Proceedings of the National Academy of Sciences,
Journal Year:
2019,
Volume and Issue:
116(17), P. 8582 - 8590
Published: April 8, 2019
Significance
The
primary
finding
in
this
study
was
the
dramatic
association
of
brain
resting-state
network
(RSN)
connectivity
abnormalities
with
a
history
childhood
trauma
major
depressive
disorder
(MDD).
Even
though
participants
were
not
selected
for
and
imaging
took
place
decades
after
occurrence,
scar
prior
evident
functional
dysconnectivity.
In
addition
to
trauma,
dimensions
MDD
symptoms
related
abnormal
connectivity.
Further,
we
found
that
model
described
within-
between-network
differences
from
controls
multiple
RSNs,
including
default
mode
network,
frontoparietal
attention
sensory
systems.
JAMA Psychiatry,
Journal Year:
2019,
Volume and Issue:
76(6), P. 584 - 584
Published: March 20, 2019
Childhood
maltreatment
is
associated
with
mental
illness.
Researchers,
clinicians,
and
public
health
professionals
use
prospective
or
retrospective
measures
interchangeably
to
assess
childhood
maltreatment,
assuming
that
the
2
identify
same
individuals.
However,
this
assumption
has
not
been
comprehensively
tested.To
meta-analyze
agreement
between
of
maltreatment.MEDLINE,
PsycINFO,
Embase,
Sociological
Abstracts
were
searched
for
peer-reviewed,
English-language
articles
from
inception
through
January
1,
2018.
Search
terms
included
child*
abuse,
neglect,
child
bull*,
trauma,
advers*,
early
life
stress
combined
prospective*
cohort.Studies
first
selected.
Among
selected
studies,
those
corresponding
identified.
Of
450
studies
16
had
paired
data
compute
Cohen
κ
coefficient.Multiple
investigators
independently
extracted
according
PRISMA
MOOSE
guidelines.
Random-effects
meta-analyses
used
pool
results
test
predictors
heterogeneity.The
primary
outcome
was
expressed
as
a
coefficient.
Moderators
priori
measure
assessment
age
at
report,
sample
size,
sex
distribution,
study
quality.Sixteen
unique
including
25
471
participants
(52.4%
female
[SD,
10.6%];
mean
[SD]
age,
30.6
[11.6]
years)
contained
on
maltreatment.
The
poor,
=
0.19
(95%
CI,
0.14-0.24;
P
<
.001).
Agreement
higher
when
based
interviews
rather
than
questionnaires
(Q
4.1521;
df
1;
.04)
in
smaller
samples
4.2251;
.04).
affected
by
type
used,
distribution
sample,
quality.Prospective
different
groups
Therefore,
children
identified
prospectively
having
experienced
may
have
risk
pathways
illness
adults
retrospectively
reporting
care
should
recognize
these
critical
measurement
differences
conducting
research
into
developing
interventions.
Annual Review of Developmental Psychology,
Journal Year:
2019,
Volume and Issue:
1(1), P. 277 - 312
Published: Dec. 13, 2019
An
extensive
literature
on
childhood
adversity
and
neurodevelopment
has
emerged
over
the
past
decade.
We
evaluate
two
conceptual
models
of
neurodevelopment—the
dimensional
model
stress
acceleration
model—in
a
systematic
review
109
studies
using
MRI-based
measures
neural
structure
function
in
children
adolescents.
Consistent
with
model,
exposed
to
threat
had
reduced
amygdala,
medial
prefrontal
cortex
(mPFC),
hippocampal
volume
heightened
amygdala
activation
majority
studies;
these
patterns
were
not
observed
consistently
deprivation.
In
contrast,
altered
frontoparietal
regions
deprivation
but
threat.
Evidence
for
accelerated
development
amygdala-mPFC
circuits
was
limited
other
metrics
neurodevelopment.
Progress
charting
neurodevelopmental
consequences
requires
larger
samples,
longitudinal
designs,
more
precise
assessments
adversity.
BMJ,
Journal Year:
2020,
Volume and Issue:
unknown, P. m3048 - m3048
Published: Oct. 28, 2020
The
prevalence
of
"toxic
stress"
and
huge
downstream
consequences
in
disease,
suffering,
financial
costs
make
prevention
early
intervention
crucial,
say
Charles
A
Nelson
colleagues
American Journal of Psychiatry,
Journal Year:
2019,
Volume and Issue:
177(1), P. 20 - 36
Published: Sept. 20, 2019
A
large
body
of
evidence
has
demonstrated
that
exposure
to
childhood
maltreatment
at
any
stage
development
can
have
long-lasting
consequences.
It
is
associated
with
a
marked
increase
in
risk
for
psychiatric
and
medical
disorders.
This
review
summarizes
the
literature
investigating
effects
on
disease
vulnerability
mood
disorders,
specifically
summarizing
cross-sectional
more
recent
longitudinal
studies
demonstrating
prevalent
increased
first
episode,
episode
recurrence,
greater
comorbidities,
suicidal
ideation
attempts
individuals
persistent
alterations
maltreatment,
including
hypothalamic-pituitary-adrenal
axis
inflammatory
cytokines,
which
may
contribute
pernicious
course.
The
authors
discuss
several
candidate
genes
environmental
factors
(for
example,
substance
use)
alter
illness
course
neurobiological
associations
mediate
these
relationships
following
maltreatment.
Studies
provide
insight
into
modifiable
mechanisms
direction
improve
both
treatment
prevention
strategies.
Jornal de Pediatria,
Journal Year:
2020,
Volume and Issue:
97(4), P. 369 - 377
Published: Sept. 23, 2020
This
was
a
systematic
review
of
studies
that
examined
the
impact
epidemics
or
social
restriction
on
mental
and
developmental
health
in
parents
children/adolescents.The
PubMed,
WHO
COVID-19,
SciELO
databases
were
searched
March
15,
2020,
April
25,
filtering
for
children
(0-18
years)
humans.The
tools
used
to
mitigate
threat
pandemic
such
as
COVID-19
may
very
well
threaten
child
growth
development.
These
-
restrictions,
shutdowns,
school
closures
contribute
stress
can
become
risk
factors
development
compromise
Sustainable
Development
Goals.
The
reviewed
suggest
lead
high
levels
children,
which
begin
with
concerns
about
becoming
infected.
describe
several
potential
emotional
consequences
H1N1,
AIDS,
Ebola:
severe
anxiety
depression
among
acute
disorder,
post-traumatic
stress,
disorders,
children.
data
be
related
adverse
childhood
experiences
elevated
toxic
stress.
more
experiences,
greater
delays
problems
adulthood,
cognitive
impairment,
substance
abuse,
depression,
non-communicable
diseases.Information
is
relevant
policy
makers
aid
them
developing
strategies
help
families
cope
epidemic/pandemic-driven
adversity
ensure
their
children's
healthy
Frontiers in Psychiatry,
Journal Year:
2019,
Volume and Issue:
10
Published: March 11, 2019
Early
life
stressors
display
a
high
universal
prevalence
and
constitute
major
public
health
problem.
Prolonged
psychoneurobiological
alterations
as
sequelae
of
early
stress
(ELS)
could
represent
developmental
risk
factor
mediate
for
disease,
leading
to
higher
physical
mental
morbidity
rates
in
later
life.
ELS
exert
programming
effect
on
sensitive
neuronal
brain
networks
related
the
response
during
critical
periods
development
thus
lead
enduring
hyper-
or
hypo-activation
system
altered
glucocorticoid
signaling.
In
addition,
emotional
autonomic
reactivity,
circadian
rhythm
disruption,
functional
structural
changes
brain,
well
immune
metabolic
dysregulation
have
been
lately
identified
important
factors
chronically
impaired
homeostatic
balance
after
ELS.
Furthermore,
human
genetic
background
epigenetic
modifications
through
stress-related
gene
expression
interact
with
these
explain
inter-individual
variation
vulnerability
resilience
stress.
This
narrative
review
presents
relevant
evidence
from
mainly
research
ten
most
acknowledged
neurobiological
allostatic
pathways
exerting
adverse
effects
even
decades
(hypothalamic-pituitary-adrenal
axis,
nervous
system,
inflammation,
oxidative
stress,
cardiovascular
gut
microbiome,
sleep
genetics,
epigenetics,
structural,
correlates).
Although
findings
back
causal
relation
between
psychobiological
maladjustment
life,
precise
trajectories
their
temporal
coincidence
has
not
elucidated
yet.
Future
studies
should
prospectively
investigate
putative
mediators
sequence,
while
considering
potentially
delayed
time-frame
phenotypical
expression.
Better
screening
strategies
are
needed
better
individual
prevention
treatment.