Psychiatry Research, Journal Year: 2023, Volume and Issue: 326, P. 115314 - 115314
Published: June 22, 2023
Language: Английский
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(3), P. e241933 - e241933
Published: March 12, 2024
Adolescent major depressive disorder (MDD) is associated with serious adverse implications for brain development and higher rates of self-injury suicide, raising concerns about its neurobiological mechanisms in clinical neuroscience. However, most previous studies regarding the alterations adolescent MDD focused on single-modal images or analyzed different modalities separately, ignoring potential role aberrant interactions between structure function psychopathology.
Language: Английский
Citations
18
Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 130, P. 228 - 239
Published: Aug. 24, 2021
Nonsuicidal self-injury (NSSI) is a serious clinical problem, particularly for adolescents and young adults. NSSI complex behavior that emerges through the intersecting effects of social, psychological, biological mechanisms. Although social psychological contributions to risk developing are relatively well understood have guided development effective psychosocial treatments self-injury, mechanisms underlying just begun come light. To evaluate categorize research conducted on topic NSSI, we propose model distinguishes between trait state markers. According this model, factors involved in can be distinguished into both factors. We review existing evidence distal traits (predictors) proximal (correlates) states directly preceding or following NSSI. conclude by providing recommendations future neurobiology
Language: Английский
Citations
101
Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105394 - 105394
Published: Sept. 20, 2023
Youth depression has been associated with heterogenous patterns of aberrant brain connectivity. To make sense these divergent findings, we conducted a systematic review encompassing 19 resting-state fMRI seed-to-whole-brain studies (1400 participants, comprising 795 youths major and 605 matched healthy controls). We incorporated separate meta-analyses connectivity abnormalities across the levels most commonly seeded networks (default-mode limbic networks) and, based on recent additions to literature, an updated meta-analysis amygdala dysconnectivity in youth depression. Our findings indicated broad distributed at anatomical level, which could not be captured by conventional terms spatial convergence. However, were able parse complexity region-to-region considering constituent regions as components canonical networks. This integration revealed centred central executive, default mode, salience, networks, converging from adult literature suggesting similar neurobiological underpinnings
Language: Английский
Citations
22
General Psychiatry, Journal Year: 2023, Volume and Issue: 36(4), P. e100946 - e100946
Published: Aug. 1, 2023
Background Non-suicidal self-injury (NSSI) is a frequent and prominent phenomenon in major depressive disorder (MDD). Even though its prevalence risk factors are relatively well understood, the potential mechanisms of NSSI MDD remain elusive. Aims To review present evidence related to MDD. Methods According Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines, articles this systematic were searched on Medline (through PubMed), Embase Elsevier), PsycINFO OVID) Web Science databases English articles, as China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang Data, Chongqing VIP Chinese Technology Periodical (VIP) Databases published from date inception 2 August 2022. Two researchers (BW, HZ) independently screened studies based inclusion exclusion criteria assessed their quality. Results A total 25 157 searched. Only them ultimately included, containing 3336 subjects (1535 patients with NSSI, 1403 without 398 HCs). Included divided into 6 categories: psychosocial (11 studies), neuroimaging (8 stress hypothalamic-pituitary-adrenal (HPA) axis (2 pain perception (1 study), electroencephalogram (EEG) studies) epigenetics study). Conclusions This indicates that might have specific factors, aberrant brain functions neurochemical metabolisms, HPA dysfunctions, abnormal perceptions epigenetic alterations.
Language: Английский
Citations
18
NeuroImage, Journal Year: 2024, Volume and Issue: 292, P. 120589 - 120589
Published: April 1, 2024
Child maltreatment can adversely affect brain development, leading to vulnerabilities in structure and function various psychiatric disorders. Among the types of child maltreatment, neglect has highest incidence rate (76.0%); however, data on its sole adverse influence remain limited. This case-control magnetic resonance imaging (MRI) study identified changes gray matter that distinguish neglected children with no other type (Neglect group, n = 23) from typically developing (TD 140), investigated association between these structural functional differences specific psychosocial phenotypes observed children. Our results showed Neglect group had a larger right left anterior cingulate cortex (R/L.ACC) smaller angular gyrus (L.AG) volume. The R/L.ACC was associated hyperactivity inattention. Resting-state analysis increased connectivity (FC) supramarginal (L.SMG) salience network (SN) middle frontal (R.MFG) simultaneously decrease FC L.ACC for same seed. R.MFG difficulty peer problems depressive symptoms; mediating effect evident symptoms. These suggest atypicality indirectly contributes disturbed FCs within SN, thereby exacerbating symptoms In conclusion, exposure childhood may lead maladaptive particularly neural
Language: Английский
Citations
8
Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(3), P. 1046 - 1056
Published: Dec. 8, 2022
Language: Английский
Citations
27
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 350, P. 468 - 475
Published: Jan. 21, 2024
Language: Английский
Citations
5
Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 305, P. 8 - 18
Published: Feb. 15, 2022
Language: Английский
Citations
20
Environmental Sciences Europe, Journal Year: 2025, Volume and Issue: 37(1)
Published: Jan. 6, 2025
Lead is a prevalent heavy metal pollutant in the environment, and chronic lead exposure occupational settings has been linked to cognitive decline. Our objective was delineate lead-induced changes brain functional activity through assessment of regional homogeneity (ReHo), degree centrality (DC) seed-based connectivity (FC) using resting-state magnetic resonance imaging (rs-fMRI). In this cross-sectional study, we recruited 76 participants from smelting company. Based on their blood levels, 26 were assigned group (≥ 300 μg/L), whereas 23 control (≤ 100 μg/L). Neuropsychological assessments included Montreal Cognitive Assessment, Mini-Mental State Examination, Self-rating Anxiety Scale, Depression Scale. Participants underwent rs-fMRI for ReHo, DC, FC analyses. Brain regions demonstrating significant differences ReHo DC identified as interest subsequent analysis. We also examined relationships between values, neuropsychological scores. Compared group, individuals with high exhibited increased bilateral insula vermis elevated left olfactory cortex. Notably, demonstrated reduced right cerebellar crus I, fusiform gyrus, superior frontal middle gyrus. The displayed gyrus but cortex insula. Furthermore, negative correlations observed levels (r = − 0.586), 0.556), 0.626), well 0.587). Conversely, there positive association 0.609), an inverse relationship noted neurocognitive assessments. disruption coordination may significantly impair long-range contribute deficits resulting exposure. appears be pivotal region lead-associated impairment.
Language: Английский
Citations
0
Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0