Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in L-DOPA-Induced Dyskinesia DOI Open Access
Emanuela Santini, Emmanuel Valjent, Alessandro Usiello

et al.

Journal of Neuroscience, Journal Year: 2007, Volume and Issue: 27(26), P. 6995 - 7005

Published: June 27, 2007

The molecular basis of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID), one the major hindrances in current therapy for Parkinson9s disease, is still unclear. We show that attenuation cAMP signaling medium spiny neurons striatum, achieved by genetic inactivation dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32), reduces LID. also that, dyskinetic mice, sensitized cAMP/cAMP-dependent protein kinase/DARPP-32 leads to phosphorylation/activation extracellular signal-regulated kinases 1 2 (ERK1/2). increase ERK1/2 phosphorylation associated with results activation mitogen- stress-activated kinase-1 (MSK-1) histone H3, two downstream targets ERK involved transcriptional regulation. In line these observations, we found c-Fos expression abnormally elevated striata mice affected Persistent enhancement cascade implicated generation Thus, pharmacological using SL327 (α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile), an inhibitor mitogen-activated kinase/ERK kinase, MEK, during chronic l-DOPA treatment counteracts induction dyskinesia. Together, indicate a significant proportion abnormal involuntary movements developed response are attributable hyperactivation striatal pathway including sequential DARPP-32, ERK1/2, MSK-1, H3.

Language: Английский

Whole-brain activity mapping onto a zebrafish brain atlas DOI
Owen Randlett, Caroline Lei Wee, Eva A Naumann

et al.

Nature Methods, Journal Year: 2015, Volume and Issue: 12(11), P. 1039 - 1046

Published: Sept. 14, 2015

Language: Английский

Citations

456
Activity-Dependent Dendritic Arborization Mediated by CaM-Kinase I Activation and Enhanced CREB-Dependent Transcription of Wnt-2 DOI Creative Commons
Gary A. Wayman,

Soren Impey,

Daniel L. Marks

et al.

Neuron, Journal Year: 2006, Volume and Issue: 50(6), P. 897 - 909

Published: June 1, 2006

Language: Английский

Citations

455
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving DOI
Lin Lü, Bruce T. Hope,

Jack Dempsey

et al.

Nature Neuroscience, Journal Year: 2005, Volume and Issue: 8(2), P. 212 - 219

Published: Jan. 16, 2005

Language: Английский

Citations

445
Dynorphin, stress, and depression DOI

Allison T. Knoll,

William A. Carlezon

Brain Research, Journal Year: 2009, Volume and Issue: 1314, P. 56 - 73

Published: Sept. 25, 2009

Language: Английский

Citations

443
Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in L-DOPA-Induced Dyskinesia DOI Open Access
Emanuela Santini, Emmanuel Valjent, Alessandro Usiello

et al.

Journal of Neuroscience, Journal Year: 2007, Volume and Issue: 27(26), P. 6995 - 7005

Published: June 27, 2007

The molecular basis of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID), one the major hindrances in current therapy for Parkinson9s disease, is still unclear. We show that attenuation cAMP signaling medium spiny neurons striatum, achieved by genetic inactivation dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32), reduces LID. also that, dyskinetic mice, sensitized cAMP/cAMP-dependent protein kinase/DARPP-32 leads to phosphorylation/activation extracellular signal-regulated kinases 1 2 (ERK1/2). increase ERK1/2 phosphorylation associated with results activation mitogen- stress-activated kinase-1 (MSK-1) histone H3, two downstream targets ERK involved transcriptional regulation. In line these observations, we found c-Fos expression abnormally elevated striata mice affected Persistent enhancement cascade implicated generation Thus, pharmacological using SL327 (α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile), an inhibitor mitogen-activated kinase/ERK kinase, MEK, during chronic l-DOPA treatment counteracts induction dyskinesia. Together, indicate a significant proportion abnormal involuntary movements developed response are attributable hyperactivation striatal pathway including sequential DARPP-32, ERK1/2, MSK-1, H3.

Language: Английский

Citations

426