Transgender Health,
Journal Year:
2020,
Volume and Issue:
5(4), P. 246 - 257
Published: June 9, 2020
Purpose:
Pubertal
suppression
is
standard
of
care
for
early
pubertal
transgender
youth
to
prevent
the
development
undesired
and
distressing
secondary
sex
characteristics
incongruent
with
gender
identity.
Preliminary
evidence
suggests
improves
mental
health
functioning.
Given
widespread
changes
in
brain
cognition
that
occur
during
puberty,
a
critical
question
whether
this
treatment
impacts
neurodevelopment.
Methods:
A
Delphi
consensus
procedure
engaged
24
international
experts
neurodevelopment,
development,
puberty/adolescence,
neuroendocrinology,
statistics/psychometrics
identify
priority
research
methodologies
address
empirical
question:
associated
real-world
neurocognitive
sequelae?
Recommended
study
approaches
reaching
80%
were
included
parameter.
Results:
The
identified
160
initial
expert
recommendations,
44
which
ultimately
achieved
consensus.
Consensus
design
elements
include
following:
minimum
three
measurement
time
points,
staging
at
baseline,
statistical
modeling
analyses,
use
analytic
account
heterogeneity,
multiple
comparison
groups
minimize
limitations
any
one
group.
untreated
matched
on
stage,
cisgender
(i.e.,
congruent)
an
independent
sample
from
large-scale
database.
domains
assessment
includes:
health,
executive
function/cognitive
control,
social
awareness/functioning.
Conclusion:
An
interdisciplinary
team
around
primary
methods
assessing
neurodevelopmental
effects
benefits
and/or
difficulties)
youth.
Cogent Business & Management,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: April 4, 2024
This
research
investigates
the
ethical
and
privacy
issues
arising
from
using
AI
andML
in
neuromarketing,
framed
by
rule
utilitarianism.
It
assesses
impact
of
these
technologies
on
consumerprivacy
human
rights
through
a
combination
literature
review,
bibliometric
analysis,
empirical
data
fromsurveys
interviews
with
experts
US
Spain.
The
study
reveals
tensions
between
efficacy
ofneuromarketing
techniques
imperative
to
protect
consumer
privacy,
particularly
light
GDPR'sinfluence
global
practices.
emphasizes
need
for
internationally
consistent
standards
consumerdata
regulations,
drawing
comparative
analysis
policies
EU.
outcomes
include
policyrecommendations
minimize
risks
promote
responsible
progression
neuromarketing.
Theserecommendations
guide
companies
managers
toward
transparency
accountability.
Additionally,
theresearch
offers
policy
framework
crafting
neuromarketing
practices
that
reconcile
technological
progresswith
well-being,
thereby
contributing
broader
discussions
embedding
ethics
within
innovation.
Reviews of Geophysics,
Journal Year:
2024,
Volume and Issue:
62(3)
Published: Aug. 13, 2024
Abstract
While
deterministically
predicting
the
time
and
location
of
earthquakes
remains
impossible,
earthquake
forecasting
models
can
provide
estimates
probabilities
occurring
within
some
region
over
time.
To
enable
informed
decision‐making
civil
protection,
governmental
agencies,
or
public,
Operational
Earthquake
Forecasting
(OEF)
systems
aim
to
authoritative
forecasts
based
on
current
activity
in
near‐real
Establishing
OEF
involves
several
nontrivial
choices.
This
review
captures
state
worldwide
analyzes
expert
recommendations
development,
testing,
communication
forecasts.
An
introductory
summary
OEF‐related
research
is
followed
by
a
description
Italy,
New
Zealand,
United
States.
Combined,
these
two
parts
an
informative
transparent
snapshot
today's
landscape.
In
Section
4,
we
analyze
results
elicitation
that
was
conducted
seek
guidance
for
establishment
systems.
The
identifies
consensus
dissent
issues
among
non‐representative
group
20
international
experts.
experts
agree
products
should
be
developed
collaboration
with
forecast
user
groups,
they
disagree
whether
testing
methods
user‐dependent.
No
strict
model
requirements
could
elicited,
but
benchmark
comparisons,
prospective
reproducibility,
transparency
are
encouraged.
5
gives
outlook
future
OEF.
Besides
covering
recent
development
upcoming
initiatives
described
context
findings.
PLoS Medicine,
Journal Year:
2024,
Volume and Issue:
21(5), P. e1004390 - e1004390
Published: May 6, 2024
When
research
evidence
is
limited,
inconsistent,
or
absent,
healthcare
decisions
and
policies
need
to
be
based
on
consensus
amongst
interested
stakeholders.
In
these
processes,
the
knowledge,
experience,
expertise
of
health
professionals,
researchers,
policymakers,
public
are
systematically
collected
synthesised
reach
agreed
clinical
recommendations
and/or
priorities.
However,
despite
influence
exercises,
methods
used
achieve
agreement
often
poorly
reported.
The
ACCORD
(ACcurate
COnsensus
Reporting
Document)
guideline
was
developed
help
report
any
in
biomedical
research,
regardless
field,
techniques
used,
application.
This
explanatory
document
facilitates
use
checklist.
Journal of Clinical Epidemiology,
Journal Year:
2024,
Volume and Issue:
174, P. 111485 - 111485
Published: July 26, 2024
Background
and
ObjectiveThe
minimum
sample
size
for
multistakeholder
Delphi
surveys
remains
understudied.
Drawing
from
three
large
international
surveys,
this
study
aimed
to:
1)
investigate
the
effect
of
increasing
on
replicability
results;
2)
assess
whether
level
results
differed
with
participant
characteristics:
example,
gender,
age,
profession.MethodsWe
used
data
to
develop
guidance
improved
reporting
health-care
intervention
trials:
SPIRIT
(Standard
Protocol
Items:
Recommendations
Interventional
Trials)
CONSORT
(Consolidated
Standards
Reporting
extension
surrogate
end
points
(n
=
175,
22
items
rated);
CONSORT-SPI
[CONSORT
Social
Psychological
Interventions]
333,
77
core
outcome
set
burn
care
553,
88
rated).
Resampling
replacement
was
draw
random
subsamples
in
each
surveys.
For
subsample,
median
value
all
rated
survey
calculated
compared
medians
full
set.
The
number
(and
interquartile
range)
replicated
calculate
percentage
variability).
High
defined
as
≥80%
moderate
60%
<80%ResultsThe
average
(variability)
a
total
datasets
81%
(10%)
at
60.
In
one
(CONSORT-SPI),
reached
80.
On
average,
80
160
increased
by
further
3%
reduced
variability
1%.
subgroup
analysis
based
characteristics
(eg,
professional
role),
using
resampled
samples
20
100
showed
that
30
resulted
levels
64%
77%.ConclusionWe
found
60–80
participants
provides
high
(≥80%)
results.
studies
limited
individual
stakeholder
groups
(such
researchers,
clinicians,
patients),
per
group
may
be
sufficient.
JMIR Aging,
Journal Year:
2025,
Volume and Issue:
8, P. e64352 - e64352
Published: March 5, 2025
The
number
of
centenarians
worldwide
is
expected
to
increase
dramatically,
reaching
3.4
million
by
2050
and
>25
2100.
Despite
these
projections,
depression
remains
a
prevalent
yet
underdiagnosed
undertreated
condition
among
this
population
that
carries
significant
health
risks.
This
study
aimed
identify
achieve
consensus
on
the
most
representative
signs
symptoms
in
near-centenarians
(aged
≥95
years)
through
an
e-Delphi
with
international
interdisciplinary
panel
experts.
Ultimately,
outcomes
might
help
create
screening
instrument
specifically
designed
for
unique
population.
A
modified
was
carried
out
expert
depressive
centenarians.
28
experts
recruited.
Consensus
defined
as
70%
agreement
relevance
each
item.
Data
were
collected
web-based
questionnaire
over
3
rounds.
Experts
rated
104
items
divided
into
24
dimensions
80
criteria
age
group.
consisted
from
various
countries,
including
physicians
experience
old
psychiatry
or
geriatrics
well
nurses
psychologists.
response
rate
remained
consistent
rounds
(20/28,
71%
21/28,
75%).
In
total,
4
new
8
proposed
experts,
reached
86%
(24/28)
80%
(70/88)
criteria.
consensual
potentially
relevant
lack
hope
(21/21,
100%),
loss
interest
(27/28,
96%),
reactivity
pleasant
events
depressed
mood
(26/28,
93%),
previous
episodes
diagnosed
(19/21,
90%).
addition,
despondency,
gloom,
despair
(25/25,
100%);
(27/27,
circumstances
(28/28,
suicidal
ideation
suicide
attempt(s)
ruminations
96%);
recurrent
thoughts
death
feelings
worthlessness
(25/26,
critical
life
(20/21,
95%);
anhedonia
activities
93%);
pleasure
sadness
(24/26,
92%).
Moreover,
when
assessing
very
age,
duration,
number,
frequency,
severity
should
also
be
considered,
evidenced
high
agreement.
classification
elements
highlights
importance
multidimensional
approach
optimal
individuals
age.
offers
first
step
toward
improving
assessment
development
more
adapted
tool
could
improve
early
detection
intervention,
enhancing
quality
mental
care
PLoS ONE,
Journal Year:
2021,
Volume and Issue:
16(8), P. e0256541 - e0256541
Published: Aug. 20, 2021
Digital
mobility
assessment
using
wearable
sensor
systems
has
the
potential
to
capture
walking
performance
in
a
patient’s
natural
environment.
It
enables
monitoring
of
health
status
and
disease
progression
evaluation
interventions
real-world
situations.
In
contrast
laboratory
settings,
occurs
non-conventional
environments
under
unconstrained
uncontrolled
conditions.
Despite
general
understanding,
there
is
lack
agreed
definitions
about
what
constitutes
walking,
impeding
comparison
interpretation
acquired
data
across
studies.
The
goal
this
study
was
obtain
expert-based
consensus
on
specific
aspects
provide
respective
common
terminological
framework.
An
adapted
Delphi
method
used
related
walking.
an
online
survey,
162
participants
from
panel
academic,
clinical
industrial
experts
with
experience
field
gait
analysis
were
asked
for
agreement
previously
specified
definitions.
Descriptive
statistics
evaluate
whether
consent
(>
75%
as
defined
priori)
reached.
Of
invited
participate,
51
completed
all
rounds
(31.5%
response
rate).
We
obtained
(“Walking”
>
90%,
“Purposeful”
75%,
“Real-world”
“Walking
bout”
80%,
speed”
“Turning”
90%
agreement)
after
two
rounds.
identification
consented
set
important
implications
development
protocols,
well
reporting
digital
outcomes
studies
systems.
will
serve
framework
implementing
mobile
technologies
are
link
transition
supervised
unsupervised
assessment.
BMC Public Health,
Journal Year:
2022,
Volume and Issue:
22(1)
Published: July 27, 2022
There
is
convincing
evidence
that
unhealthy
food
marketing
extensive
on
television
and
in
digital
media,
uses
powerful
persuasive
techniques,
impacts
dietary
choices
consumption,
particularly
children.
It
less
clear
whether
this
also
the
case
for
outdoor
marketing.
This
review
(i)
identifies
common
criteria
used
to
define
marketing,
(ii)
summarises
research
methodologies
used,
(iii)
available
exposure,
power
(i.e.
creative
strategies
within
marketing)
impact
of
behaviour
health
(iv)
knowledge
gaps
directions
future
research.
Environmental Challenges,
Journal Year:
2022,
Volume and Issue:
7, P. 100505 - 100505
Published: March 29, 2022
The
magnitude
of
environmental
challenges
we
are
facing
today
requires
the
involvement
a
diversity
stakeholders
and
collaborators
to
develop
socially,
culturally,
economically
robust
sustainability
practices.
Living
labs
catalyse
development
user-centric
solutions
for
complex
issues
by
exploring,
co-creating,
testing,
evaluating
innovations
within
real-world
contexts.
living
lab
approach
is
relatively
new
in
agricultural
sectors
but
quite
well
established
many
areas
such
as
information
communication
technology.
For
play
greater
role
sustainability,
present
research
agenda
related
evaluation
effectiveness
context
sustainability.
We
refer
act
assessing
process
outcomes
lab,
level
which
successful
achieving
certain
desirable
or
outcome.
Our
based
on
empirical
using
an
adapted
Delphi
method
–
iteratively
gather
input
from
panel
experts
involving
total
44
researchers
domains
labs,
methods,
agro-environmental
issues.
resulting
integrated
identifies
important
gaps
both
practice
improve
impact
labs.
findings
highlight
need
better
understand
effective
use
this
collaborative,
open
innovation
management
focused
Future
should
investigate
knowledge
have
identified
terms
stakeholders,
key
dimensions
how
enable
Journal of Personalized Medicine,
Journal Year:
2022,
Volume and Issue:
12(5), P. 846 - 846
Published: May 23, 2022
Chronic
rhinosinusitis
(CRS)
is
a
sino-nasal
chronic
inflammatory
disease,
occurring
in
5–15%
of
the
general
population.
CRS
with
nasal
polyps
(CRSwNP)
present
up
to
30%
One-third
CRSwNP
patients
suffer
from
disease
that
uncontrolled
by
current
standards
care.
Biologics
are
an
emerging
treatment
option
for
severe
CRSwNP,
but
their
positioning
algorithm
under
discussion.
Effective
endotyping
who
could
benefit
biologics
required,
as
suggested
international
guidelines.
Other
issues
affecting
management
include
comorbidities,
such
allergy,
non-steroidal
anti-inflammatory
drug–exacerbated
respiratory
and
asthma.
Therefore,
choice
depends
on
many
factors.
A
multidisciplinary
approach
may
improve
currently
there
no
shared
model.
We
summarize
outcomes
Delphi
process
involving
panel
otolaryngologists,
pulmonologists,
allergist-immunologists
involved
attempted
reach
consensus
key
statements
relating
diagnosis,
endotyping,
classification
(including
place
biologics)
patients.
JAMA Dermatology,
Journal Year:
2023,
Volume and Issue:
159(5), P. 545 - 545
Published: March 15, 2023
Therapy
for
advanced
melanoma
has
transformed
during
the
past
decade,
but
early
detection
and
prognostic
assessment
of
cutaneous
(CM)
remain
paramount
goals.
Best
practices
screening
use
pigmented
lesion
evaluation
tools
gene
expression
profile
(GEP)
testing
in
CM
to
be
defined.