Role of oral-gut-brain axis in psychiatric and neurological disorders DOI Open Access

Zhi-Min Duan,

Li‐Tzy Wu

Shijie huaren xiaohua zazhi, Journal Year: 2024, Volume and Issue: 32(12), P. 878 - 886

Published: Dec. 28, 2024

Language: Английский

Association between apical periodontitis and brain inflammation: a systematic review from animals and human studies DOI

Julia da Conceição Francisquini,

Luan Felipe Toro, Renato Gomes Azevedo

et al.

Odontology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
Unraveling the mechanisms underlying air pollution-induced dysfunction of the oral–gut–brain axis: implications for human health and well-being DOI
Sisi Chen, Wenlei Yu, Yiwen Shen

et al.

Asian Biomedicine, Journal Year: 2025, Volume and Issue: 19(1), P. 21 - 35

Published: Feb. 1, 2025

Air pollution exposure has become an international health issue that poses many risks to life and health. The bidirectional regulatory network, known as the oral-gut-brain axis connects oral cavity, intestine, central nervous system, well its influence on outcomes from air is receiving increased attention. This article systematically details epidemiological evidence linking pollutants diseases affecting oral, respiratory, intestinal, systems, while also explaining route of via axis. anomalies resulting their underlying molecular processes are covered. study provides a fresh viewpoint how affects investigates cutting-edge preventative therapeutic techniques.

Language: Английский

Citations

0
Gene Co-Expression Analysis Reveals Functional Differences Between Early- and Late-Onset Alzheimer’s Disease DOI Creative Commons

Abel Isaías Gutiérrez Cruz,

Guillermo de Anda‐Jáuregui, Enrique Hernández-Lemus

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 200 - 200

Published: March 18, 2025

The rising prevalence of Alzheimer’s disease (AD), particularly among older adults, has driven increased research into its underlying mechanisms and risk factors. Aging, genetic susceptibility, cardiovascular health are recognized contributors to AD, but how the age onset affects progression remains underexplored. This study investigates role early- versus late-onset (EOAD LOAD, respectively) in shaping trajectory cognitive decline. Leveraging data from Religious Orders Study Memory Aging Project (ROSMAP), two cohorts were established: individuals with early-onset AD those AD. Comprehensive analyses, including differential gene expression profiling, pathway enrichment, co-expression network construction, conducted identify distinct molecular signatures associated each cohort. Network modularity learning algorithms used discern inner structure networks their related functional features. Computed descriptors provided deeper insights influence at on biological

Language: Английский

Citations

0
The Oral–Gut Microbiome–Brain Axis in Cognition DOI Creative Commons

Noorul Ain Adil,

Christabel Omo-Erigbe,

Hariom Yadav

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 814 - 814

Published: April 3, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.

Language: Английский

Citations

0
Sialic acid metabolism of oral bacteria and its potential role in colorectal cancer and Alzheimer's disease DOI

Jiao Zhu,

Mengyang Li,

Jinfang Li

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 541, P. 109172 - 109172

Published: May 31, 2024

Language: Английский

Citations

1
Removable dentures and Alzheimer's disease DOI
E. Veseli

BDJ, Journal Year: 2024, Volume and Issue: 237(1), P. 11 - 11

Published: July 12, 2024

Language: Английский

Citations

1
Unraveling the cognitive implications among individuals with co-occurring chronic periodontitis and type 2 diabetes mellitus: a cross-sectional study DOI Creative Commons

Valliammai Rajendran,

Ashita Uppoor,

Sangeeta Umesh Nayak

et al.

Journal of Oral Biosciences, Journal Year: 2024, Volume and Issue: 66(3), P. 605 - 611

Published: May 28, 2024

Chronic periodontitis and type 2 diabetes mellitus (T2DM) are associated with cognitive decline when examined individually. To gain deeper insight into the combined effects of these conditions on decline, present study aimed to examine status individuals co-occurring T2DM chronic periodontitis.

Language: Английский

Citations

0
Role of oral-gut-brain axis in psychiatric and neurological disorders DOI Open Access

Zhi-Min Duan,

Li‐Tzy Wu

Shijie huaren xiaohua zazhi, Journal Year: 2024, Volume and Issue: 32(12), P. 878 - 886

Published: Dec. 28, 2024

Language: Английский

Citations

0