Current Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
31(13), P. 1716 - 1725
Published: Sept. 15, 2023
Abstract:
Long
non-coding
RNA
(LncRNA)
refers
to
a
large
class
of
RNAs
with
over
200
nucleotides
that
do
not
have
the
function
encoding
proteins.
In
recent
years,
more
and
literature
has
revealed
lncRNA
is
involved
in
manipulating
genes
related
human
health
disease,
playing
outstanding
biological
functions,
which
attracted
widespread
attention
from
researchers.
The
newly
discovered
long-stranded
myocardial
infarction-related
transcript
(LncRNA
MIAT)
abnormally
expressed
variety
diseases,
especially
diabetic
complications,
been
proven
wide
range
effects.
This
review
article
aimed
summarize
importance
LncRNA
MIAT
such
as
cardiomyopathy,
nephropathy,
retinopathy,
highlight
latest
findings
on
pathway
mechanism
its
participation
regulating
may
aid
finding
new
intervention
targets
for
treatment
complications.
competitively
binds
microRNAs
regulate
gene
expression
competitive
endogenous
RNAs.
Thus,
this
reviewed
pathogenesis
complications
described
role
paper
will
help
therapeutic
strategies
diabetes
Diabetes & Metabolism,
Journal Year:
2023,
Volume and Issue:
50(1), P. 101506 - 101506
Published: Dec. 21, 2023
With
the
rising
tide
of
fatty
liver
disease
related
to
metabolic
dysfunction
worldwide,
association
this
common
with
chronic
kidney
(CKD)
has
become
increasingly
evident.
In
2020,
more
inclusive
term
dysfunction-associated
(MAFLD)
was
proposed
replace
old
nonalcoholic
(NAFLD).
2023,
a
modified
Delphi
process
led
by
three
large
pan-national
associations.
There
consensus
change
nomenclature
and
definition
include
presence
at
least
one
five
cardiometabolic
risk
factors
as
diagnostic
criteria.
The
name
chosen
NAFLD
steatotic
(MASLD).
from
MAFLD
then
MASLD
resulted
in
reappraisal
epidemiological
trends
associations
developing
CKD.
observed
between
MAFLD/MASLD
CKD
our
understanding
that
can
be
an
epiphenomenon
linked
underlying
support
notion
individuals
are
substantially
higher
incident
than
those
without
MASLD.
This
narrative
review
provides
overview
literature
on
(a)
evolution
criteria
for
diagnosing
highly
prevalent
disease,
(b)
evidence
linking
CKD,
(c)
mechanisms
which
(and
strongly
MASLD)
may
increase
(d)
potential
drug
treatments
benefit
both
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 29, 2024
Abstract
Epigenetic
changes
may
fill
a
critical
gap
in
our
understanding
of
kidney
disease
development,
as
they
not
only
reflect
metabolic
but
are
also
preserved
and
transmitted
during
cell
division.
We
conducted
genome-wide
cytosine
methylation
analysis
399
human
samples,
along
with
single-nuclear
open
chromatin
on
over
60,000
cells
from
14
subjects,
including
controls,
diabetes
hypertension
attributed
chronic
(CKD)
patients.
identified
validated
differentially
methylated
positions
associated
states,
discovered
that
nearly
30%
these
alterations
were
influenced
by
underlying
genetic
variations,
variants
known
to
be
association
studies.
regions
showing
both
changes.
These
significantly
gene
expression
changes,
most
notably
those
playing
role
metabolism
expressed
proximal
tubules.
Our
study
further
demonstrated
risk
scores
(MRS)
can
improve
state
annotation
prediction
development.
Collectively,
results
suggest
causal
relationship
between
epigenetic
pathogenesis,
thereby
providing
potential
pathways
for
the
development
novel
stratification
methods.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 20, 2025
Aging
is
an
independent
risk
factor
for
many
chronic
diseases,
including
cancer
and
cardiovascular,
pulmonary,
neurodegenerative
diseases.
In
recent
years,
the
mechanisms
of
aging-related
cardiovascular
diseases
(CVDs)
have
been
studied
intensively.
Takeda
G
protein-coupled
receptor
5
(TGR5)
a
membrane
bile
acids
that
has
found
to
play
important
role
in
various
disease
processes,
such
as
inflammation,
oxidative
stress,
metabolic
disorders,
all
which
contribute
CVDs.
this
review,
we
summarise
TGR5
CVDs
propose
attractive
therapeutic
target
based
on
its
mechanism
involvement,
may
future
drug
design.
Renal Failure,
Journal Year:
2024,
Volume and Issue:
46(2)
Published: Sept. 25, 2024
Acute
kidney
injury
(AKI)
is
a
prevalent
condition,
yet
no
specific
treatment
available.
Extensive
research
has
revealed
the
pivotal
role
of
lipid-related
alterations
in
AKI.
Lipid
metabolism
plays
an
essential
sustenance
kidneys.
In
addition
to
their
energy-supplying
function,
lipids
contribute
formation
renal
biomembranes
and
establishment
microenvironment.
Moreover,
or
metabolites
actively
participate
signal
transduction,
which
governs
various
vital
biological
processes,
such
as
proliferation,
differentiation,
apoptosis,
autophagy,
epithelial-mesenchymal
transition.
While
previous
studies
have
focused
predominantly
on
abnormalities
lipid
chronic
disease,
this
review
focuses
anomalies
We
explore
significance
products
potential
biomarkers
for
early
diagnosis
classification
Additionally,
assesses
current
preclinical
investigations
modulation
progression
Finally,
basis
existing
research,
proposes
future
directions,
highlights
challenges,
presents
novel
targets
innovative
ideas
intervention
Life Sciences,
Journal Year:
2023,
Volume and Issue:
336, P. 122304 - 122304
Published: Nov. 26, 2023
Bile
acid,
the
final
product
of
cholesterol
breakdown,
functions
as
a
complex
regulator
and
signaling
factor
in
human
metabolism.
Chronic
metabolic
diseases
pose
significant
medical
challenges.
Growing
research
underscores
bile
acids'
capacity
to
enhance
metabolism
via
diverse
pathways,
regulating
disorders
offering
treatment
potential.
Numerous
bile-acid-triggered
pathways
have
become
targets.
This
review
outlines
acid
synthesis,
its
role
signal
chronic
diseases,
highlights
interaction
with
gut
microbiota
different
conditions.
Exploring
host-bacteria-bile
links
emerges
valuable
future
direction
clinical
implications.
