Fam163a knockdown and mitochondrial stress in the arcuate nucleus of hypothalamus reduce AgRP neuron activity and differentially regulate mitochondrial dynamics in mice DOI Creative Commons
Cihan Süleyman Erdogan, Yavuz Yavuz,

Hüseyin Buğra Özgün

et al.

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(4)

Published: March 12, 2025

Abstract Aim Mitochondria play key roles in neuronal activity, particularly modulating agouti‐related protein (AgRP) and proopiomelanocortin (POMC) neurons the arcuate nucleus of hypothalamus (ARC), which regulates food intake. FAM163A, a newly identified protein, is suggested to be part mitochondrial proteome, though its functions remain largely unknown. This study aimed investigate effects Fam163a knockdown dysfunction on intake, AgRP neuron function hypothalamus. Methods Male C57BL/6 AgRP‐Cre mice received intracranial injections either shRNA, rotenone, or appropriate controls. Behavioral assessments included locomotor anxiety‐like behaviors. qRT‐PCR was used quantify expression genes related biogenesis, dynamics, oxidative stress. Blood glucose, serum insulin, leptin levels were measured. Electrophysiological patch‐clamp recordings assess activity. Results ARC increased cumulative intake short term (first 7 days) without altering 25‐day significantly Pomc mRNA expression. silencing reduced levels. Both rotenone firing frequency neurons. Neither nor altered differentially biogenesis‐, mitophagy‐, fusion‐, stress‐related genes. Conclusion Hypothalamic FAM163A may role activity through regulating redox state. These findings provide insights into stress central regulation metabolism.

Language: Английский

POMC neuronal heterogeneity in energy balance and beyond: an integrated view DOI
Carmelo Quarta, Marc Claret, Lori M. Zeltser

et al.

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(3), P. 299 - 308

Published: Feb. 25, 2021

Language: Английский

Citations

135
The hypothalamus for whole-body physiology: from metabolism to aging DOI Creative Commons
Tiemin Liu, Yong Xu, Chun‐Xia Yi

et al.

Protein & Cell, Journal Year: 2021, Volume and Issue: 13(6), P. 394 - 421

Published: April 7, 2021

Abstract Obesity and aging are two important epidemic factors for metabolic syndrome many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke cancers. The brain plays a central role in controlling physiology that it integrates information from organs, sends regulatory projections orchestrates the whole-body function. Emerging studies suggest dysfunction sensing various internal cues or processing external may have profound effects on physiological functions. This review highlights linked genetic mutations, sex, inflammation, microbiota, stress causes pathophysiology, arguing root cause of obesity-related disorders. We also speculate key issues need be addressed how reveal relevant underlines development these disorders order develop new treatment strategies against problems.

Language: Английский

Citations

79
Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity DOI Creative Commons
Xing Fang, Shujun Jiang, Jiangong Wang

et al.

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 26(6), P. 2299 - 2315

Published: Jan. 11, 2021

Abstract Previous studies have shown that AgRP neurons in the arcuate nucleus (ARC) respond to energy deficits and play a key role control of feeding behavior metabolism. Here, we demonstrate chronic unpredictable stress, an animal model depression, decreases spontaneous firing rates, increases irregularity alters properties both male female mice. These changes are associated with enhanced inhibitory synaptic transmission reduced intrinsic neuronal excitability. Chemogenetic inhibition susceptibility subthreshold stress. Conversely, chemogenetic activation completely reverses anhedonic despair behaviors induced by results indicate stress induces maladaptive plasticity, leading hypoactivity subsequently causing behavioral changes. Our findings suggest ARC component neural circuitry involved mediating depression-related increasing activity coule be novel effective treatment for depression.

Language: Английский

Citations

67
A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice DOI

Xing Cai,

Hailan Liu, Bing Feng

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(5), P. 646 - 658

Published: May 1, 2022

Language: Английский

Citations

39
Impact of insulin and insulin resistance on brain dopamine signalling and reward processing – An underexplored mechanism in the pathophysiology of depression? DOI
Judith Gruber, Ruth Hanßen, Mishal Qubad

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 149, P. 105179 - 105179

Published: April 12, 2023

Language: Английский

Citations

37
Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake DOI Creative Commons
Han L. Tan, Luping Yin, Yuqi Tan

et al.

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Leptin is an adipose tissue hormone that maintains homeostatic control of mass by regulating the activity specific neural populations controlling appetite and metabolism

Language: Английский

Citations

13
Mechanisms Involved in the Link between Depression, Antidepressant Treatment, and Associated Weight Change DOI Open Access

Tomas Kukucka,

Nikola Ferencová, Zuzana Višňovcová

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4511 - 4511

Published: April 20, 2024

Major depressive disorder is a severe mood associated with marked decrease in quality of life and social functioning, accompanied by risk suicidal behavior. Therefore, seeking out adhering to effective treatment great personal society-wide importance. Weight changes antidepressant therapy are often cited as the reason for withdrawal thus an important topic interest. There indeed exists significant mechanistic overlap between depression, treatment, regulation appetite body weight. The suggested pathomechanisms include abnormal functioning homeostatic (mostly humoral) hedonic dopaminergic) circuits regulation, well causing neuromorphological neurophysiological underlying development disorder. However, this issue still extensively discussed. This review aims summarize mechanisms linked depression context weight change.

Language: Английский

Citations

10
Neural circuits mediating chronic stress: Implications for major depressive disorder DOI
Hongling Guo, Tahir Ali, Shupeng Li

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111280 - 111280

Published: Feb. 3, 2025

Language: Английский

Citations

1
Promising Antidepressant Potential: The Role of Lactobacillus rhamnosus GG in Mental Health and Stress Response DOI Creative Commons
Musab Işık, Fadime Köse, Cansu Özbayer

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Chronic stress is linked to changes in brain physiology and functioning, affects the central nervous system (CNS), causes psychiatric diseases such as depression anxiety. In this study, antidepressant effects of probiotic bacterium Lactobacillus rhamnosus GG (ATCC 53103) (LGG) (15 × 10 8 cfu/ml/day) on mechanisms playing a role pathophysiology were investigated, results compared with bupropion (20 mg/kg/day) venlafaxine mg/kg/day). A total 56 male Wistar Albino rats used control, stress, bupropion, venlafaxine, LGG, + LGG groups, n = 7 each. Changes body weight during experiment determined by measurement. Gene expression levels RT-PCR method. Four different behavioral tests performed evaluate depressive behaviors (sucrose preference test, three-chamber sociability test (social interaction test), elevated plus maze forced swim test). treatment was effective reducing depressive-like behaviors, increased BDNF level, 5-HT1A, DRD1, ADRA-2A, GABA-A α1, CNR1 hippocampus NOD1 receptor level small intestine ( p < 0.05), also decreased neurodegeneration glial cell activity, intestinal permeability depressed rats. As result, it revealed study for first time that has properties found be more than drugs venlafaxine. Our suggest potential psychobiotic can useful treat depression. It may an option combating

Language: Английский

Citations

1
Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance DOI Creative Commons
Yanlin He, Pingwen Xu, Chunmei Wang

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: May 1, 2020

Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these are unclear. Here we report that estrogen receptor-α (ERα)-expressing in the ventrolateral subdivision ventromedial hypothalamic nucleus (vlVMH) can sense fluctuations, being glucose-inhibited (GI-ERα

Language: Английский

Citations

66