Role of LncRNA MIAT in Diabetic Complications DOI
Lijun Wang, Hailin Wang, Yiyang Luo

et al.

Current Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 31(13), P. 1716 - 1725

Published: Sept. 15, 2023

Abstract: Long non-coding RNA (LncRNA) refers to a large class of RNAs with over 200 nucleotides that do not have the function encoding proteins. In recent years, more and literature has revealed lncRNA is involved in manipulating genes related human health disease, playing outstanding biological functions, which attracted widespread attention from researchers. The newly discovered long-stranded myocardial infarction-related transcript (LncRNA MIAT) abnormally expressed variety diseases, especially diabetic complications, been proven wide range effects. This review article aimed summarize importance LncRNA MIAT such as cardiomyopathy, nephropathy, retinopathy, highlight latest findings on pathway mechanism its participation regulating may aid finding new intervention targets for treatment complications. competitively binds microRNAs regulate gene expression competitive endogenous RNAs. Thus, this reviewed pathogenesis complications described role paper will help therapeutic strategies diabetes

Language: Английский

Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease DOI
Alla Mitrofanova, Sandra Merscher, Alessia Fornoni

et al.

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(10), P. 629 - 645

Published: July 27, 2023

Language: Английский

Citations

127

Steatotic liver disease, MASLD and risk of chronic kidney disease DOI Creative Commons
Josh Bilson, Alessandro Mantovani, Christopher D. Byrne

et al.

Diabetes & Metabolism, Journal Year: 2023, Volume and Issue: 50(1), P. 101506 - 101506

Published: Dec. 21, 2023

With the rising tide of fatty liver disease related to metabolic dysfunction worldwide, association this common with chronic kidney (CKD) has become increasingly evident. In 2020, more inclusive term dysfunction-associated (MAFLD) was proposed replace old nonalcoholic (NAFLD). 2023, a modified Delphi process led by three large pan-national associations. There consensus change nomenclature and definition include presence at least one five cardiometabolic risk factors as diagnostic criteria. The name chosen NAFLD steatotic (MASLD). from MAFLD then MASLD resulted in reappraisal epidemiological trends associations developing CKD. observed between MAFLD/MASLD CKD our understanding that can be an epiphenomenon linked underlying support notion individuals are substantially higher incident than those without MASLD. This narrative review provides overview literature on (a) evolution criteria for diagnosing highly prevalent disease, (b) evidence linking CKD, (c) mechanisms which (and strongly MASLD) may increase (d) potential drug treatments benefit both

Language: Английский

Citations

46

Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development DOI Creative Commons
Yu Yan, Hongbo Liu, Amin Abedini

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 29, 2024

Abstract Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic but are also preserved and transmitted during cell division. We conducted genome-wide cytosine methylation analysis 399 human samples, along with single-nuclear open chromatin on over 60,000 cells from 14 subjects, including controls, diabetes hypertension attributed chronic (CKD) patients. identified validated differentially methylated positions associated states, discovered that nearly 30% these alterations were influenced by underlying genetic variations, variants known to be association studies. regions showing both changes. These significantly gene expression changes, most notably those playing role metabolism expressed proximal tubules. Our study further demonstrated risk scores (MRS) can improve state annotation prediction development. Collectively, results suggest causal relationship between epigenetic pathogenesis, thereby providing potential pathways for the development novel stratification methods.

Language: Английский

Citations

15

Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2/HO-1 and FXR, and Suppressing ERK/VCAM-1 and NF-κB Pathways DOI
Hanan S. Althagafy, Emad H. M. Hassanein

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114092 - 114092

Published: Jan. 18, 2025

Language: Английский

Citations

2

Bile acid metabolism in health and ageing-related diseases DOI
Xiaojun Li,

Chu Fang,

Ruihua Zhao

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 225, P. 116313 - 116313

Published: May 22, 2024

Language: Английский

Citations

7

Novel targets for mucosal healing in inflammatory bowel disease therapy DOI

Pardis Mansouri,

Pegah Mansouri,

Esmaeil Behmard

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113544 - 113544

Published: Nov. 20, 2024

Language: Английский

Citations

7

Takeda G protein–coupled receptor 5 (TGR5): an attractive therapeutic target for aging-related cardiovascular diseases DOI Creative Commons

Yufeng He,

Si-qi Liu, Yali Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Aging is an independent risk factor for many chronic diseases, including cancer and cardiovascular, pulmonary, neurodegenerative diseases. In recent years, the mechanisms of aging-related cardiovascular diseases (CVDs) have been studied intensively. Takeda G protein-coupled receptor 5 (TGR5) a membrane bile acids that has found to play important role in various disease processes, such as inflammation, oxidative stress, metabolic disorders, all which contribute CVDs. this review, we summarise TGR5 CVDs propose attractive therapeutic target based on its mechanism involvement, may future drug design.

Language: Английский

Citations

1

Exploring the role and therapeutic potential of lipid metabolism in acute kidney injury DOI Creative Commons
Xiaoyu Zhang,

Wen Wu,

Yiming Li

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(2)

Published: Sept. 25, 2024

Acute kidney injury (AKI) is a prevalent condition, yet no specific treatment available. Extensive research has revealed the pivotal role of lipid-related alterations in AKI. Lipid metabolism plays an essential sustenance kidneys. In addition to their energy-supplying function, lipids contribute formation renal biomembranes and establishment microenvironment. Moreover, or metabolites actively participate signal transduction, which governs various vital biological processes, such as proliferation, differentiation, apoptosis, autophagy, epithelial-mesenchymal transition. While previous studies have focused predominantly on abnormalities lipid chronic disease, this review focuses anomalies We explore significance products potential biomarkers for early diagnosis classification Additionally, assesses current preclinical investigations modulation progression Finally, basis existing research, proposes future directions, highlights challenges, presents novel targets innovative ideas intervention

Language: Английский

Citations

4

Review on chronic metabolic diseases surrounding bile acids and gut microbiota: What we have explored so far DOI Creative Commons

Zhenzheng Zhu,

Yuemiao Xu,

Yuwei Xia

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122304 - 122304

Published: Nov. 26, 2023

Bile acid, the final product of cholesterol breakdown, functions as a complex regulator and signaling factor in human metabolism. Chronic metabolic diseases pose significant medical challenges. Growing research underscores bile acids' capacity to enhance metabolism via diverse pathways, regulating disorders offering treatment potential. Numerous bile-acid-triggered pathways have become targets. This review outlines acid synthesis, its role signal chronic diseases, highlights interaction with gut microbiota different conditions. Exploring host-bacteria-bile links emerges valuable future direction clinical implications.

Language: Английский

Citations

9

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Exploring Systemic Impacts and Innovative Therapies DOI
Parag Jain,

Akanksha Jain,

Rohitas Deshmukh

et al.

Clinics and Research in Hepatology and Gastroenterology, Journal Year: 2025, Volume and Issue: unknown, P. 102584 - 102584

Published: March 1, 2025

Language: Английский

Citations

0