The Pathophysiology and the Management of Radiocontrast-Induced Nephropathy DOI Creative Commons
Eun‐Jung Cho, Gang-Jee Ko

Diagnostics, Journal Year: 2022, Volume and Issue: 12(1), P. 180 - 180

Published: Jan. 12, 2022

Contrast-induced nephropathy (CIN) is an impairment of renal function that occurs after the administration iodinated contrast medium (CM). Kidney dysfunction in CIN considered transient and reversible most cases. However, it third common cause hospital-acquired acute kidney injury associated with increased morbidity mortality, especially high-risk patients. Diagnostic interventional procedures require intravascular CM are being used increasing frequency, among elderly, who can be particularly susceptible to due multiple comorbidities. Therefore, identifying exact mechanisms its risk factors crucial not only provide optimal preventive management for at-risk patients, but also increase feasibility diagnostic procedure use CM. induces by impairing hemodynamics generation reactive oxygen species, addition direct cytotoxicity. Periprocedural hydration widely accepted strategy date. Here, we review latest research results on pathophysiology CIN.

Language: Английский

Renal functional reserve: from physiological phenomenon to clinical biomarker and beyond DOI Open Access

Alemayehu H. Jufar,

Yugeesh R. Lankadeva, Clive N. May

et al.

AJP Regulatory Integrative and Comparative Physiology, Journal Year: 2020, Volume and Issue: 319(6), P. R690 - R702

Published: Oct. 14, 2020

Glomerular filtration rate (GFR) is acutely increased following a high-protein meal or systemic infusion of amino acids. The mechanisms underlying this renal functional response remain to be fully elucidated. Nevertheless, they appear culminate in preglomerular vasodilation. Inhibition the tubuloglomerular feedback signal appears critical. However, nitric oxide, vasodilator prostaglandins, and glucagon also important. increase GFR during acid reveals “renal reserve,” which can utilized when physiological demand for single nephron increases. This has led concept that subclinical disease, before basal begins reduce, reserve recruited manner preserves function. extension once decline detected, disease already well progressed. likely applies both contexts chronic kidney acute injury. Critically, its corollary deficits have potential provide early detection dysfunction reduced. There growing evidence acids used identify patients at risk developing either injury as treatment target large multicenter clinical trials are required test these propositions. A renewed effort understand physiology warranted.

Language: Английский

Citations

83
Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways DOI Creative Commons
Huiling Xiang, Feng Zhu, Zhifeng Xu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: Feb. 27, 2020

Inflammasomes, multiprotein complex induced by harmful factors in the body, play a crucial role innate immunity. Activation of inflammasomes lead to activation casepase-1 and then secretion inflammatory cytokines, including IL-1β IL-18, subsequently leading type cell death called pyroptosis. There are two types signaling pathways involved process inflammasome activation: canonical non-canonical pathway. The pathway is mainly dependent on casepase-1; signal pathway, which was recently discovered, caspase-11, but also meditated caspase-4, caspase-5 caspase-8. Kidney inflammation basically associated with factor exudation infiltration. Several studies have showed that closely related kidney diseases, especially NLRP3 inflammasome, regulating fibrosis. In this review, we focus relationship between different kinds disease via both pathways.

Language: Английский

Citations

77
Long-Term Clinical Impact of Contrast-Associated Acute Kidney Injury Following PCI DOI Creative Commons
Reza Mohebi, Keyvan Karimi Galougahi,

Javier García

et al.

КАРДИОЛОГИЯ УЗБЕКИСТАНА, Journal Year: 2022, Volume and Issue: 15(7), P. 753 - 766

Published: March 16, 2022

Language: Английский

Citations

43
Dapagliflozin Attenuates Contrast-induced Acute Kidney Injury by Regulating the HIF-1α/HE4/NF-κB Pathway DOI Creative Commons
Xu Huang,

Xiaoxu Guo,

Gaoliang Yan

et al.

Journal of Cardiovascular Pharmacology, Journal Year: 2022, Volume and Issue: 79(6), P. 904 - 913

Published: March 31, 2022

Contrast-induced acute kidney injury (CI-AKI) causes clinically acquired nephropathy in patients who undergo coronary interventions. Hypoxic to proximal tubular epithelial cells is a pathological mechanism of CI-AKI. Previous studies have shown that hypoxia activates HIF-1α/HE4/NF-κB enhance renal fibrosis, and the SGLT-2 inhibitor luseogliflozin inhibits hypoxia-inducible factor (HIF)-1α expression reduce progression diabetic nephropathy. However, therapeutic effects mechanisms inhibitors on CI-AKI are unclear. We explored role pathway how dapagliflozin effectively treats by inhibiting this pathway. In vitro, were divided into control, hypoxia, + dapagliflozin, pSilencer-HIF-1α groups. Cellular apoptosis, related protein evaluated immunofluorescence, western blotting, flow cytometry, respectively. Dapagliflozin significantly decreased oxygen consumption, HIF-1α, human epididymis 4 (HE4), NF-κB expression, apoptotic compared with control (P < 0.01). vivo, rats (C), diabetes (D), contrast media, media Rats latter 2 groups treated for days. was induced intravenously injecting indomethacin, N-nitro-l-arginine methyl ester, iohexol. The elucidated assessing function, H&E staining, immunohistochemistry. Serum creatinine, urea nitrogen, TUNEL-positive cells, HE4, histopathological scores increased C, D, Thus, may ameliorate through suppression signaling vitro vivo.

Language: Английский

Citations

43
Renal-Clearable Probe with Water Solubility and Photostability for Biomarker-Activatable Detection of Acute Kidney Injuries via NIR-II Fluorescence and Optoacoustic Imaging DOI
Cheng Zeng,

Yunyan Tan,

Lihe Sun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 17664 - 17674

Published: April 3, 2023

Acute kidney injuries (AKI) have serious short-term or long-term complications with high morbidity and mortality rate, thus posing great health threats. Developing high-performance NIR-II probes for noninvasive in situ detection of AKI via fluorescent optoacoustic dual-mode imaging is significance. Yet chromophores often feature long conjugation hydrophobicity, which prevent them from being renal clearable, limiting their applications the diseases. To fully exploit advantageous features heptamethine cyanine dye, while overcoming its relatively poor photostability, to strive design a probe imaging, herein, we developed PEG3-HC-PB, water soluble, biomarker activatable has good photostability. As probe, fluorescence (900-1200 nm) quenched due existence electron-pulling phenylboronic group (responsive element), it exhibits weak absorption peak at 830 nm. Meanwhile, presence overexpressed H2O2 region case AKI, converted phenylhydroxy group, enhances emission (600-900 eventually produces conspicuous signals imaging. This enables contrast-agent-induced ischemia/reperfusion-induced mice using real-time 3D-MSOT response H2O2. Hence, this can be used as practicable tool detecting AKI; additionally, strategy could provide insight into other large-conjugation multifarious biological applications.

Language: Английский

Citations

36
microRNA-30c attenuates contrast-induced acute kidney injury by reducing renal tubular epithelial cell apoptosis via targeting SOCS1 DOI Creative Commons
Long Peng, Yanting Luo, Fang Tan

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: 446(2), P. 114456 - 114456

Published: Feb. 21, 2025

Language: Английский

Citations

1
Kidney Injury after Intravenous versus Intra-arterial Contrast Agent in Patients Suspected of Having Coronary Artery Disease: A Randomized Trial DOI Open Access

Eva Schönenberger,

Peter Martus, Maria Bosserdt

et al.

Radiology, Journal Year: 2019, Volume and Issue: 292(3), P. 664 - 672

Published: July 2, 2019

Background In the absence of randomized studies, it has been controversial whether likelihood acute kidney injury (AKI) differs between intravenous and intra-arterial contrast agent administration. Purpose To compare versus administration in relationship to AKI analyze association chronic disease (defined as at least mildly decreased estimated glomerular filtration rates [eGFRs]). Materials Methods This was a prospective study (ClinicalTrials.gov: NCT00844220) that involved randomizing participants with atypical chest pain suspected coronary artery (CAD) February 2009 August 2015 undergo CT angiography or cardiac catheterization prespecified secondary analysis compared (serum creatinine increase ≥ 25% 0.5 mg/dL after 18–24 46–50 hours) determined by blinded investigators using absolute differences relative risks, including two-sided 95% confidence intervals (CIs). Results A total 320 (163 [50.9%] women; mean age, 60 years ± 11) were included. Baseline eGFR did not differ group (84.3 mL/min/1.73 m2 17.2) (87.1 16.7) (P = .14). occurred nine 161 (5.6%; CI: 3%, 10%) 21 159 (13.2%; 9%,19%) (relative risk, 2.4; 1.1, 5.0; P .02). Also subgroup without obstructive CAD, those requiring interventions, more common (11.9%; 8%, 19%) than (4.3% [95% 2%, 9%]; difference, 7.7% 1.3%, 14.1%]; 2.8 7.0]; Obstructive CAD (odds ratio [OR]: 2.7 6.6]; .02), femoral catheter access (OR: 2.5 5.6]; .04), cine ventriculography associated 2.3 1.0, 4.9]; .03). multivariable analysis, presence postcontrast (hazard ratio: 12.4 4.5, 34.6]; < .01). Conclusion Acute this patients having disease. © RSNA, 2019 Online supplemental material is available for article. See also editorial Einstein Newhouse issue.

Language: Английский

Citations

67
Bioimpedance-Guided Hydration for the Prevention of Contrast-Induced Kidney Injury DOI Creative Commons
Mauro Maioli, Anna Toso,

Mario Leoncini

et al.

Journal of the American College of Cardiology, Journal Year: 2018, Volume and Issue: 71(25), P. 2880 - 2889

Published: June 1, 2018

Language: Английский

Citations

65
Role of Renal Hypoxia in the Progression From Acute Kidney Injury to Chronic Kidney Disease DOI
Md Mahbub Ullah, David P. Basile

Seminars in Nephrology, Journal Year: 2019, Volume and Issue: 39(6), P. 567 - 580

Published: Nov. 1, 2019

Language: Английский

Citations

63
Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via Beclin-1 pathway DOI Creative Commons
Tonghui Xu, Jialin Guo,

Maozeng Wei

et al.

JCI Insight, Journal Year: 2021, Volume and Issue: unknown

Published: July 6, 2021

The mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of acetaldehyde and endogenous lipid aldehydes. Approximately 40% East Asians, accounting for 8% human population, carry E504K mutation in ALDH2 that leads to accumulation toxic reactive aldehydes increases risk cardiovascular disease, cancer, Alzheimer among others. However, role acute kidney injury (AKI) remains poorly defined is therefore subject present study using various cellular organismal sources. In murine models, which AKI was induced by either contrast agent iohexol or renal ischemia/reperfusion, KO, activation/overexpression were associated with increased decreased injury, respectively. tubular epithelial cells (RTECs), upregulated Beclin-1 expression, promoted autophagy activation, eliminated ROS. vivo vitro, both 3-MA siRNAs inhibited abolished ALDH2-mediated renoprotection. mice iohexol-induced AKI, knockdown RTECs AAV-shRNA impaired activation aggravated injury. proximal HK-2 exposed iohexol, potentiated attenuated apoptosis. overexpression pretreatment regulated mitigating apoptosis summary, our data collectively substantiate a critical via involving pathway.

Language: Английский

Citations

42