Obesity, metabolic syndrome, and primary hypertension

Pediatric Nephrology, Journal Year: 2020, Volume and Issue: 36(4), P. 825 - 837

Published: May 9, 2020

Primary hypertension is the dominant form of arterial in adolescents. Disturbed body composition with, among other things, increased visceral fat deposition, accelerated biological maturation, metabolic abnormalities typical for syndrome, and adrenergic drive constitutes intermediary phenotype primary hypertension. Metabolic syndrome observed 15-20% adolescents with These features are also obesity-related closely associated both severity risk target organ damage. However, even though mass index main determinant blood pressure general population, not every hypertensive adolescent obese patient suffers from or syndrome. Thus, concepts metabolically healthy obesity, normal weight unhealthy, unhealthy phenotypes have been developed. The damage increases exposure to factors which determined by disturbed obesity. Due fact that present similar pathogenesis, principles treatment same focused only on lowering pressure, but normalizing abnormalities.

Language: Английский

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A review of machine learning in hypertension detection and blood pressure estimation based on clinical and physiological data

Biomedical Signal Processing and Control, Journal Year: 2021, Volume and Issue: 68, P. 102813 - 102813

Published: June 1, 2021

The use of machine learning techniques in medicine has increased recent years due to a rise publicly available datasets. These have been applied high blood pressure studies following two approaches: hypertension stage classification based on clinical data and estimation related physiological signals. This paper presents literature review such studies. We aimed identify the best practices, challenges, opportunities developing models detect or estimate using Hence, we identified examined techniques, datasets, predictors used previous feature selection reduce model complexity are also reviewed. found lack combining socio-demographic with signals, despite correlation photoplethysmography waveforms variables as age, gender, body mass index, heart rate. Therefore, there is an opportunity increase performance by both types for detection monitoring.

Language: Английский

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Origins of Primary Hypertension in Children

Hypertension, Journal Year: 2020, Volume and Issue: 76(5), P. 1400 - 1409

Published: Sept. 28, 2020

Although relatively rare in childhood, primary hypertension (PH) is thought to have originated childhood and may be even determined perinatally. PH prevalence increases school-age children affects 11% of 18-year-old adolescents. Associated with metabolic risk factors, elevated blood pressure carried into adulthood. Analysis the phenotype hypertensive has revealed that a complex anthropometric neuro-immuno-metabolic abnormalities, typically found adults. Children shown signs accelerated biological development, which are closely associated further development PH, syndrome, cardiovascular disease At time diagnosis, were reported significant arterial remodelling expressed as significantly increased carotid intima-media thickness, stiffness large arteries, lower area microcirculation, decreased endothelial function. These changes indicate their age 4 5 years older than normotensive peers. All these abnormalities typical features early vascular aging described adults PH. However, observed subjects, it seems not only an event, but also maturation phenomenon.

Language: Английский

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Hemodynamic Patterns and Target Organ Damage in Adolescents With Ambulatory Prehypertension

Hypertension, Journal Year: 2019, Volume and Issue: 75(3), P. 826 - 834

Published: Dec. 30, 2019

Although the importance of office prehypertension/high normal blood pressure (BP) has been well documented, significance ambulatory prehypertension (AmbPreHT) not determined. We analyzed markers target organ damage and hemodynamics in adolescents with AmbPreHT comparison hypertensive normotensive subjects. Out 304 white patients aged 15.0±2.5 years hypertension, 30 children had were compared 66 healthy 92 true hypertension (elevated office, ambulatory, central BP), 22 (AmbHT), 70 severe AmbHT (SevAmbHT). Stroke volume cardiac output greater normotension but did differ between AmbPreHT, AmbHT, SevAmbHT. Similarly, SevAmbHT similar total peripheral resistance, lower than ( P <0.05). Central systolic BP was higher normotensives <0.01). In all 3 groups, carotid intima-media thickness Z scores significantly <0.001). left ventricular mass index prevalence hypertrophy Pulse wave velocity increased Multiple regression analysis showed that body score, BP, uric acid levels significant independent predictors index. conclusion, presented cardiovascular adaptations to those observed may be at risk developing events.

Language: Английский

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Elevated blood pressure, cardiometabolic risk and target organ damage in youth with overweight and obesity

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2020, Volume and Issue: 30(10), P. 1840 - 1847

Published: June 1, 2020

Language: Английский

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Increasing Trends in Obesity-Related Cardiovascular Risk Factors in Romanian Children and Adolescents—Retrospective Study

Healthcare, Journal Year: 2022, Volume and Issue: 10(12), P. 2452 - 2452

Published: Dec. 5, 2022

Childhood obesity has become a global public health issue and its assessment is essential, as an obese child future overweight or adult. Obesity no longer matter of exercising more eating less, with several factors coming into play dictating the pattern fat accumulation ease/difficulty reducing it. In current paper, we aimed to analyze cardiovascular impact in large number patients alongside paraclinical changes that occur due weight gain, perform analysis on increase prevalence throughout our research. The main conditions identified were hypertension (15.36%), septal concentric hypertrophic cardiomyopathy (11.15%), atherosclerosis risk (13.04%), hypercholesterolemia (20.94%). We have used echocardiography measure thickness epicardial adipose tissue (useful for assessing patient's risk), observed it was greater children moderate severe diastolic dysfunction left ventricle whole group, without any connection coronary impairment. Obese will be affected by increased mortality morbidity adulthood they may experience early dysfunction. want strongly underline importance necessity programs detection prevention complications, especially since interesting phenomena such "obesity paradox" exist prove far less understood than at first glance.

Language: Английский

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Body Mass Index is Associated with blood pressure and vital capacity in medical students

Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 18, 2023

Abstract Background The widely reported associations between body mass index (BMI) and various chronic diseases, such as hypertension asthma, have garnered significant attention. Nonetheless, there remains a dearth of research dedicated to understanding the health impacts medical school on students, who experience considerable academic pressure. In that context, this study was driven by goal investigating intricate interplay BMI, blood pressure (BP), vital capacity among students. Methods This included cohort 843 students enrolled at Southern Medical University were selected through random cluster sampling. Within cohort, measurements height, weight, BP, taken. Subsequently, both BMI (VCI) calculated for each participant. By categorizing subjects into four groups according classifications, comprehensive analysis correlation assessments binomial logistic regression conducted. Results participant pool, 9.4% 3.8% participants classified overweight obese, respectively. Additionally, prevalence prehypertension, hypertension, poor VCI 18.1%, 2.7%, 13.5%, Notably, male exhibited higher aforementioned issues than their female counterparts. Correlation revealed displayed positive with systolic (SBP), diastolic (DBP), (r = 0.372, 0.257, 0.428; P < 0.001). However, an inverse emerged -0.284, Further obese individuals faced elevated risk high ([OR 2.05, 95% CI 1.15–3.67] [OR 5.44, 2.28–13.02], respectively) compared normal-weight Moreover, these also 5.25, 3.04–9.06] 15.61, 6.81–35.81], respectively), while underweight experienced reduced 0.19, 0.07–0.52]). Conclusions demonstrated notably strong BP negative VCI. Therefore, well daily care patients, weight control is recommended better combat obesity-related example, cardiopulmonary gout diabetes.

Language: Английский

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Insulin Resistance in Pediatric Obesity: From Mechanisms to Treatment Strategies

Pediatric Diabetes, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Insulin resistance, an increasingly prevalent characteristic among children and adolescents with obesity, is now recognized as a significant contributor to the development of type 2 diabetes mellitus (T2DM) other metabolic diseases in individuals obesity. resistance refers decrease sensitivity peripheral tissues (primarily skeletal muscle, adipose tissue, liver) insulin, which mainly characterized by impaired glucose uptake utilization. Although mechanisms underlying insulin obesity remain incompletely elucidated, several risk factors including lipid metabolism disorders, oxidative stress (OS), mitochondrial dysfunction, inflammation, genetic have been identified pivotal contributors pathogenesis obesity‐related resistance. In this review, we comprehensively analyze relevant literature studies elucidate childhood Additionally, discuss treatment strategies for pediatric from perspective centered on improving sensitivity, aiming provide valuable insights prevention management

Language: Английский

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Association of a Healthy Lifestyle With Ambulatory 24-Hour Blood Pressure Among Chinese Youths: A Cross-Sectional Study

American Journal of Hypertension, Journal Year: 2024, Volume and Issue: 37(9), P. 674 - 681

Published: June 3, 2024

This study aims to explore the association between a healthy lifestyle and abnormal ambulatory blood pressure (ABP) in Chinese youths.

Language: Английский

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Association of heavy metals exposure with lower blood pressure in the population aged 8–17 years: a cross-sectional study based on NHANES

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: July 5, 2024

Background The existing evidence regarding the joint effect of heavy metals on blood pressure (BP) in children and adolescents is insufficient. Furthermore, impact factors such as body weight, fish consumption, age their association remains unclear. Methods study utilized original data from National Health Nutrition Examination Survey, encompassing 2,224 with complete information 12 urinary (barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, tungsten, uranium, mercury arsenic), BP, core covariates. Various statistical methods, including weighted multiple logistic regression, linear Weighted Quantile Sum regression (WQS), were employed to evaluate mixed metal exposure BP. Sensitivity analysis was conducted confirm primary analytical findings. Results findings revealed that low-level lead (0.40 μg/L, 95%CI: 0.37, 0.42), (0.38 0.35, 0.42) molybdenum (73.66 70.65, 76.66) exhibited reduced systolic (SBP) diastolic (DBP). Conversely, barium (2.39 2.25, 2.54) showed a positive increased SBP. A 25th percentile increase WQS index significantly associated decrease SBP 0.67 mmHg (95%CI, −1.24, −0.10) DBP 0.59 (95% CI, −1.06, −0.12), which statistically significant even after adjusting for weight. among individuals who consume fish, have more influence 25 3.30 −4.73, −1.87) SBP, primarily attributed (27.61%), cadmium (27.49%), cesium (17.98%), thallium (8.49%). also identified declining trend aged 10–17, whereas 11–18 lower levels pressure, along risk hypertension. Conclusion Some demonstrate an inverse BP adolescents, particularly notable groups consumption older adolescents. Future studies are warranted validate these delve deeper into interplay metals.

Language: Английский

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