aged, smoking diabetic patients. Enabling advanced local therapy from surface titanium-based via novel nano-engineering strategies is emerging. includes anodized nano-engineered eluting growth factors, antibiotics, therapeutic nanoparticles biopolymers to achieve maximum localized action. An important criterion balancing bioactivity enhancement (like bactericidal efficacy) without causing cytotoxicity. Critical research gaps still need be addressed enable clinical translation these implants. review informs latest developments, challenges future directions this domain successful fabrication clinically-translatable that would allow success, even conditions.

Language: Английский

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

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