The transition to compulsion in addiction

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(5), P. 247 - 263

Published: March 30, 2020

Language: Английский

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Amygdala Circuit Substrates for Stress Adaptation and Adversity

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 89(9), P. 847 - 856

Published: Jan. 8, 2021

Brain systems that promote maintenance of homeostasis in the face stress have significant adaptive value. A growing body work across species demonstrates a critical role for amygdala promoting by regulating physiological and behavioral responses to stress. This review focuses on an emerging evidence has begun delineate contribution specific long-range circuits mediating effects After summarizing major anatomical features its connectivity other limbic structures, we discuss recent findings from rodents showing how causes structural functional remodeling neuronal outputs defined cortical subcortical target regions. We also consider some environmental genetic factors been found moderate responds relate preclinical literature current understanding pathophysiology treatment stress-related neuropsychiatric disorders. Future effort translate these clinics may help develop valuable tools prevention, diagnosis, diseases.

Language: Английский

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Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(6)

Published: Feb. 1, 2021

Significance Basal lateral amygdala and ventral CA1 are critical sites during chronic stress-induced depression. Here we demonstrated that AMPARs mediated weakening of pBLA-vCA1 innervation in mice subjected to CUMS. Stimulation via chemogenetics or administration cannabidiol (CBD) could reverse synaptosomal AMPAR decrease alleviate CUMS-induced depressive-like behaviors. These findings highlighted the importance an animal model depression revealed potential for CBD major treatment.

Language: Английский

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TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice

Neuron, Journal Year: 2024, Volume and Issue: 112(11), P. 1795 - 1814.e10

Published: March 21, 2024

Language: Английский

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Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 8, 2024

Abstract Compulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying not clearly defined. Here we show that basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to manifestation compulsive-like behaviors. We revealed BLA neurons projecting DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with neuronal population responds aversive predator stress, widely used anxiogenic stressor. Specific optogenetic BLA-DMS induced strong anxiety response followed by compulsive grooming. Furthermore, developed mouse model for compulsivity displaying wide spectrum chronically activating circuit. In these mice, persistent molecular changes at synapses were causally related phenotypes. Together, our study demonstrates involvement emergence enduring via its synaptic changes.

Language: Английский

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A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(3), P. 514 - 526

Published: Feb. 12, 2024

Language: Английский

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The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Language: Английский

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Endocannabinoid System Components as Potential Biomarkers in Psychiatry

Frontiers in Psychiatry, Journal Year: 2020, Volume and Issue: 11

Published: April 27, 2020

The high heterogeneity of psychiatric disorders, leads to a lack diagnostic precision. Therefore, the search biomarkers is fundamental aspect in psychiatry reach more personalized medicine. endocannabinoid system (ECS) has gained increasing interest due its involvement many different functional processes brain, including regulation emotions, motivation and cognition. This article reviews role main components ECS as certain disorders. Studies carried out rodents evaluating effects pharmacological genetic manipulation cannabinoid receptors or endocannabinoids (eCBs) degrading enzymes. Likewise, ECS-related alterations occurring at molecular level animal models reproducing some behavioral and/or neuropathological aspects disorders were reviewed. Clinical studies gene protein post-mortem brain tissue vivo blood, plasma cerebrospinal fluid (CSF) samples analyzed. Furthermore, results from neuroimaging using positron emission tomography (PET) magnetic resonance (fMRI) included. review shows close receptor 1 (CB1r) stress development mood (anxiety, depression, bipolar disorder (BD)), post-traumatic (PTSD), well etiopathogenesis schizophrenia, attention deficit hyperactivity (ADHD) eating (i.e. anorexia bulimia nervosa). On other hand, recent regarding potential therapeutic action tone by inhibition eCBs enzymes, modulation 2 (CB2r) activity on anxiolytic, antidepressive antipsychotic associated Further clinical research are needed, however, current evidence suggests that may become promising improve, least part, diagnosis treatment

Language: Английский

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The Gut Microbiome Regulates Psychological-Stress-Induced Inflammation

Immunity, Journal Year: 2020, Volume and Issue: 53(2), P. 417 - 428.e4

Published: July 30, 2020

Language: Английский

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An endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability

Journal of Clinical Investigation, Journal Year: 2019, Volume and Issue: 130(4), P. 1728 - 1742

Published: Dec. 24, 2019

Deficits in social interaction (SI) are a core symptom of autism spectrum disorders (ASDs); however, treatments for deficits notably lacking. Elucidating brain circuits and neuromodulatory signaling systems that regulate sociability could facilitate deeper understanding ASD pathophysiology reveal novel ASDs. Here we found vivo optogenetic activation the basolateral amygdala-nucleus accumbens (BLA-NAc) glutamatergic circuit reduced SI increased avoidance mice. Furthermore, 2-arachidonoylglycerol (2-AG) endocannabinoid BLA-NAc activity pharmacological 2-AG augmentation via administration JZL184, monoacylglycerol lipase inhibitor, blocked associated with stimulation. Additionally, inhibition markedly Shank3B-/- mouse, an model substantial impairment, without affecting WT Finally, demonstrated JZL184 delivered systemically or directly to NAc also normalized mice, while ex application corrected aberrant excitatory inhibitory neurotransmission BLA-NAc-elicited feed-forward neurons These data circuit-level mechanisms regulating function relevant ASDs suggest reduce modulation NAc.

Language: Английский

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