Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(01), P. 407 - 414
Published: Jan. 1, 2025
Language: Английский
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(13), P. 7411 - 7422
Published: Feb. 23, 2024
Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively used a plasticizer to improve plasticity of agricultural products, which pose severe harm human health. Mitochondrial dynamics and endoplasmic reticulum (ER) homeostasis are indispensable for maintaining mitochondria-associated ER membrane (MAM) integrity. In this study, we aimed explore effect DEHP on nervous system its association with ER-mitochondria interaction. Here, showed that caused morphological changes, motor deficits, cognitive impairments, blood-brain barrier disruption in brain. triggered stress, is mainly mediated by protein kinase R-like (PERK) signaling. Moreover, DEHP-induced mitofusin-2 (Mfn2) downregulation results imbalance mitochondrial dynamics. Interestingly, exposure impaired MAMs inhibiting Mfn2-PERK Above all, study elucidates axis-mediated interaction phthalate-induced neurotoxicity could be potentially developed novel therapy neurological diseases.
Language: Английский
Citations
26
Atherosclerosis, Journal Year: 2025, Volume and Issue: unknown, P. 119113 - 119113
Published: Jan. 1, 2025
Language: Английский
Citations
2
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 1, 2024
Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% cases, may arise due to influence environmental factors. It was reported that periodontitis, common oral ailment, shares several risk factors with including advanced age, smoking, diabetes, and hypertension, among others. Periodontitis an inflammatory triggered dysbiosis microorganisms, whereas neuroinflammation. Many studies have indicated chronic inflammation can instigate brain AD-related pathologies, amyloid-β plaques, Tau protein hyperphosphorylation, neuroinflammation, neurodegeneration. The potential involvement periodontal pathogens and/or their virulence in onset progression AD oral-brain axis has garnered significant attention researchers ongoing investigations. This review updated potentially associated elucidating impact on central nervous system, immune response, related pathological processes provide valuable insights future research axis.
Language: Английский
Citations
10
Life, Journal Year: 2025, Volume and Issue: 15(1), P. 96 - 96
Published: Jan. 14, 2025
Recent research highlights compelling links between oral health, particularly periodontitis, and systemic diseases, including Alzheimer's disease (AD). Although the biological mechanisms underlying these associations remain unclear, role of periodontal pathogens, Porphyromonas gingivalis, has garnered significant attention. P. a major driver is recognized for its potential effects putative in AD pathogenesis. This review examines evidence connecting gingivalis to hallmark features, such as amyloid β accumulation, tau hyperphosphorylation, neuroinflammation, other neuropathological features consistent with AD. Virulence factors, gingipains lipopolysaccharides, were shown be implicated blood-brain barrier disruption, neuronal damage. gingivalis-derived outer membrane vesicles may serve disseminate virulence factors brain tissues. Indirect mechanisms, inflammation triggered by chronic infections, are also supposed exacerbate neurodegenerative processes. While exact pathways uncertain, studies detecting components AD-affected brains support their possible underscores need further investigation into gingivalis-mediated interplay host responses. Understanding interactions could provide critical insights novel strategies reducing risk through management.
Language: Английский
Citations
1
Molecular Therapy — Nucleic Acids, Journal Year: 2025, Volume and Issue: 36(1), P. 102480 - 102480
Published: Feb. 7, 2025
Overcoming the blood-brain barrier (BBB) remains a significant challenge for nucleic acid delivery to brain. We have explored combination of mannitol-modified poly (β-amino ester) (PBAE) nanoparticles and systemic mannitol injection crossing BBB. incorporated in PBAE polymer caveolae targeting selected monomers that may help avoid liver. also induced at BBB through order create an opportunity caveolae-targeting (M30 D90) containing plasmid DNA cross When clinically relevant dose was administered intravenously this induction model, M30 D90 demonstrated transgene expression reporter brain, with selective uptake by neuronal cells minimal liver accumulation. demonstrate modulation using administration designed are necessary efficient This platform offers simple, scalable, controlled solution holds promise treating brain diseases functional targets.
Language: Английский
Citations
1
Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(2)
Published: Feb. 1, 2025
ABSTRACT Background Alzheimer's disease (AD) is the most common chronic neurodegenerative disorder, with neuroinflammation playing an important role in its progression to become a major research focus. The of Porphyromonas gingivalis ( Pg ) and outer membrane vesicles OMVs) AD development uncertain, particularly regarding their effects on neuroinflammation. Methods cognition mice injected , OMVs, or PBS via tail vein was assessed by Morris water maze test. Pathological changes mouse brain were analyzed immunohistochemistry, immunofluorescence hematoxylin‒eosin (H&E) staining, ultrastructure hippocampus observed transmission electron microscopy (TEM). Plasma levels inflammatory factors enzyme‐linked immunosorbent assay (ELISA). Protein factor, occludin, NLRP3 inflammasome‐related proteins western blotting. Results Memory impairment; notable neuroinflammation, including astrocyte microglial activation; elevated protein IL‐1β, TNF‐α, IL‐6 detected OMV groups. However, induced weight loss systemic inflammation, such as splenomegaly increased IL‐1β TNF‐α plasma, whereas OMVs had minimal impact. In addition, more pronounced activation inflammasome compared OMVs. contrast, only group exhibited blood−brain barrier (BBB) disruption characterized reduced integrity tight junctions lower occludin protein. Conclusions associated significant immune response which turn exacerbates activating inflammasome. might elude disrupt junctions, thereby entering directly triggering
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 14, 2025
Porphyromonas gingivalis ( P. ) is a gram-negative bacterium and the main causative agent of periodontitis, disease closely associated with development periodontal disease. The progression chronic infectious disease, intricately linked to inflammatory immune response. Inflammatory cytokines act on tissues via immunomodulation, resulting in destruction tissue. Recent studies have established connections between periodontitis various systemic diseases, including cardiovascular tumors, neurodegenerative diseases. Neurodegenerative diseases are neurological disorders caused by system dysfunction, Alzheimer’s Parkinson’s One characteristics an impaired response, which mediates neuroinflammation through microglial activation. Some shown association as primary culprit. can cross blood-brain barrier (BBB) or mediate injury variety pathways, gut-brain axis, thereby affecting neuronal growth survival participating onset However, comprehensive systematic summaries origin lacking. This article reviews summarizes relationship its possible regulatory mechanisms. review offers new perspectives into understanding highlights innovative approaches for investigating developing tailored medications treating conditions, particularly from viewpoint their .
Language: Английский
Citations
1
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492
Published: Feb. 27, 2025
Language: Английский
Citations
1
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(1), P. 91 - 110
Published: Jan. 2, 2024
Using engineered exosomes produced from stem cells is an experimental therapeutic approach for treating brain diseases. According to reports, preclinical research has demonstrated notable neurogenesis and angiogenesis effects using modified cell-derived exosomes. These biological nanoparticles have a variety of anti-apoptotic, anti-inflammatory, antioxidant properties that make them very promising nervous system disorders.
Language: Английский
Citations
8
Mediators of Inflammation, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 8
Published: Feb. 20, 2024
Many attempts have been proposed to evaluate the linkage between oral–gut–liver axis and mechanisms related diseases’ establishment. One of them is oral microbiota translocation into bloodstream, liver, gut, promoting a host dysbiosis triggering presence some metabolites such as trimethylamine N-oxide (TMAO), known risk marker for cardiovascular disease, especially myocardial infarction (MI). In present pilot study, involvement TMAO has considered an independent component standard factors (SRs) in development MI, which not previously described human cohorts. A positive significant correlation levels with Porphyromonas was identified; likewise, increase genus Peptidiphaga patients without SRs observed. We determined that does influence concentration these patients. This report first study where relationship specified Mexican population. Our findings provide information on possible contribution pathogens associated gut although further analysis should be performed.
Language: Английский
Citations
7