Nanophotonic-enhanced photoacoustic imaging for brain tumor detection DOI Creative Commons

Ali Rizwan,

Badrinathan Sridharan,

Jin Hyeong Park

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 5, 2025

Photoacoustic brain imaging (PABI) has emerged as a promising biomedical modality, combining high contrast of optical with deep tissue penetration ultrasound imaging. This review explores the application photoacoustic in tumor imaging, highlighting synergy between nanomaterials and state art techniques to achieve high-resolution deeper tissues. PABI leverages effect, where absorbed light energy causes thermoelastic expansion, generating waves that are detected converted into images. technique enables precise diagnosis, therapy monitoring, enhanced clinical screening, specifically management complex diseases such breast cancer, lymphatic disorder, neurological conditions. Despite integration agents radiation, providing comprehensive overview current methodologies, major obstacles treatment, future directions for improving diagnostic therapeutic outcomes. The underscores significance robust research tool medical method, potential revolutionize disease diagnosis treatment.

Language: Английский

Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges DOI
Wonseok Choi, Byullee Park, Seongwook Choi

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 7379 - 7419

Published: Jan. 16, 2023

For decades now, photoacoustic imaging (PAI) has been investigated to realize its potential as a niche biomedical modality. Despite highly desirable optical contrast and ultrasonic spatiotemporal resolution, PAI is challenged by such physical limitations low signal-to-noise ratio (SNR), diminished image due strong attenuation, lower-bound on spatial resolution in deep tissue. In addition, contrast-enhanced faced practical insufficient cell-specific targeting delivery efficiency difficulties developing clinically translatable agents. Identifying these essential the continuing expansion of field, substantial advances contrast-enhancing agents, complemented high-performance acquisition systems, have synergistically dealt with challenges conventional PAI. This review covers past four years research pushing terms SNR/contrast, targeted delivery, clinical application. Promising strategies for dealing each challenge are reviewed detail, future directions next generation discussed.

Language: Английский

Citations

122
Functional photoacoustic imaging: from nano- and micro- to macro-scale DOI Creative Commons
Byullee Park,

Donghyeon Oh,

Jeesu Kim

et al.

Nano Convergence, Journal Year: 2023, Volume and Issue: 10(1)

Published: June 19, 2023

Functional photoacoustic imaging is a promising biological technique that offers such unique benefits as scalable resolution and depth, well the ability to provide functional information. At nanoscale, has provided super-resolution images of surface light absorption characteristics materials single organelles in cells. microscopic macroscopic scales. techniques have precisely measured quantified various physiological parameters, oxygen saturation, vessel morphology, blood flow, metabolic rate oxygen, both human animal subjects. This comprehensive review provides an overview across multiple scales, from nano macro, highlights recent advances technology developments applications. Finally, surveys future prospects biomedical field.

Language: Английский

Citations

67
Oxygen imaging of hypoxic pockets in the mouse cerebral cortex DOI
Felix R. M. Beinlich, Antonis Asiminas, Verena Untiet

et al.

Science, Journal Year: 2024, Volume and Issue: 383(6690), P. 1471 - 1478

Published: March 28, 2024

Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain cannot store oxygen, and interruption oxidative phosphorylation fatal minutes. Yet only rudimentary knowledge exists regarding cortical partial oxygen tension (

Language: Английский

Citations

29
Simultaneous photoacoustic and ultrasound imaging: A review DOI

Yinshi Yu,

Ting Feng, Haixia Qiu

et al.

Ultrasonics, Journal Year: 2024, Volume and Issue: 139, P. 107277 - 107277

Published: Feb. 28, 2024

Language: Английский

Citations

25
A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption DOI Creative Commons
Hisham Assi, Rui Cao, Madhura Castelino

et al.

Photoacoustics, Journal Year: 2023, Volume and Issue: 32, P. 100539 - 100539

Published: Aug. 1, 2023

Photoacoustic imaging (PAI), also referred to as optoacoustic imaging, has shown promise in early-stage clinical trials a range of applications from inflammatory diseases cancer. While the first PAI systems have recently received regulatory approvals, successful adoption technology into healthcare for decision making must still overcome barriers, education and training data acquisition interpretation. The International Standardisation Consortium (IPASC) undertook an community exercise 2022 identify understand these then develop roadmap strategic plans address them. Here, we outline nature scope barriers that were identified, along with short-, medium- long-term efforts required them, both within beyond IPASC group.

Language: Английский

Citations

32
Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast DOI Creative Commons
Samuel John,

Scott C. Hester,

Maryam Basij

et al.

Photoacoustics, Journal Year: 2023, Volume and Issue: 32, P. 100533 - 100533

Published: July 17, 2023

In the past decade, photoacoustic (PA) imaging has attracted a great deal of popularity as an emergent diagnostic technology owing to its successful demonstration in both preclinical and clinical arenas by various academic industrial research groups. Such steady growth PA can mainly be attributed salient features, including being non-ionizing, cost-effective, easily deployable, having sufficient axial, lateral, temporal resolutions for resolving tissue characteristics assessing therapeutic efficacy. addition, integrated with ultrasound systems, combination which confers ability co-register cross-reference features structural, functional, molecular regimes. relies on either endogenous source contrast (e.g., hemoglobin) or those exogenous nature such nano-sized tunable optical absorbers dyes that may boost beyond provided sources. this review, we discuss applications they pertain clinically relevant niches, characterization, cancer diagnostics/therapies (termed theranostics), cardiovascular applications, surgical applications. We believe imaging's role facile indicator several disease-relevant states will continue expand evolve it is adopted increasing number laboratories clinics worldwide.

Language: Английский

Citations

28
Longitudinal intravital imaging of mouse placenta DOI Creative Commons
Xiaoyi Zhu, Qiang Huang, Laiming Jiang

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(12)

Published: March 20, 2024

Studying placental functions is crucial for understanding pregnancy complications. However, imaging placenta challenging due to its depth, volume, and motion distortions. In this study, we have developed an implantable window in mice that enables high-resolution photoacoustic fluorescence of development throughout the pregnancy. The exhibits excellent transparency light sound. By combining with ultrafast functional microscopy, were able investigate during entire mouse pregnancy, providing unprecedented spatiotemporal details. Consequently, examined acute responses alcohol consumption cardiac arrest, as well chronic abnormalities inflammation model. We also observed viral gene delivery at single-cell level chemical diffusion through by using imaging. Our results demonstrate intravital can be a powerful tool studying origins adverse outcomes.

Language: Английский

Citations

15
Ultrafast laser state active controlling based on anisotropic quasi-1D material DOI Creative Commons
Zixin Yang, Qiang Yu, Jian Wu

et al.

Light Science & Applications, Journal Year: 2024, Volume and Issue: 13(1)

Published: April 7, 2024

Laser state active controlling is challenging under the influence of inherent loss and other nonlinear effects in ultrafast systems. Seeking an extension degree freedom optical devices based on low-dimensional materials may be a way forward. Herein, anisotropic quasi-one-dimensional layered material Ta

Language: Английский

Citations

15
FPM-WSI: Fourier ptychographic whole slide imaging via feature-domain backdiffraction DOI Creative Commons
Shuhe Zhang,

Aiye Wang,

Jinghao Xu

et al.

Optica, Journal Year: 2024, Volume and Issue: 11(5), P. 634 - 634

Published: March 20, 2024

Fourier ptychographic microscopy (FPM) theoretically provides a solution to the trade-off between spatial resolution and field of view (FOV), has promising prospects in digital pathology. However, block reconstruction then stitching become an unavoidable procedure for large FOV due vignetting artifacts. This introduces artifacts, as existing image-domain optimization algorithms are highly sensitive systematic errors. Such obstacles significantly impede advancement practical implementation FPM, explaining why, despite decade development, FPM not gained widespread recognition biomedicine. We report feature-domain (FD-FPM) based on structure-aware forward model realize stitching-free, full-FOV reconstruction. The loss function is uniquely formulated feature domain images, which bypasses troublesome effect algorithmic vulnerability via backdiffraction. Through massive simulations experiments, we show that FD-FPM effectively eliminates artifacts reconstruction, still achieves impressive reconstructions presence various also found it great potential recovering data with lower spectrum overlapping rate, realizing refocusing without prior defocus distance. With FD-FPM, achieved full-color high-throughput imaging (4.7 mm diameter FOV, 336 nm blue channel) free blocking-and-stitching procedures self-developed whole slide platform. reported shows value experimental circumstances, offers physical insights useful developments models other computational techniques. platform demonstrates high-quality, high-speed low cost, could find applications many fields biomedical research, well clinical applications.

Language: Английский

Citations

12
Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope DOI Creative Commons

Xiaoxuan Zhong,

Yizhi Liang, Xiaoyu Wang

et al.

Light Science & Applications, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 2, 2024

Abstract We report the development of a head-mounted photoacoustic fiberscope for cerebral imaging in freely behaving mouse. The 4.5-gram probe has 9-µm lateral resolution and 0.2-Hz frame rate over 1.2-mm wide area. can continuously monitor oxygenation hemodynamic responses at single-vessel resolution, showing significantly different cerebrovascular to external stimuli under anesthesia moving state. For example, when subjected high-concentration CO 2 respiration, enhanced compensate hypercapnia be visualized due regulation Comparative studies exhibit weakened compensation capabilities obese rodents. This new modality used investigating both normal pathological functions shows great promise studying activity, disorders their treatments.

Language: Английский

Citations

10