A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

European Journal of Clinical Nutrition, Journal Year: 2019, Volume and Issue: 73(9), P. 1224 - 1235

Published: Jan. 15, 2019

Language: Английский

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PNPLA3 rs738409 is associated with renal glomerular and tubular injury in NAFLD patients with persistently normal ALT levels

Liver International, Journal Year: 2019, Volume and Issue: 40(1), P. 107 - 119

Published: Sept. 13, 2019

Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphism is associated with NAFLD severity and the PNPLA3 gene expressed in kidneys, but whether also renal tubular injury (RTI) uncertain. We assessed effect of genotypes on biomarkers RTI glomerular function subjects who had either normal (nALT) or abnormal (abnALT) alanine aminotransaminase levels.Two hundred seventeen patients histologically proven which 75 persistently nALT (below upper limit for months) were included. Multivariable regression analyses undertaken to test associations between genotype kidney dysfunction.The patient group higher urinary neutrophil gelatinase-associated lipocalin levels (u-NGAL, a biomarker RTI) (P < .001), albuminuria = .039) greater prevalence chronic disease (CKD; P .046) than abnALT group. The association GG risk CKD remained significant after adjustment factors histology, mostly Similarly, was u-NGAL group, even aforementioned filtration-based markers (β-coefficient: 22.29, 95% CI: 0.99-43.60, .041).Patients nALT, carry G allele, are at early damage. suggest genotyping may help identify RTI.

Language: Английский

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Obesity and chronic kidney disease: A current review

Obesity Science & Practice, Journal Year: 2022, Volume and Issue: 9(2), P. 61 - 74

Published: July 13, 2022

Abstract Background Obesity poses significant challenges to healthcare globally, particularly through its bi‐directional relationship with co‐morbid metabolic conditions such as type 2 diabetes and hypertension. There is also emerging evidence of an association between obesity chronic kidney disease (CKD) which less well characterized. Methods A literature search electronic libraries was conducted identify present a narrative review the interplay CKD. Findings may predispose CKD directly it linked histopathological finding obesity‐related glomerulopathy indirectly widely recognized complications atherosclerosis, hypertension, diabetes. The biochemical endocrine products adipose tissue contribute pathophysiological processes inflammation, oxidative stress, endothelial dysfunction, proteinuria. prevention management prove critical in counteracting both development advancement Moreover, measures abdominal adiposity waist circumference, are generally associated worse morbidity mortality individuals receiving maintenance hemodialysis. Conclusion risk factor for onset progression should be potential target preventative public health approach reduce rates within general population. Future research focus on use glucagon‐like peptide‐1 receptor agonists sodium–glucose cotransporter inhibitors patients due their multi‐faceted actions major outcomes.

Language: Английский

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Organ-organ communication: The liver's perspective

Theranostics, Journal Year: 2021, Volume and Issue: 11(7), P. 3317 - 3330

Published: Jan. 1, 2021

Communication between organs participates in most physiological and pathological events. Owing to the importance of precise coordination among liver virtually all body for maintenance homeostasis, many hepatic disorders originate from impaired organ-organ communication, resulting concomitant phenotypes distant organs. Hepatokines are proteins that predominantly secreted liver, hepatokines several signaling have been linked diseases other organs, such as heart, muscle, bone, eyes. Although liver-centered interorgan communication has proposed both basic clinical studies, date, regulatory mechanisms hepatokine production, secretion, reciprocation with factors obscure. Whether hormones cytokines involved also warrants investigation. Herein, we summarize current knowledge a variety possible involvement and/or important factors. This provides novel insight into underlying roles liver-originated signal transduction and, more importantly, understanding disease an integrative view.

Language: Английский

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Overweight, Obesity, and CVD Risk: a Focus on Visceral/Ectopic Fat

Current Atherosclerosis Reports, Journal Year: 2022, Volume and Issue: 24(4), P. 185 - 195

Published: March 2, 2022

Language: Английский

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