Immune attack: the role of inflammation in Alzheimer disease

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(6), P. 358 - 372

Published: May 20, 2015

Language: Английский

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Alzheimer Mechanisms and Therapeutic Strategies

Cell, Journal Year: 2012, Volume and Issue: 148(6), P. 1204 - 1222

Published: March 1, 2012

Language: Английский

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Lipid peroxidation in cell death

Biochemical and Biophysical Research Communications, Journal Year: 2017, Volume and Issue: 482(3), P. 419 - 425

Published: Jan. 1, 2017

Disruption of redox homeostasis is a key phenotype many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized mediators and inducers oxidative stress, increasingly, attention focused on the role lipid hydroperoxides critical death disease. As main component cellular membranes, lipids have an indispensible in maintaining structural integrity cells. Excessive oxidation alters physical properties membranes can cause covalent modification proteins nucleic acids. This review discusses synthesis, toxicity, degradation, detection peroxides biological systems. Additionally, peroxidation highlighted cell disease, strategies to control accumulation discussed.

Language: Английский

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An epigenetic blockade of cognitive functions in the neurodegenerating brain

Nature, Journal Year: 2012, Volume and Issue: 483(7388), P. 222 - 226

Published: Feb. 28, 2012

Language: Английский

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Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

Trends in Neurosciences, Journal Year: 2017, Volume and Issue: 40(3), P. 151 - 166

Published: Feb. 9, 2017

Language: Английский

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Bioinorganic Chemistry of Alzheimer’s Disease

Chemical Reviews, Journal Year: 2012, Volume and Issue: 112(10), P. 5193 - 5239

Published: July 13, 2012

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTBioinorganic Chemistry of Alzheimer's DiseaseKasper P. Kepp*View Author Information DTU Chemistry, Technical University Denmark, DK 2800 Kongens Lyngby, Denmark*E-mail: [email protected]Cite this: Chem. Rev. 2012, 112, 10, 5193–5239Publication Date (Web):July 13, 2012Publication History Received12 January 2012Published online13 July inissue 10 October 2012https://pubs.acs.org/doi/10.1021/cr300009xhttps://doi.org/10.1021/cr300009xreview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views14664Altmetric-Citations568LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF and HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ions,Metals,Oxidative stress,Peptides proteins,Zinc Get e-Alerts

Language: Английский

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Histone acetylation: molecular mnemonics on the chromatin

Nature reviews. Neuroscience, Journal Year: 2013, Volume and Issue: 14(2), P. 97 - 111

Published: Jan. 17, 2013

Language: Английский

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Neuroinflammation as a Common Feature of Neurodegenerative Disorders

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: Sept. 12, 2019

Neurodegenerative diseases share the fact that they derive from altered proteins undergo an unfolding process followed by formation of -structures, and a pathological tendency to self-aggregate in neuronal cells. This is characteristic tau protein Alzheimer´s disease several tauopathies associated unfolding, synuclein Parkinson huntingtin Huntington disease. Usually self-aggregation products are toxic these cells, toxicity spreads all over different brain areas. We have postulated events molecular alterations trigger neurodegenerative disorders. Most interestingly, occur as result neuroinflammatory cascades involving cross-talks between glial cells neurons consequence activation microglia astrocytes. The model we hypothesized for disease, involve damage signals promote activation, NFβ synthesis release proinflammatory cytokines such TNF-, IL1, IL-6, IL-12 affects receptors with overactivation kinases. These patterns can be applied In this context, involvement innate immunity seems major paradigm pathogenesis diseases. important element search potential therapeutic approaches

Language: Английский

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Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

British Journal of Pharmacology, Journal Year: 2012, Volume and Issue: 167(2), P. 324 - 352

Published: May 31, 2012

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying Alzheimer's disease (AD), although there presently lively debate regarding relative roles particular species/forms this peptide. Most recent evidence indicates that soluble oligomers rather than plaques are cause synaptic dysfunction and ultimately neurodegeneration. Soluble oligomeric Aβ has been shown interact with several proteins, for example glutamatergic receptors NMDA type proteins responsible maintaining glutamate homeostasis such as uptake release. As critically involved in neuronal plasticity including learning memory, we felt it would valuable provide an up date review connecting these related plasticity. Strong support clinical relevance interactions provided by receptor antagonist memantine. This substance only used clinically treatment AD therefore offers excellent tool facilitate translational extrapolations from vitro studies through vivo animal experiments its ultimate utility.

Language: Английский

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Current Developments of Coumarin Compounds in Medicinal Chemistry

Current Pharmaceutical Design, Journal Year: 2013, Volume and Issue: 19(21), P. 3884 - 3930

Published: April 1, 2013

Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This special structure enables its derivatives readily interact a diversity enzymes receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, some coumarin-based drugs such anticoagulant antineurodegenerative agents have been extensively used clinic. Coumarin-containing supramolecular new increasing expansion chemistry pharmaceutical science also actively investigated recent years. Coumarin-derived artificial ion receptors, fluorescent probes biological stains are growing quickly variety potential applications monitoring timely enzyme activity, complex events well accurate pharmacological pharmacokinetic properties. review provides systematic summary insight the whole range current developments coumarin anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory analgesic, antidiabetic, antidepressive other bioactive drugs, diagnostic pathologic probes, stains. Some rational design strategies, structure-activity relationships action mechanisms discussed. The perspectives future development coumarinbased presented. Keywords: Antibacterial, stain, coumarin, probe, drug.

Language: Английский

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