International Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
55(2)
Published: Dec. 18, 2024
Mental
stress
may
lead
to
ovarian
dysfunction.
Psychological
disrupts
function,
leading
adverse
in
vitro
fertilization
outcomes,
premature
insufficiency
and
decreased
reserve.
Furthermore,
psychological
caused
by
function
infertility
can
exacerbate
the
mental
burden.
In
animals,
leads
insufficiency,
resulting
in
irregular
estrous
cycles
The
present
study
summarizes
effects
of
psychogenic
on
underlying
mechanisms,
highlighting
involvement
hypothalamic‑pituitary‑adrenal,
sympathetic‑adrenal‑medullary
hypothalamic‑pituitary‑ovarian
axes,
as
well
neuroendocrine‑metabolic
network.
Moreover,
review
outlines
intervention
metabolic
strategies
for
improving
offering
potential
new
approaches
treating
hypofunction.
aims
clarify
understanding
stress‑induced
dysfunction
propose
alternative
infertility.
Cancers,
Journal Year:
2022,
Volume and Issue:
15(1), P. 110 - 110
Published: Dec. 24, 2022
The
pituitary
gland
is
one
of
the
most
cellularly
diverse
regions
brain.
Recent
advancements
in
transcriptomic
biology,
such
as
single-cell
RNA
sequencing,
bring
an
unprecedented
glimpse
into
molecular
composition
pituitary,
both
its
normal
physiological
state
and
disease.
Deciphering
signatures
provides
a
better
insight
ontological
origin
development
five
types
endocrine
cells,
process
involving
complex
cascades
transcription
factors
that
are
still
being
established.
In
parallel
with
these
observations
about
development,
recent
findings
on
neuroendocrine
tumors
(PitNETs)
demonstrate
preservations
changes
factor
expression
patterns
compared
to
those
seen
during
development.
Furthermore,
studies
also
identify
differentially
expressed
genes
drive
various
tumor
behaviors,
including
hormone
hypersecretion
aggression.
Understanding
comprehensive
multiomic
profiles
PitNETs
essential
developing
profile-based
therapies
for
not
curable
current
treatment
modalities
could
eventually
help
align
breakthroughs
made
applying
precision
medicine
other
tumors.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 5, 2023
Hedgehog
signaling
plays
pivotal
roles
in
embryonic
development,
adult
homeostasis
and
tumorigenesis.
However,
its
engagement
the
pituitary
gland
has
been
long
underestimated
although
embryogenic
development
are
closely
linked.
Thus,
deregulation
of
this
pathway
during
results
malformation
gland.
Research
last
years
further
implicates
a
regulatory
role
function
pituitary,
because
activity
is
also
interlinked
with
homeostasis,
hormone
production,
most
likely
formation
neoplasms
The
fact
that
can
be
efficiently
targeted
by
validated
therapeutic
strategies
makes
it
promising
candidate
for
treating
diseases.
We
here
summarize
current
knowledge
about
importance
review
recent
data
highlight
impact
healthy
diseased
Ruminants,
Journal Year:
2024,
Volume and Issue:
4(2), P. 182 - 191
Published: April 8, 2024
This
study
focused
on
exploring
the
metabolomic
profiles
of
crossbred
beef
cattle
with
varying
levels
residual
feed
intake
(RFI),
a
measure
efficiency
in
cattle.
Sixty-seven
growing
steers
(BW
=
277
±
29.7
kg)
were
subjected
to
high-forage
total
mixed
ration
for
64
days
determine
their
RFI
phenotypes.
At
end
64d
feeding
trial,
divided
into
two
groups
based
values:
low
(or
negative)-RFI
(n
28;
−1.08
0.88
kg/d)
and
high
positive)-RFI
39;
1.21
0.92
kg/d).
Blood
samples
collected,
plasma
analyzed
using
Nuclear
Magnetic
Resonance
spectroscopy,
resulting
identification
50
metabolites.
The
found
distinct
signature
associated
status.
Eight
metabolites,
including
amino
acids
(tyrosine,
glycine,
valine,
leucine,
methionine)
other
compounds
(dimethyl
sulfone,
3-hydroxy
isovaleric
acid,
citric
creatine,
L-carnitine),
showed
differential
abundance
between
low-
high-RFI
groups.
Specifically,
tyrosine,
dimethyl
sulfone
exhibited
significant
specificity
sensitivity,
which
produced
discriminatory
model
an
area
under
receiver
operating
characteristic
(ROC)
curve
0.7,
making
them
potential
markers
RFI.
A
logistic
regression
incorporating
these
biomarkers
effectively
distinguished
high-
low-RFI
steers,
threshold
cutoff
point
0.48,
highlighting
distinctive
metabolite
profile
efficient
nutrient
utilization
model,
biomarkers,
holds
promise
accurately
categorizing
values,
providing
insights
metabolic
basis
International Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
55(2)
Published: Dec. 18, 2024
Mental
stress
may
lead
to
ovarian
dysfunction.
Psychological
disrupts
function,
leading
adverse
in
vitro
fertilization
outcomes,
premature
insufficiency
and
decreased
reserve.
Furthermore,
psychological
caused
by
function
infertility
can
exacerbate
the
mental
burden.
In
animals,
leads
insufficiency,
resulting
in
irregular
estrous
cycles
The
present
study
summarizes
effects
of
psychogenic
on
underlying
mechanisms,
highlighting
involvement
hypothalamic‑pituitary‑adrenal,
sympathetic‑adrenal‑medullary
hypothalamic‑pituitary‑ovarian
axes,
as
well
neuroendocrine‑metabolic
network.
Moreover,
review
outlines
intervention
metabolic
strategies
for
improving
offering
potential
new
approaches
treating
hypofunction.
aims
clarify
understanding
stress‑induced
dysfunction
propose
alternative
infertility.
