Progress in brain research, Journal Year: 2023, Volume and Issue: unknown, P. 61 - 77
Published: Jan. 1, 2023
Language: Английский
Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 182, P. 44 - 56
Published: Feb. 11, 2022
Depression is the most common mental disorder and a leading cause of disability worldwide. Despite abundant research, precise mechanisms underlying pathophysiology depression remain elusive. Accumulating evidence from preclinical clinical studies suggests that alterations in gut microbiota, microbe-derived short-chain fatty acids, D-amino acids metabolites play key role via brain–gut–microbiota axis, including neural immune systems. Notably, axis might crucial susceptibility versus resilience rodents exposed to stress. Vagotomy reported block depression-like phenotypes after fecal microbiota transplantation "depression-related" microbiome, suggesting vagus nerve influences through axis. In this article, we review recent findings regarding discuss its potential as therapeutic target for depression.
Language: Английский
Citations
246
Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(3), P. 1618 - 1629
Published: Nov. 24, 2021
Abstract ( R,S )-ketamine elicits rapid-acting and sustained antidepressant actions in treatment-resistant patients with depression. R produces longer-lasting effects than S rodents; however, the precise molecular mechanisms underlying of remain unknown. Using isobaric Tag for Relative Absolute Quantification, we identified nuclear receptor-binding protein 1 (NRBP1) that could contribute to different antidepressant-like two enantiomers chronic social defeat stress (CSDS) model. NRBP1 was localized microglia neuron, not astrocyte, mouse medial prefrontal cortex (mPFC). increased expression NRBP1, brain-derived neurotrophic factor (BDNF), phosphorylated cAMP response element binding (p-CREB)/CREB ratio primary cultures thorough extracellular signal-regulated kinase (ERK) activation. Furthermore, activate BDNF transcription through activation CREB as well MeCP2 (methyl-CpG 2) suppression microglia. Single intracerebroventricular (i.c.v.) injection CREB-DNA/RNA heteroduplex oligonucleotides (CREB-HDO) or exon IV-HDO blocked CSDS susceptible mice. Moreover, microglial depletion by colony-stimulating receptor (CSF1R) inhibitor PLX3397 In addition, inhibition single i.c.v. mannosylated clodronate liposomes (MCLs) significantly Finally, CREB-HDO, MCLs beneficial on reduced dendritic spine density mPFC These data suggest a novel ERK-NRBP1-CREB-BDNF pathways )-ketamine.
Language: Английский
Citations
161
Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 182, P. 130 - 140
Published: Feb. 12, 2022
The spleen, an important tissue for the immune system, acts as a filter blood within system. Accumulating evidence suggests that spleen affects number of brain functions in health and diseases via modulation. Systemic inflammation or chronic social defeat stress (CSDS) can cause splenomegaly rodents. Interestingly, new antidepressant arketamine could normalize depression-like behaviors CSDS-susceptible mice. A recent study strongly supports direct connection pathway between whereby regulate humoral defense by two regions, such corticotropin-related neurons paraventricular nucleus (PVN) central amygdala (CeA). Furthermore, afferent efferent vagus nerve signaling may contribute to communication. In this article, we review findings brain-spleen axis diseases.
Language: Английский
Citations
88
JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(12), P. e2244514 - e2244514
Published: Dec. 1, 2022
Importance Postoperative sleep disturbance (PSD) is common in patients after surgery. Objective To examine the effect of intraoperative esketamine infusion on incidence PSD who underwent gynecological laparoscopic Design, Setting, and Participants This single-center, double-blind, placebo-controlled randomized clinical trial was conducted from August 2021 to April 2022 First Affiliated Hospital Zhengzhou University China. included aged 18 65 years with an American Society Anesthesiologist Physical Status classification I III (with indicating a healthy patient, II patient mild systemic disease, severe disease) Patients were randomly assigned either group or control group. Data analyzed using per protocol principle. Interventions received continuous esketamine, 0.3 mg/kg/h, intraoperatively. equivalent volume saline. Main Outcomes Measures The primary outcome postoperative days (PODs) 1 3. defined as numeric rating scale score 6 higher Athens Insomnia Scale points higher. secondary outcomes anxiety depression scores Anxiety Depression Scale, pain visual analog scale, hydromorphone consumption, risk factors associated PSD. Results A total 183 female (n = 91; median [IQR] age, 45 [35-49] years) 92; 43 [32-49] years). significantly lower than POD (22.8% vs 44.0%; odds ratio [OR], 0.38 [95% CI, 0.20-0.72]; P .002) 3 (7.6% 19.8%; OR, 0.33 0.13-0.84]; .02). There no differences between 2 groups. consumption first 24 hours (3.0 [range, 2.8-3.3] mg 3.2 2.9-3.4] mg; .04) movement (3 [3-4] 4 [3-5] points; < .001) On multivariable logistic regression, preoperative (OR, 1.31; 95% 1.01-1.70) 1.67; 1.04-1.80) scores, duration anesthesia 1.04; 1.00-1.08), 1.92; 1.24-2.96) identified Conclusions Relevance this showed prophylactic Further studies are needed confirm these results. Trial Registration Chinese Clinical Registry Identifier: ChiCTR2100048587
Language: Английский
Citations
76
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(9), P. 3625 - 3637
Published: Sept. 1, 2023
Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.
Language: Английский
Citations
51
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 565 - 565
Published: April 9, 2023
The gut microbiota is critical for maintaining human health and the immunological system. Several neuroscientific studies have shown significance of in developing brain systems. are interconnected a bidirectional relationship, as research on microbiome–gut–brain axis shows. Significant evidence links anxiety depression disorders to community microbes that live gastrointestinal Modified diet, fish omega-3 fatty acid intake, macro- micro-nutrient prebiotics, probiotics, synbiotics, postbiotics, fecal transplantation, 5-HTP regulation may all be utilized alter treatment approach. There few preclinical clinical effectiveness reliability various therapeutic approaches anxiety. This article highlights relevant association with different possibilities modification.
Language: Английский
Citations
49
General Psychiatry, Journal Year: 2024, Volume and Issue: 37(1), P. e101374 - e101374
Published: Feb. 1, 2024
The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing microbiota-gut-brain axis, its metabolites regulate central nervous system through neural, endocrine immune pathways to ensure normal functioning of organism, tuning individuals’ health disease status. Short-chain fatty acids (SCFAs), main bioactive microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component axis In present review, roles major (acetate, propionate butyrate) pathophysiology depression summarised with respect chronic cerebral hypoperfusion, neuroinflammation, host epigenome neuroendocrine alterations. Concluding remarks biological mechanisms related will hopefully address clinical value microbiota-related treatments for
Language: Английский
Citations
34
European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 27, 2024
The growing interest in the rapid and sustained antidepressant effects of dissociative anesthetic ketamine classic psychedelics, such as psilocybin, is remarkable. However, both psychedelics are known to induce acute mystical experiences; can cause symptoms out-of-body experience, while typically bring about hallucinogenic experiences, like a profound sense unity with universe or nature. role these experiences enhancing outcomes for patients depression currently an area ongoing investigation debate. Clinical studies have shown that following administration (S)-ketamine (esketamine) not directly linked their properties. In contrast, potential (R)-ketamine (arketamine), thought lack side effects, has yet be conclusively proven large-scale clinical trials. Moreover, although activation serotonin 5-HT
Language: Английский
Citations
29
BMJ, Journal Year: 2024, Volume and Issue: unknown, P. e078218 - e078218
Published: April 10, 2024
Abstract Objective To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression. Design Randomised, double blind, placebo controlled trial two parallel arms. Setting Five tertiary care hospitals China, 19 June 2020 to 3 August 2022. Participants 364 aged ≥18 years who had at least mild as indicated by Edinburgh postnatal scale scores ≥10 (range 0-30, higher indicating worse depression) and were admitted hospital for delivery. Interventions randomly assigned 1:1 receive either 0.2 mg/kg or infused intravenously over 40 minutes once the umbilical cord been clamped. Main outcome measures The primary was prevalence major depressive episode 42 days post partum, diagnosed using mini-international neuropsychiatric interview. Secondary outcomes included score seven partum 17 item Hamilton rating 0-52, depression). Adverse events monitored until 24 hours childbirth. Results A total (mean age 31.8 (standard deviation 4.1) years) enrolled randomised. At observed 6.7% (12/180) participants group compared 25.4% (46/181) (relative risk 0.26, 95% confidence interval (CI) 0.14 0.48; P<0.001). lower (median difference −3, CI −4 −2; P<0.001) (−3, also (−4, −6 −3; overall incidence adverse (45.1% (82/182) v 22.0% (40/182); P<0.001); however, symptoms lasted less than day none required drug treatment. Conclusions For depression, decreases episodes about three quarters. Neuropsychiatric more frequent but transient did not require intervention. Trial registration ClinicalTrials.gov NCT04414943 .
Language: Английский
Citations
25
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(3), P. e240953 - e240953
Published: March 6, 2024
Importance Postpartum depression (PPD) is one of the most common mental health conditions during perinatal and postpartum periods, which can have adverse effects on both mother infant. Objective To investigate efficacy perioperative adjunctive esketamine administration after cesarean deliveries in prevention PPD. Design, Setting, Participants A single-center, double-blind, placebo-controlled, randomized clinical trial was conducted from January 1, 2022, to 2023, at Fujian Provincial Hospital among 298 women aged 18 40 years, with an American Society Anesthesiologists grade I III classification singleton full-term pregnancies who were scheduled for elective deliveries. Primary analyses performed a modified intention-to-treat basis. Interventions Patients randomly assigned (n = 148) control 150) groups. Those group received single intravenous injection 0.25 mg/kg immediately fetal delivery, followed by 50 mg as adjuvant patient-controlled analgesia 48 hours surgery. Saline given patients. Main Outcomes Measures The primary outcome assessments PPD symptoms using Edinburgh Postnatal Depression Scale (EPDS) day 7. Positive screening defined score 10 or more points EPDS. In addition, EPDS analyzed continuous variable evaluate depressive symptoms. Secondary outcomes included Numeric Rating (NRS) postoperative pain, along safety evaluations including events days 14, 28, 42. Results total pregnant included, 150 (median age, 31.0 years [IQR, 29.0-34.0 years]) 148 28.0-34.0 years]). prevalence significantly lower patients compared controls (23.0% [34 148] vs 35.3% [53 150]; odds ratio, 0.55; 95% CI, 0.33-0.91; P .02) also showed change scores (difference least-squares means [SE], −1.17 [0.44]; −2.04 −0.31; effect size, 0.74; .008). However, there no differences between groups incidence positive results changes baseline There NRS rest movement except 72 postoperatively, when (median, 3.0 2.0-3.0] 3.0-3.5]; median difference, 0 [95% 0-0]; .03). Conclusions Relevance These suggest that period delivery improve early period. this antidepression may not be universally applicable low scores. Trial Registration Chinese Clinical Registry Identifier: ChiCTR2100054199
Language: Английский
Citations
20