Dissemination of Enterococcal Genetic Lineages: A One Health Perspective DOI Creative Commons
João Narciso de Melo Marques,

Mariana Coelho,

Andressa Rodrigues Santana

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(7), P. 1140 - 1140

Published: July 1, 2023

Enterococcus spp. are commensals of the gastrointestinal tracts humans and animals colonize a variety niches such as water, soil, food. Over last three decades, enterococci have evolved opportunistic pathogens, being considered ESKAPE pathogens responsible for hospital-associated infections. Enterococci’s ubiquitous nature, excellent adaptative capacity, ability to acquire virulence resistance genes make them sentinel proxies assessing presence/spread pathogenic virulent clones hazardous determinants across settings human–animal–environment triad, allowing more comprehensive analysis One Health continuum. This review provides an overview enterococcal fitness traits; most common clonal complexes identified in clinical, veterinary, food, environmental sources; well dissemination genomic traits (virulome, resistome, mobilome) found high-risk worldwide,

Language: Английский

The plant microbiota signature of the Anthropocene as a challenge for microbiome research DOI Creative Commons
Gabriele Berg, Tomislav Cernava

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: March 26, 2022

Abstract Background One promise of the recently presented microbiome definition suggested that, in combination with unifying concepts and standards, research could be important for solving new challenges associated anthropogenic-driven changes various microbiota. With this commentary we want to further elaborate suggestion, because noticed specific signatures microbiota affected by Anthropocene. Results Here, discuss based on a review available literature our own targeting exemplarily plant microbiome. It is not only crucial plants themselves but also linked planetary health. We suggest that different human activities are commonly shift diversity evenness microbiota, which characterized decrease host specificity, an increase r-strategic microbes, pathogens, hypermutators. The resistome, anchored microbiome, follows antimicrobial resistance (AMR) mechanisms as well plasmid-associated genes. This typical signature Anthropocene often dysbiosis loss resilience, leads frequent pathogen outbreaks. Although several these observations already confirmed meta-studies, issue requires more attention upcoming studies. Conclusions Our aims inspire holistic studies development solutions restore save microbial ecosystem functioning closely connected

Language: Английский

Citations

59
Phage Products for Fighting Antimicrobial Resistance DOI Creative Commons

Yuanling Huang,

Wenhui Wang,

Zhihao Zhang

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1324 - 1324

Published: June 30, 2022

Antimicrobial resistance (AMR) has become a global public health issue and antibiotic agents have lagged behind the rise in bacterial resistance. We are searching for new method to combat AMR phages viruses that can effectively fight infections, which renewed interest as alternatives with their specificity. Large phage products been produced recent years AMR. Using “one health” approach, this review summarizes used plant, food, animal, human health. In addition, advantages disadvantages future perspectives development of therapy an alternative also discussed review.

Language: Английский

Citations

45
Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock DOI Creative Commons
Alexandre Maciel-Guerra, Michelle Baker, Yue Hu

et al.

The ISME Journal, Journal Year: 2022, Volume and Issue: 17(1), P. 21 - 35

Published: Sept. 23, 2022

Abstract A debate is currently ongoing as to whether intensive livestock farms may constitute reservoirs of clinically relevant antimicrobial resistance (AMR), thus posing a threat surrounding communities. Here, combining shotgun metagenome sequencing, machine learning (ML), and culture-based methods, we focused on poultry farm connected slaughterhouse in China, investigating the gut microbiome livestock, workers their households, microbial communities carcasses soil. For both resistomes this study, differences are observed across environments hosts. However, at finer scale, several similar genes (ARGs) associated mobile genetic elements were found human broiler chicken samples. Next, Escherichia coli, an important indicator for surveillance AMR farm. Strains E. coli intermixed between humans chickens. We that ARGs present faecal resistome showed correlation resistance/susceptibility profiles isolates cultured from same Finally, by using environmental sensing these be correlated variations temperature humidity. Our results show importance adopting multi-domain multi-scale approach when studying complex, interconnected environments.

Language: Английский

Citations

41
Understanding the intertwined nature of rising multiple risks in modern agriculture and food system DOI

Priti Khatri,

Prashant Kumar, Kaushlesh Singh Shakya

et al.

Environment Development and Sustainability, Journal Year: 2023, Volume and Issue: 26(9), P. 24107 - 24150

Published: Aug. 6, 2023

Language: Английский

Citations

38
Maternal-infant antibiotic resistance genes transference: what do we know? DOI Creative Commons
Anna Samarra, María Esteban-Torres, Raúl Cabrera‐Rubio

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 5, 2023

Resistance to antibiotics is becoming a worldwide threat as infections caused by multidrug-resistant pathogenic microorganisms can overcome antibiotic treatments and spread quickly in the population. In context of early life, newborns are at increased risk their immune system still under development, so acquisition resistance during childhood have short- long-term consequences for health. The moment birth first exposure infants possible antibiotic-resistant that may colonize gut other body sites. Different factors including mode delivery, previous mother, gestational age consumption early-life been described modulate neonate's microbiota, thus, resistome. Other factors, such lactation, also impact establishment development but little known about role breastmilk transferring Antibiotic Resistant Genes (ARG). A deeper understanding vertical transmission from mothers offspring necessary determine most effective strategies reducing life. this review, we aim present current perspective on resistances mother-infant dyads, well new insight study human resistome, public health problem, toward highlighting gaps knowledge need be closed.

Language: Английский

Citations

30
“One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis DOI Creative Commons
Tsepo Ramatla, Tshepo Mafokwane, Kgaugelo Edward Lekota

et al.

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 22, 2023

The Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bacterial isolates that produce extended-spectrum β-lactamases (ESBLs) contribute to global life-threatening infections. This study conducted a systematic review meta-analysis on the prevalence of ESBLs in co-existing E. K. isolated from humans, animals environment.The protocol was registered International Prospective Register Systematic Reviews (PROSPERO) [ID no: CRD42023394360]. carried out following preferred reporting items for reviews meta-analyses (PRISMA) guidelines. One hundred twenty-six eligible studies published antibiotic resistance between 1990 2022 were included.The pooled ESBL-producing 33.0% 32.7% 33.5% 19.4% animals, 56.9% 24.2% environment, 26.8% 6.7% animals/environment, respectively. Furthermore, three types genes encode ESBLs, namely blaSHVblaCTX-M,blaOXA, blaTEM, all detected concept "One-Health" surveillance is critical tracking source antimicrobial preventing its spread. emerging state national systems should include bacteria containing ESBLs. A well-planned, -implemented, -researched alternative treatment drug needs be formulated.

Language: Английский

Citations

30
Current Uses and Future Perspectives of Genomic Technologies in Clinical Microbiology DOI Creative Commons
Irene Bianconi,

Richard Aschbacher,

Elisabetta Pagani

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1580 - 1580

Published: Oct. 30, 2023

Recent advancements in sequencing technology and data analytics have led to a transformative era pathogen detection typing. These developments not only expedite the process, but also render it more cost-effective. Genomic analyses of infectious diseases are swiftly becoming standard for analysis control. Additionally, national surveillance systems can derive substantial benefits from genomic data, as they offer profound insights into epidemiology emergence antimicrobial-resistant strains. Antimicrobial resistance (AMR) is pressing global public health issue. While clinical laboratories traditionally relied on culture-based antimicrobial susceptibility testing, integration AMR holds immense promise. Genomic-based furnish swift, consistent, highly accurate predictions phenotypes specific strains or populations, all while contributing invaluable surveillance. Moreover, genome assumes pivotal role investigation hospital outbreaks. It aids identification infection sources, unveils genetic connections among isolates, informs strategies The One Health initiative, with its focus intricate interconnectedness humans, animals, environment, seeks develop comprehensive approaches disease surveillance, control, prevention. When integrated epidemiological systems, forecast expansion bacterial populations species transmissions. Consequently, this provides evolution relationships pathogens, hosts, environment.

Language: Английский

Citations

28
Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes DOI Creative Commons
Yuhao Fu,

Qingyuan Dou,

Kornelia Smalla

et al.

mLife, Journal Year: 2023, Volume and Issue: 2(4), P. 350 - 364

Published: Dec. 1, 2023

The emergence and rapid spread of antimicrobial resistance is global public health concern. gut microbiota harboring diverse commensal opportunistic bacteria that can acquire via horizontal vertical gene transfers considered an important reservoir sink antibiotic genes (ARGs). In this review, we describe the reservoirs ARGs their dynamics in both animals humans, use One Health perspective to track transmission ARG-containing between animals, environment, assess impact on human socioeconomic development. resistome evolve environment subject various selective pressures, including administration environmental lifestyle factors (e.g., diet, age, gender, living conditions), interventions through probiotics. Strategies reduce abundance clinically relevant antibiotic-resistant determinants niches are needed ensure mitigation acquired resistance. With help effective measures taken at national, local, personal, intestinal management, it will also result preventing or minimizing infectious diseases. This review aims improve our understanding correlations provide a basis for development management strategies mitigate crisis.

Language: Английский

Citations

23
Staphylococcus haemolyticus: An updated review on nosocomial infections, antimicrobial resistance, virulence, genetic traits, and strategies for combating this emerging opportunistic pathogen DOI
Ciro César Rossi, Faizan Ahmad, Marcia Giambiagi‐deMarval

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127652 - 127652

Published: Feb. 22, 2024

Language: Английский

Citations

15
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption DOI
Shakti K. Bhattarai, Muxue Du, Abigail L. Zeamer

et al.

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(730)

Published: Jan. 17, 2024

Despite their therapeutic benefits, antibiotics exert collateral damage on the microbiome and promote antimicrobial resistance. However, mechanisms governing recovery from are poorly understood. Treatment of Mycobacterium tuberculosis , world’s most common infection, represents longest exposure in humans. Here, we investigate gut dynamics over 20 months multidrug-resistant (TB) 6 drug-sensitive TB treatment We find that clearance shared predictive cofactors resolution TB-driven inflammation. The initial severe taxonomic functional disruption, pathobiont domination, enhancement antibiotic resistance initially accompanied long-term were countered by later commensals. This resilience was driven competing evolution mutations pathobionts commensals, with commensal strains reestablishing dominance. Fecal-microbiota transplantation antibiotic-resistant mice recapitulated to further disruption. These findings demonstrate commensals can have paradoxically beneficial effects promoting antimicrobials identify as a predictor disease therapy chronic infection.

Language: Английский

Citations

10