Anhedonia is associated with suicidal ideation independently of depression: A meta-analysis

Depression and Anxiety, Journal Year: 2017, Volume and Issue: 35(5), P. 382 - 392

Published: Dec. 12, 2017

Background Anhedonia is considered a suicide risk factor in patients with major affective disorders. Here, we wanted to quantify the association between anhedonia and current suicidal ideation according absence/presence of between-group differences for depressive scores psychiatric Methods We performed meta-analysis data on studies retrieved from Medline, Web Science, PsycINFO 1965 2016 using, among others, terms (suicid* or depression) anhedonia. Results identified 15 observational case–control that investigated individuals without (i.e., within past week, independently lifetime suicidality status) (defined as thoughts killing oneself). Overall, 657 subjects 6,690 could be compared. level was higher group than without, medium effect size (standardized mean difference = 0.57, z 5.43, P < 0.001, 95% confidence interval, CI 0.37–0.79). The remained significant when controlling depression scales used selected did not allow investigating consummatory motivational separately. Conclusion Our finding robust ideation, depression. This highly relevant clinicians' daily practice might help improving detection development new therapeutic strategies prevention.

Language: Английский

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ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: May 29, 2020

Abstract A key objective in the field of translational psychiatry over past few decades has been to identify brain correlates major depressive disorder (MDD). Identifying measurable indicators processes associated with MDD could facilitate detection individuals at risk, and development novel treatments, monitoring treatment effects, predicting who might benefit most from treatments that target specific mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies a lack reproducible findings have hindered progress. Here, we discuss work ENIGMA Major Depressive Disorder (MDD) Consortium, which was established address issues poor replication, unreliable results, overestimation effect sizes previous studies. The Consortium currently includes data 45 study cohorts 14 countries across six continents. primary aim is structural functional alterations can be reliably detected replicated worldwide. secondary goal investigate how demographic, genetic, clinical, psychological, environmental factors affect these associations. In review, summarize disease working group date future directions. We also highlight challenges benefits large-scale sharing for mental health research.

Language: Английский

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A Brain-Centric Model of Suicidal Behavior

American Journal of Psychiatry, Journal Year: 2020, Volume and Issue: 177(10), P. 902 - 916

Published: Oct. 1, 2020

Language: Английский

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Brain Structural and Functional Damage Network Localization of Suicide

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 95(12), P. 1091 - 1099

Published: Jan. 10, 2024

Language: Английский

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Individual-level risk factors for suicide mortality in the general population: an umbrella review

The Lancet Public Health, Journal Year: 2023, Volume and Issue: 8(11), P. e868 - e877

Published: Oct. 26, 2023

Deaths by suicide remain a major public health challenge worldwide. Identifying and targeting risk factors for mortality is potential approach to prevention. We aimed summarise current knowledge on the range magnitude of individual-level in general population evaluate quality evidence.

Language: Английский

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Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 89(2), P. 119 - 133

Published: June 10, 2020

Language: Английский

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The VLPFC versus the DLPFC in Downregulating Social Pain Using Reappraisal and Distraction Strategies

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 41(6), P. 1331 - 1339

Published: Dec. 21, 2020

The dorsolateral prefrontal cortex (DLPFC) and ventrolateral PFC (VLPFC) are both crucial structures involved in voluntary emotional regulation. However, it remains unclear whether the functions of these two cortical regions that regulation, which usually active non-social situations, could be generalized to regulation social pain as well. This study employed transcranial magnetic stimulation (TMS) examine causal relationship between DLPFC/VLPFC via distraction reappraisal. Ninety human participants (45 males 45 females) initially underwent either (DLPFC/VLPFC, n = 30/30) or sham (vertex, 30) TMS sessions. Participants were then instructed use reappraisal strategies downregulate any negative emotions evoked by exclusion pictures. Convergent results subjective rating electrophysiological indices demonstrated that: (1) DLPFC VLPFC highly facilitate downregulation affective responses caused exclusion, revealing a role lateral PFCs pain; (2) showed relative functional specificity for strategies, helps refine targeting therapeutic protocols. In addition, effect was sustainable at least 1 h, showcasing potential feasibility using this method clinical practice. Together, findings provide cognitive neural evidence and/or improve abilities, especially contexts. SIGNIFICANCE STATEMENT aimed particularly response through is relatively underexplored area inquiry. makes significant contribution literature because our novel empirical information on processing elicited within certain As such, have implications, paving way future clinicians able accurately target specific brain among patients struggling with impaired cognition including those diagnosed posttraumatic stress disorder, autism spectrum anxiety depression.

Language: Английский

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Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression

Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)

Published: Jan. 12, 2021

Abstract Suicidal ideation (SI) and non-suicidal self-injury (NSSI) are two distinct yet often co-occurring risk factors for suicide deaths in adolescents. Elucidating the neurobiological patterns that specifically characterize SI NSSI adolescents is needed to inform use of these markers intervention studies develop brain-based treatment targets. Here, we clinically assessed 70 adolescents—49 with depression 21 healthy controls—to determine history. Twenty-eight depressed had a history 29 (20 overlapping). All participants underwent resting-state fMRI scan. We compared groups network coherence subdivisions central executive (CEN), default mode (DMN), salience (SN). also examined group differences between-network connectivity explored brain-behavior correlations. Depressed lower ventral DMN those without or NSSI, respectively, controls (all p s < 0.043, uncorrected). anterior insula-SN 0.030, uncorrected), higher CEN–DMN ps Lower all subnetworks were associated past-month 0.001, Thus, our sample, both related brain networks difficulties self-referential processing future planning, while disruptions interoceptive awareness.

Language: Английский

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Prevalence, course, and determinants of suicide ideation and attempts in patients with a depressive and/or anxiety disorder: A review of NESDA findings

Journal of Affective Disorders, Journal Year: 2021, Volume and Issue: 283, P. 267 - 277

Published: Jan. 28, 2021

Depressive and anxiety disorders are often associated with suicide ideation (SI) attempt (SA). However, analyses of prevalence, course, more specific risk mechanisms needed to improve knowledge detection high individuals depressive disorders. Previous studies lacked statistical power, assessment detailed determinants follow-up measurements.The Netherlands Study Depression Anxiety (NESDA), a large cohort study, overcomes some earlier limitations. Scale for Suicide Ideation Compositive Interview Diagnostic Instrument data were analyzed report on prevalence SI SA. Additionally, important sociodemographic, clinical, psychological, environmental, neurobiological course SA identified in and/or disorder respondents 16 NESDA articles summarized.Within 12-month diagnosis (n=1,783), ranged from 17.1-20.1% 0.8-3.0% respectively across 5 waves during 9-year was highly recurrent. Both especially comorbid depression anxiety, higher clinical severity, sleep dysfunctions, aggression hopelessness, childhood trauma. In the (neuro)biological domain, linked immune dysregulation abnormal brain activity emotion processing genetic risk.Most cross-sectional nature, preventing causal inferences no conclusions could be drawn about overall magnitude results.SI multifactorial phenomena prevalent amongst respondents. Considering many overlapping determinants, use innovative methodological techniques desirable.

Language: Английский

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Neurobiological Basis of Increased Risk for Suicidal Behaviour

Cells, Journal Year: 2021, Volume and Issue: 10(10), P. 2519 - 2519

Published: Sept. 23, 2021

According to the World Health Organization (WHO), more than 700,000 people die per year due suicide. Suicide risk factors include a previous suicide attempt and psychiatric disorders. The highest mortality rate in worldwide is depression. Current evidence suggests that etiopathogenesis associated with neuroinflammation activates kynurenine pathway causes subsequent serotonin depletion stimulation of glutamate neurotransmission. These changes are accompanied by decreased BDNF (brain-derived neurotrophic factor) levels brain, which often linked impaired neuroplasticity cognitive deficits. Most suicidal patients have hyperactive hypothalamus-pituitary-adrenal (HPA) axis. Epigenetic mechanisms control above-mentioned neurobiological behaviour. could be attenuated appropriate psychological treatment, electroconvulsive drugs: lithium, ketamine, esketamine, clozapine. In this review, we present behaviour explore action anti-suicidal treatments, pinpointing similarities among them.

Language: Английский

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