Keep off the grass? Cannabis, cognition and addiction

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(5), P. 293 - 306

Published: April 7, 2016

Language: Английский

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Inhibition in the amygdala anxiety circuitry

Experimental & Molecular Medicine, Journal Year: 2018, Volume and Issue: 50(4), P. 1 - 16

Published: April 1, 2018

Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the anxiolytic effect of benzodiazepine class γ-aminobutyric acid (GABA) receptor agonists and recent discovery anxiety-associated variants molecular components inhibitory synapses. Accordingly, substantial interest has focused on understanding how neurons synapses contribute to circuitry underlying adaptive pathological behaviors. A element is amygdala, which integrates information from cortical thalamic sensory inputs generate fear anxiety-related behavioral outputs. Information processing within amygdala heavily dependent control, although specific mechanisms GABAergic regulate behaviors are only beginning be uncovered. Here, we summarize current state knowledge highlight open questions regarding inhibition circuitry. We discuss neuron subtypes that basolateral central well determinants, such GABA receptors synapse organizer proteins, shape synaptic transmission Finally, conclude with an overview future approaches for converting this into successful treatment strategies disorders. Understanding developing more effective therapeutics against anxiety. Anxiety disorders most prevalent group psychiatric diseases, yet they often under-treated due limited efficacy tolerability approaches. Dilja Krueger-Burg colleagues at Max Planck Institute Experimental Medicine Göttingen, Germany, review neuronal circuits brain region emotions. It established alterations excessive excitatory underlie Using latest technologies identify populations implicated regulation should help develop new targeted treatments fewer side-effects.

Language: Английский

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Synaptic functions of endocannabinoid signaling in health and disease

Neuropharmacology, Journal Year: 2017, Volume and Issue: 124, P. 13 - 24

Published: June 16, 2017

Language: Английский

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Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

Neuropsychopharmacology, Journal Year: 2017, Volume and Issue: 43(1), P. 80 - 102

Published: July 26, 2017

Language: Английский

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Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(2), P. 337 - 349

Published: Jan. 8, 2019

Language: Английский

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Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

Progress in Lipid Research, Journal Year: 2022, Volume and Issue: 89, P. 101194 - 101194

Published: Sept. 20, 2022

N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N-docosahexaenoylethanolamine (DHEA, synaptamide) and their oxygenated metabolites are a lipid messenger family with numerous functions in health disease, inflammation, anxiety energy metabolism. The NAEs exert signaling role through activation of various G protein-coupled receptors (cannabinoid CB1 CB2 receptors, GPR55, GPR110, GPR119), ion channels (TRPV1) nuclear (PPAR-α PPAR-γ) the brain periphery. biological NAEs, such as prostamides, hydroxylated anandamide DHEA derivatives, less studied. Evidence is accumulating that oxidative may be aberrantly regulated or associated disease severity obesity, metabolic syndrome, cancer, neuroinflammation liver cirrhosis. Here, we comprehensively review NAE biosynthesis degradation, metabolism by lipoxygenases, cyclooxygenases cytochrome P450s these lipids. We discuss latest findings therapeutic potential modulating endogenous levels inhibition which currently under clinical evaluation for neuropsychiatric disorders. also highlight an emerging topic opportunities endocannabinoid signaling.

Language: Английский

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Fear of AI: an inquiry into the adoption of autonomous cars in spite of fear, and a theoretical framework for the study of artificial intelligence technology acceptance

AI & Society, Journal Year: 2023, Volume and Issue: 39(4), P. 1569 - 1584

Published: Jan. 22, 2023

Abstract Artificial intelligence (AI) is becoming part of the everyday. During this transition, people’s intention to use AI technologies still unclear and emotions such as fear are influencing it. In paper, we focus on autonomous cars first verify empirically extent which people then examine impact that has their AI-driven vehicles. Our research based a systematic survey it reveals while individuals largely afraid driven by AI, they nonetheless willing adopt technology soon possible. To explain tension, extend our analysis beyond just show also believe will generate many individual, urban global benefits. Subsequently, employ empirical findings foundations theoretical framework meant illustrate main factors ponder when consider tech. addition offering comprehensive for study acceptance, paper provides nuanced understanding tension exists between adoption capturing what exactly intend do.

Language: Английский

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Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Blood–brain barrier (BBB) alterations contribute to stress vulnerability and the development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unclear. Here we report that high expression astrocytic cannabinoid receptor 1 (CB1) in nucleus accumbens (NAc) shell, particularly end-feet ensheathing blood vessels, is associated with during chronic social adult male mice. Viral-mediated overexpression Cnr1 astrocytes NAc shell results baseline anxiolytic effects dampens stress-induced anxiety- depression-like behaviors It promotes vascular-related genes reduces astrocyte inflammatory response morphological changes following an immune challenge cytokine interleukin-6, linked susceptibility mood disorders. Physical exercise antidepressant treatment increase perivascular region human tissue from donors major disorder, observe loss CNR1 astrocytes. Our findings suggest a role for endocannabinoid system responses via modulation BBB. The mechanisms authors show modulates blood–brain

Language: Английский

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Overwriting an instinct: Visual cortex instructs learning to suppress fear responses

Science, Journal Year: 2025, Volume and Issue: 387(6734), P. 682 - 688

Published: Feb. 6, 2025

Fast instinctive responses to environmental stimuli can be crucial for survival but are not always optimal. Animals adapt their behavior and suppress reactions, the neural pathways mediating such ethologically relevant forms of learning remain unclear. We found that posterolateral higher visual areas (plHVAs) escapes from innate threats through a top-down pathway ventrolateral geniculate nucleus (vLGN). plHVAs no longer necessary after learning; instead, learned relies on plasticity within vLGN populations exert inhibitory control over escape responses. neurons receiving input enhance threat during endocannabinoid-mediated long-term suppression inputs. thus reveal detailed circuit, cellular, synaptic mechanisms underlying experience-dependent fear

Language: Английский

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Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies

Sleep Medicine Reviews, Journal Year: 2020, Volume and Issue: 53, P. 101339 - 101339

Published: May 16, 2020

Language: Английский

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