Body roundness index improves the predictive value of cardiovascular disease risk in hypertensive patients with obstructive sleep apnea: a cohort study

Clinical and Experimental Hypertension, Journal Year: 2023, Volume and Issue: 45(1)

Published: Oct. 8, 2023

Obesity, especially visceral obesity, plays an important role in the progression of cardiovascular disease (CVD). The body roundness index (BRI) is a new measure obesity that considered to reflect more comprehensively than other measures. This study aims evaluate relationship between BRI and CVD risk hypertensive patients with obstructive sleep apnea (OSA) explore its superiority predicting CVD.The Cox proportional hazards model was used calculate hazard ratios (HRs) 95% confidence intervals (CIs) for incident CVD. area under curve (AUC), continuous net reclassification improvement (NRI), integrated discrimination (IDI) were assess which measures had best predictive value risk.During median follow-up period 6.8 years, 324 participants suffered event. After multivariable adjustment, compared reference group (the first tertile), HRs (95% CI) 1.25 CI, 0.93-1.70) 1.74 1.30-2.33) subjects tertile 2 3 groups, respectively. Compared measurement indicators, has highest [AUC: 0.627, CI: 0.593-0.661]. addition fully adjusted multivariate improved power CVD, validated NRI IDI (all P < .05).BRI significantly associated OSA. Furthermore, may improve prediction

Language: Английский

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Association between Life’s Crucial 9 and overactive bladder: the mediating role of weight-adjusted-waist index

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Research suggests a potential connection between cardiovascular health, obesity, and overactive bladder (OAB). However, the mechanisms by which obesity influences relationship health OAB remain unclear. Life's Crucial 9 (LC9) is recently proposed method for assessing while weight-adjusted waist index (WWI) novel more accurate measure of obesity. This study investigates LC9 assesses whether WWI moderates this relationship. Data came from National Health Nutrition Examination Survey (NHANES). We used subgroup analyses, restricted cubic spline curves (RCS), multivariate logistic regression to explore OAB. Additionally, mediation analysis was conducted investigate association levels A total 25,319 participants were included in study, among 5,038 reported incidents After adjusting all variables using multivariable regression, an increase 10 units associated with 28% reduction incidence (OR = 0.72, 95% CI: 0.69, 0.76), one unit 40% 1.40, 1.29, 1.51). Consistent results also observed when categorized into quartiles, P trend <0.001. The splines indicated linear negative correlation LC9. Mediation revealed that 13.89% mediated (p 0.002). found significant OAB, acting as partial mediator provides new insights future research role mediator.

Language: Английский

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Waist to height ratio as a simple tool for predicting mortality: a systematic review and meta-analysis

International Journal of Obesity, Journal Year: 2023, Volume and Issue: 47(12), P. 1286 - 1301

Published: Sept. 28, 2023

Language: Английский

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Association between weight-adjusted waist index with incident stroke in the elderly with hypertension: a cohort study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 27, 2024

The objective of this study was to ascertain the relationship between weight-adjusted waist index (WWI) and risk stroke in an elderly hypertensive population, a that has not been previously elucidated. Cox regression model employed assess correlation baseline WWI measurements incidence stroke. To further elucidate shape association stroke, restricted cubic splines were employed. Furthermore, subgroup analyses interaction tests carried out investigate potential heterogeneities. Our cohort comprised 4962 individuals aged 60 years or older with no prior history Over median follow-up 3.2 years, we found 547 new-onset cases. After adjusting for confounding variables, analysis revealed positive hazard ratios (HRs) escalating progressively as values increased. When compared lowest quartile WWI, highest demonstrated HR 1.87 (95% CI, 1.44–2.42) Subgroup confirmed consistency across different demographic clinical strata. findings indicate elevated is significantly related higher among patients hypertension. These results underscore importance stratification tool. confirm these explore causal mechanisms behind observed correlation, more necessary.

Language: Английский

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Visceral adipose tissue is an independent predictor and mediator of the progression of coronary calcification: a prospective sub-analysis of the GEA study

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: April 3, 2023

Coronary artery calcium (CAC) improves cardiovascular event prediction. Visceral adipose tissue (VAT) is a cardiometabolic risk factor that may directly or through its related comorbidities determine the obesity-related risk. A clinical VAT estimator could allow an efficient evaluation of We aimed to analyze effect and factors on CAC progression.

Language: Английский

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Fatty Liver Index (FLI) Identifies Not Only Individuals with Liver Steatosis but Also at High Cardiometabolic Risk

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14651 - 14651

Published: Sept. 27, 2023

A fatty liver index (FLI) greater than sixty (FLI ≥ 60) is an established score for metabolic dysfunction-associated steatotic disease (MASLD), which carries a high risk diabetes and cardiovascular disease, while FLI ≤ 20 rules out the presence of steatosis. Thus, we investigated whether was associated with cardiometabolic factors, i.e., visceral (VAT), subcutaneous (SC), epicardial (EPI), extrapericardial (PERI), total cardiac (CARD-AT) adipose tissue, hepatic fat ((by magnetic resonance imaging, MRI, spectroscopy, MRS), insulin resistance (IR, HOMA-IR OGIS-index), components syndrome. All individuals 60 had MASLD, none steatosis (by MRS). Subjects higher BMI (VAT > 1.7 kg, CARD-AT 0.2 kg). positively increased FLI, VAT, were all IR, blood pressure, cholesterol, reduced HDL. For 60, cut-off values depots laboratory measures estimated. In conclusion, identified not only subjects but also those abdominal accumulation, hyperlipidemia, at diseases. Targeted reduction would help reduce risk.

Language: Английский

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Perirenal fat thickness contributes to the estimated 10-year risk of cardiovascular disease and atherosclerotic cardiovascular disease in type 2 diabetes mellitus

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 8, 2024

Objective Perirenal adipose tissue (PAT) has emerged as a potential therapeutic target for cardiovascular disease (CVD). However, the relationship between increased perirenal fat thickness (PrFT) and CVD risks in individuals with type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to evaluate association PrFT estimated 10-year risk of atherosclerotic (ASCVD) T2DM. Method The final analysis included 704 participants. was quantified using non-enhanced computed tomography scans, while ASCVD assessments were based on Framingham China-PAR equation scores, respectively. Multiple regression employed analyze correlation these scores. Results Higher quartiles displayed elevated scores ( P &lt;0.001). After adjusting cardiometabolic factors visceral area, remained significantly correlated men β =0.098, =0.036) women =0.099, =0.032). Similar correlations observed =0.106, =0.009) =0.108, =0.007). Moreover, an independent variable associated high ASCVD, odds ratios (ORs) 1.14 (95% CI: 1.04-1.25, =0.016) 1.20 1.11-1.31, &lt;0.001) risk, ORs 1.22 1.08-1.41, 1.34 1.12-1.60, risk. Furthermore, restricted cubic spline analyses confirmed nonlinear both genders nonlinearity overall &lt; 0.05). Conclusions contributed

Language: Английский

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Health Outcomes Associated with Olive Oil Intake: An Umbrella Review of Meta-Analyses

Foods, Journal Year: 2024, Volume and Issue: 13(16), P. 2619 - 2619

Published: Aug. 21, 2024

Several studies suggested a negative association between olive oil (OO) consumption and the risk of several chronic diseases. However, an attempt to systematically search, organize, evaluate existing evidence on all health outcomes associated with OO is lacking. The objective this review describe multiple consumption. Medline, Scopus, Web Science databases were searched through 5 April 2024. selected met following criteria: (1) meta-analysis both observational (case–control cohort studies) interventional (trials), (2) evaluation consumption, mortality, and/or incidence non-communicable/chronic degenerative diseases, (3) study population ≥18 years old. Two independent reviewers extracted relevant data assessed bias individual studies. PRISMA statement guidelines for Integration Evidence from Multiple Meta-Analyses followed. literature search identified 723 articles. After selection, 31 articles included in umbrella review. primary benefits observed cardiovascular diseases factors, cancer, diabetes, specific biomarkers related anthropometric status inflammation. As key component Mediterranean diet, can be considered healthy dietary choice improving positive outcomes.

Language: Английский

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Vitamin D and Visceral Obesity in Humans: What Should Clinicians Know?

Nutrients, Journal Year: 2022, Volume and Issue: 14(15), P. 3075 - 3075

Published: July 27, 2022

The extraskeletal effect of vitamin D on adipose tissue biology and modulation in human obesity is great interest has been extensively investigated. Current evidence from preclinical clinical studies suggests that the anti-inflammatory effects are evident consistent, whereas adipocyte differentiation, adipogenesis, energy metabolism supplementation adipokine levels inconclusive. Interventional related to medical surgical weight loss humans have shown small or no improvement status. Additionally, benefit for reduction visceral only demonstrated a few studies. Overall, findings relationship between still Further required confirm beneficial ameliorating dysfunction.

Language: Английский

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Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice

BMC Pharmacology and Toxicology, Journal Year: 2024, Volume and Issue: 25(1)

Published: March 19, 2024

Abstract Browning of white adipose tissue (WAT) is become an appealing target for therapeutics in the treatment obesity and related metabolic diseases. Dapagliflozin widely used type 2 diabetes, it also found that drug exhibits regulate systemic metabolism such as obesity, insulin resistance hepatic steatosis. However, precise role dapagliflozin on WAT remodeling remains to be elucidated. The current study aimed explore browning high-fat diet (HFD)-induced obese mice. Male C57BL/6J mice ( n = 6 per group) were establish model by following feeding with HFD weeks. randomly treated or without experimental observation. volume fat fraction quantified, H&E, UCP-1 staining immunohistochemistry conducted investigate white-to-brown conversion angiogenesis respectively. Quantitative real-time polymerase chain reaction (qPCR) was employed mRNA expression levels genes WAT. Subsequently, 3T3-L1 cells effect preadipocytes differentiation vitro. Our results demonstrated could reduce body weight gain promote induced via regulating lipogenesis Furthermore, differentiation, up-regulate adipocytes In conclusion, can potentially improving

Language: Английский

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