The relationship between sleep disturbance and cognitive impairment in mood disorders: A systematic review

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 327, P. 207 - 216

Published: Feb. 3, 2023

Cognitive impairment experienced by people with bipolar disorders (BD) or major depressive disorder (MDD) is associated impaired psychosocial function and poorer quality of life. Sleep disturbance another core symptom mood which may be with, perhaps worsen, cognitive impairments. The aim this systematic review was to critically assess the relationship between sleep in disorders.In review, relevant studies were identified using electronic database searches PsychINFO, MEDLINE, Embase Web Science.Fourteen included; eight investigated BD, five MDD, one included both MDD BD. One study an intervention for remaining thirteen used either a longitudinal cross-sectional observational design. Ten reported significant association subjectively measured BD after adjusting demographic clinical covariates, whereas no such found healthy participants. Two objectively (actigraphy polysomnography) abnormalities disorders. behavioural therapy insomnia modified (CBTI-BD) improvements performance BD.There preliminary evidence suggest These findings highlight need further research disturbances

Language: Английский

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The consequences of sleep deprivation on cognitive performance

Neurosciences, Journal Year: 2023, Volume and Issue: 28(2), P. 91 - 99

Published: April 1, 2023

Although not fully understood, sleep is accepted as a vital and organized sequence of events that follows regular cyclic program each night to ensure the human body can perform at its optimum. A lack sleep, or deprivation (SD), widespread phenomenon induce adverse changes in cognitive performance. This review focused on biological explanation well research investigating numerous effects SD have cognition. reduction does occur independently memory, attention, alertness, judgment, decision-making, overall abilities brain, resulting decreased function impaired

Language: Английский

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Adenotonsillectomy for Snoring and Mild Sleep Apnea in Children

JAMA, Journal Year: 2023, Volume and Issue: 330(21), P. 2084 - 2084

Published: Dec. 5, 2023

Importance The utility of adenotonsillectomy in children who have habitual snoring without frequent obstructive breathing events (mild sleep-disordered [SDB]) is unknown. Objectives To evaluate early compared with watchful waiting and supportive care (watchful waiting) on neurodevelopmental, behavioral, health, polysomnographic outcomes mild SDB. Design, Setting, Participants Randomized clinical trial enrolling 459 aged 3 to 12.9 years an apnea-hypopnea index (AHI) less than enrolled at 7 US academic sleep centers from June 29, 2016, February 1, 2021, followed up for 12 months. Intervention were randomized 1:1 either (n = 231) or 228). Main Outcomes Measures 2 primary changes baseline months caregiver-reported Behavior Rating Inventory Executive Function (BRIEF) Global Composite (GEC) T score, a measure executive function; computerized test attention, the Go/No-go (GNG) d-prime signal detection reflecting probability response target vs nontarget stimuli. Twenty-two secondary included 12-month quality life, sleep, health outcomes. Results Of 458 participants analyzed sample (231 237 waiting; mean age, 6.1 years; 230 female [50%]; 123 Black/African American [26.9%]; 75 Hispanic [16.3%]; median AHI, 0.5 [IQR, 0.2-1.1]), 394 (86%) completed follow-up visits. There no statistically significant differences change between groups function (BRIEF GEC T-scores: −3.1 −1.9 difference, −0.96 [95% CI, −2.66 0.74]) attention (GNG scores: 0.2 0.1 0.05 −0.18 0.27]) Behavioral problems, sleepiness, symptoms, life each improved more waiting. Adenotonsillectomy was associated greater decline systolic diastolic blood pressure percentile levels (difference changes, −9.02 [97% −15.49 −2.54] −6.52 −11.59 −1.45], respectively) progression AHI events/h (1.3% group 13.2% group; −11.2% −17.5% −4.9%]). Six (2.7%) experienced serious adverse event adenotonsillectomy. Conclusions In SDB, adenotonsillectomy, waiting, did not significantly improve However, had outcomes, including behavior, decreased pressure, follow-up. Trial Registration ClinicalTrials.gov Identifier: NCT02562040

Language: Английский

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Circadian rhythm regulates the function of immune cells and participates in the development of tumors

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 27, 2024

Abstract Circadian rhythms are present in almost all cells and play a crucial role regulating various biological processes. Maintaining stable circadian rhythm is essential for overall health. Disruption of this can alter the expression clock genes cancer-related genes, affect many metabolic pathways factors, thereby affecting function immune system contributing to occurrence progression tumors. This paper aims elucidate regulatory effects BMAL1, other on cells, reveal molecular mechanism rhythm’s involvement tumor its microenvironment regulation. A deeper understanding has potential provide new strategies treatment cancer immune-related diseases.

Language: Английский

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Relationship between accelerometer-measured sleep duration and Stroop performance: a functional near-infrared spectroscopy study among young adults

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17057 - e17057

Published: Feb. 28, 2024

Objectives Short sleep is becoming more common in modern society. This study aimed to explore the relationship between accelerometer-measured duration and cognitive performance among young adults as well underlying hemodynamic mechanisms. Methods A total of 58 participants were included this study. Participants asked wear an ActiGraph GT3X+ accelerometer identify their for 7 consecutive days. Cognitive function was assessed by Stroop test. Two conditions, including congruent incongruent Stroop, set. In addition, stratified analyses used examine sensitivity. 24-channel functional near-infrared spectroscopy (fNIRS) equipment applied measure changes prefrontal cortex (PFC) during tasks. Results showed that positively associated with accuracy test (0.001 (0.000, 0.002), p = 0.042). Compared regular (≥7 h) group, lower (−0.012 (−0.023, −0.002), 0.024) observed severe short (<6 h). Moreover, a analysis conducted examining gender, age, BMI, birthplace, education’s impact on accuracy, confirming consistent correlation across all demographics. activation left middle frontal gyri right dorsolateral superior negatively performance. Conclusions emphasized importance maintaining enough schedules college students from fNIRS perspective. The findings could potentially be guide time help them make schemes.

Language: Английский

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