Lipids in Health and Disease,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: July 12, 2023
Abstract
Background
In
light
of
the
high
prevalence
nonalcoholic
fatty
liver
disease
and
obesity,
treatment
options
for
steatohepatitis
are
particular
interest.
The
purpose
study
is
to
assess
efficacy
L-carnitine
its
effects
on
functional
state
liver,
as
well
lipid
carbohydrate
metabolism
in
patients
with
concomitant
obesity.
Methods
People
control
group
followed
a
hypocaloric
diet
received
1
tablet
simvastatin
20
mg
once
day
2
capsules
essential
phospholipids
600
three
times
90
days.
experimental
10
mL
orally
two
Results
normalized
blood
profile
subjects,
demonstrated
by
significant
decrease
levels
total
cholesterol,
triglycerides,
low-density
lipoproteins,
atherogenic
index,
insulin
resistance.
use
obesity
contributes
steady
reduction
main
clinical
biochemical
symptoms
steatohepatitis.
Conclusions
produces
positive
metabolism.
Chinese Medical Journal,
Journal Year:
2023,
Volume and Issue:
137(4), P. 457 - 464
Published: July 14, 2023
Abstract
Background:
Hypertension
and
non-alcoholic
fatty
liver
disease
(NAFLD)
share
several
pathophysiologic
risk
factors,
the
exact
relationship
between
two
remains
unclear.
Our
study
aims
to
provide
evidence
concerning
hypertension
NAFLD
by
analyzing
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2017–2018
Mendelian
randomization
(MR)
analyses.
Methods:
Weighted
multivariable-adjusted
logistic
regression
was
applied
assess
using
NHANES
2017–2018.
Subsequently,
a
two-sample
MR
performed
genome-wide
association
(GWAS)
summary
statistics
identify
causal
hypertension,
systolic
blood
pressure
(SBP),
diastolic
(DBP),
NAFLD.
The
primary
inverse
variance
weighted
(IVW)
other
supplementary
approaches
were
conducted
verify
Sensitivity
analyses
adopted
confirm
robustness
of
results.
Results:
A
total
3144
participants
enrolled
for
our
observational
in
NHANES.
analysis
suggested
that
positively
related
(odds
ratio
[OR]
=
1.677;
95%
confidence
interval
[CI],
1.159–2.423).
SBP
≥130
mmHg
DBP
≥80
also
significantly
correlated
with
Moreover,
independently
connected
steatosis
(
β
7.836
[95%
CI,
2.334–13.338]).
results
supported
(OR
7.203
2.297–22.587])
Similar
observed
exploration
1.024
1.003–1.046]),
1.047
1.005–1.090]),
sensitive
further
confirmed
reliability
these
findings
(all
P
>0.05).
Conclusion:
associated
an
increased
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(8), P. 2830 - 2830
Published: Aug. 18, 2021
Throughout
the
20th
and
21st
centuries,
incidence
of
non-communicable
diseases
(NCDs),
also
known
as
chronic
diseases,
has
been
increasing
worldwide.
Changes
in
dietary
physical
activity
patterns,
along
with
genetic
conditions,
are
main
factors
that
modulate
metabolism
individuals,
leading
to
development
NCDs.
Obesity,
diabetes,
metabolic
associated
fatty
liver
disease
(MAFLD),
cardiovascular
(CVDs)
classified
this
group
diseases.
Therefore,
understanding
underlying
molecular
mechanisms
these
leads
us
develop
more
accurate
effective
treatments
reduce
or
mitigate
their
prevalence
population.
Given
global
relevance
NCDs
ongoing
research
progress,
article
reviews
current
about
related
risk
factors,
a
focus
on
obesity,
MAFLD,
CVDs,
summarizing
knowledge
pathophysiology
highlighting
currently
available
emerging
therapeutic
strategies,
especially
pharmacological
interventions.
All
play
an
important
role
contamination
by
SARS-CoV-2
virus,
well
progression
severity
symptoms
coronavirus
2019
(COVID-19).
we
briefly
explore
relationship
between
COVID-19.
Food Science and Human Wellness,
Journal Year:
2022,
Volume and Issue:
12(4), P. 1174 - 1183
Published: Nov. 18, 2022
The
aim
of
this
study
was
to
explore
the
lipid-lowering
effect
naringenin
and
underlying
mechanism
in
high-fat-diet-fed
SD
rats
3T3-L1
cells.
In
study,
were
divided
into
normal
chow
diet
group
(NCD),
high
fat
(HFD),
three
treatment
groups
feeding
high-fat
with
(100,
200,
400
mg/kg)
for
12
weeks.
Results
indicated
that
decreased
total
cholesterol
(TC),
triglyceride
(TG)
non-high-density
lipoprotein
(non-HDL-C)
levels
serum.
Naringenin
also
alleviated
hepatic
steatosis
reduced
adipocyte
size
epididymis
high-fat-diet-induced
rats.
addition,
(25−75
µg/mL)
decrease
TG
TC
3T3
mature
adipocytes.
molecular
obesity
predicted
by
using
network
pharmacology.
Real-time
PCR
analysis
results
showed
regulated
expression
lipid
metabolism
genes.
Meanwhile,
increased
AMPK
(AMP-activated
protein
kinase)
activity
phosphorylated
And
inhibitory
on
accumulation
adipocytes
abolished
Compound
C.
Molecular
docking
could
bind
protein.
These
through
pathway.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: July 12, 2022
The
aim
of
this
study
was
to
investigate
the
effects
coix
seed-based
milk
(CSM)
fermented
with
Limosilactobacillus
reuteri
(
L.
)
on
dyslipidemia
and
composition
intestinal
microbiota
in
high
fat
diet
(HFD)-fed
mice.
Changes
body
weight,
serum
lipid
levels,
activities
hepatic
oxidative
stress
factors,
expression
lipid-related
genes,
HFD-fed
mice
after
supplementation
CSM
were
determined.
results
showed
that
intake
reduced
weight
gain
as
well
total
cholesterol
(TC),
triglyceride
(TG),
low-density
lipoprotein
(LDL-C)
increased
high-density
(HDL-C)
levels
Meanwhile,
could
relieve
liver
stress,
down-regulate
genes
related
synthesis,
prevent
accumulation
fed
HFD.
16S
rRNA
sequencing
regulated
gut
community
structure
at
different
taxonomic
reversed
dysbiosis
induced
by
relative
abundance
Muribaculaceae,
Lachnospiraceae,
Dubosiella
Akkermansia
which
are
negatively
correlated
blood
significantly
intervention
CSM,
while
Desulfovibrionaceae,
Ruminococca-ceae_UCG-014,
Psychrobacter
,
Staphylococcus
have
positive
correlation
decreased.
These
indicated
might
serve
a
novel
promising
dietary
supplement
for
ameliorating
hyperlipidemia
disorders
caused
HFDs.
