Molecular Cell, Journal Year: 2021, Volume and Issue: 81(18), P. 3708 - 3730
Published: Sept. 1, 2021
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 58(10), P. 2958 - 2978
Published: June 21, 2018
Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Bicontinuous phases consist of single bilayer that forms continuous periodic membrane lattice structure with pores two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, corona used for targeting they under physiological conditions. Compared liposomes, provides significantly higher surface area loading proteins small drug molecules. Owing recent advances, engineered in vitro both bulk nanoparticle formats applications including delivery, bioreactors, artificial cells, biosensors. This review outlines advances cubosome technology enabling their application guidelines rational design new systems biomedical applications.
Language: Английский
Citations
415
Journal of Clinical Investigation, Journal Year: 2019, Volume and Issue: 129(8), P. 3006 - 3017
Published: July 1, 2019
Development of novel and effective therapeutics for treating various cancers is probably the most congested challenging enterprise pharmaceutical companies. Diverse drugs targeting malignant nonmalignant cells receive clinical approval each year from FDA. Targeting cancer unavoidably changes tumor microenvironment, cellular molecular components relentlessly alter in response to drugs. Cancer often reprogram their metabolic pathways adapt environmental challenges facilitate survival, proliferation, metastasis. While cells' dependence on glycolysis energy production well studied, roles adipocytes lipid reprogramming supporting growth, metastasis, drug responses are less understood. This Review focuses emerging mechanisms involving metabolism altering treatment. In particular, we discuss underlying cancer-associated resistance.
Language: Английский
Citations
390
Cancer Cell, Journal Year: 2017, Volume and Issue: 32(6), P. 807 - 823.e12
Published: Dec. 1, 2017
Language: Английский
Citations
357
Trends in cancer, Journal Year: 2018, Volume and Issue: 4(5), P. 374 - 384
Published: April 6, 2018
Language: Английский
Citations
353
Cancer Letters, Journal Year: 2017, Volume and Issue: 401, P. 39 - 45
Published: May 17, 2017
Language: Английский
Citations
323
Journal of Bioenergetics and Biomembranes, Journal Year: 2020, Volume and Issue: 52(5), P. 321 - 342
Published: July 26, 2020
Abstract Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of most significant properties neoplastic cells is altered lipid metabolism, consequently, abnormal membrane composition. Like in case phosphatidylcholine, these changes result modulation certain enzymes accumulation energetic material, which could be used for a higher proliferation rate. The are so prominent, that some lipids, such as phosphatidylserines, even considered cancer biomarkers. Additionally, biophysical membranes lead resistance chemotherapy, finally disturbances signalling pathways. Namely, increased levels like instance phosphatidylserine, attenuation response. Also, saturation prevent from demanding conditions microenvironment. Particularly interesting significance cholesterol content metastasis. This review paper discusses roles each type physiology. combined theoretical data with clinical studies show novel therapeutic options concerning oncology.
Language: Английский
Citations
308
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12
Published: May 27, 2021
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ” composed of its own blood supply, lymphatic nervous systems, stroma, immune cells extracellular matrix (ECM). These components, utilizing both benign malignant cells, nurture the harsh, immunosuppressive nutrient-deficient environment necessary for cell growth, proliferation phenotypic flexibility variation. An important aspect TME cellular crosstalk cell-to-ECM communication. This interaction induces release soluble factors responsible evasion ECM remodeling, which further contribute to therapy resistance. Other aspects are presence exosomes contributed by circulating deregulated microRNAs TME-specific metabolic patterns potentiate progression and/or resistance therapy. In addition biochemical signaling, specific characteristics such as hypoxic environment, derangements, abnormal mechanical forces have been implicated in development treatment this review, we will provide an overview microenvironmental composition, structure, features that influence suppression
Language: Английский
Citations
308
Molecules, Journal Year: 2018, Volume and Issue: 23(8), P. 1941 - 1941
Published: Aug. 3, 2018
Cancer cells possess remarkable abilities to adapt adverse environmental conditions. Their survival during severe nutrient and oxidative stress depends on their capacity acquire extracellular lipids the plasticity of mechanisms for intracellular lipid synthesis, mobilisation, recycling. Lipid droplets, cytosolic fat storage organelles present in most from yeast men, are emerging as major regulators metabolism, trafficking, signalling various tissues exposed stress. biogenesis is induced by they accumulate cancers. droplets act switches that coordinate trafficking consumption different purposes cell, such energy production, protection against or membrane rapid cell growth. They sequester toxic lipids, fatty acids, cholesterol ceramides, thereby preventing lipotoxic damage engage a complex relationship with autophagy. Here, we focus stress-induced droplet biogenesis; roles nutrient, lipotoxic, stress; between The recently discovered principles biology can improve our understanding govern cancer adaptability resilience
Language: Английский
Citations
307
Molecules, Journal Year: 2020, Volume and Issue: 25(12), P. 2850 - 2850
Published: June 19, 2020
Antimicrobial peptides (AMPs), or host defense peptides, are small cationic amphipathic molecules produced by prokaryotic and eukaryotic organisms that play a key role in the innate immune against viruses, bacteria fungi. AMPs have either antimicrobial anticancer activities. Indeed, able to disrupt microbial cell membranes interacting with negatively charged phospholipids. Moreover, several capable trigger cytotoxicity of human cancer cells binding phosphatidylserine moieties which selectively exposed on outer surface plasma membranes. In addition, some AMPs, such as LTX-315, shown induce release tumor antigens potent damage associated molecular patterns causing alterations intracellular organelles cells. Given recognized medical need novel drugs, could represent potential source effective therapeutic agents, alone combination other molecules, oncology. this review we summarize describe properties mode action well strategies increase their selectivity toward specific
Language: Английский
Citations
304
British Journal of Cancer, Journal Year: 2019, Volume and Issue: 120(12), P. 1090 - 1098
Published: May 15, 2019
Cancer cells are often exposed to a metabolically challenging environment with scarce availability of oxygen and nutrients. This metabolic stress leads changes in the balance between endogenous synthesis exogenous uptake fatty acids, which needed by for membrane biogenesis, energy production protein modification. Alterations lipid metabolism and, consequently, composition have important therapeutic implications, as they affect survival, dynamics therapy response cancer cells. In this article, we provide an overview recent insights into regulation under discuss how adaptation helps thrive harsh tumour microenvironment.
Language: Английский
Citations
298