Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain DOI Creative Commons
Vito S. Hernández, Mario A. Zetter, Oscar R. Hernández‐Pérez

et al.

Journal of Neuroendocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Kisspeptinergic signaling is well‐established as crucial for the regulation of reproduction, but its potential broader role in brain function less understood. This study investigates distribution and chemotyping kisspeptin‐expressing neurons within mouse brain. RNAscope single, dual, multiplex situ hybridization methods were used to assess kisspeptin mRNA ( Kiss1 ) expression co‐expression with other neuropeptides, excitatory inhibitory neurotransmitter markers, sex steroid receptors wild‐type intact gonadectomized young adult mice. Seven distinct neuronal chemotypes characterized, including two novel groups described first time, that is, population ventral premammillary nucleus solitary tract. was also observed localize both somatic dendritic compartments hypothalamic neurons. High androgen receptor changes medial amygdala septo‐hypothalamic following GDX males, not females, suggest a regulating signaling. provides detailed chemoanatomical map neurons, highlighting their functional diversity. The discovery new group gonadectomy‐induced patterns roles functions beyond those reproduction.

Language: Английский

Social trauma engages lateral septum circuitry to occlude social reward DOI Creative Commons
Long Li, Romain Durand-de Cuttoli, Antonio Aubry

et al.

Nature, Journal Year: 2022, Volume and Issue: 613(7945), P. 696 - 703

Published: Nov. 30, 2022

Abstract In humans, traumatic social experiences can contribute to psychiatric disorders 1 . It is suggested that trauma impairs brain reward function such behaviour no longer rewarding, leading severe avoidance 2,3 rodents, the chronic defeat stress (CSDS) model has been used understand neurobiology underlying susceptibility versus resilience following trauma, yet little known regarding its impact on 4,5 Here we show that, CSDS, a subset of male and female mice, termed susceptible (SUS), avoid interaction with non-aggressive, same-sex juvenile C57BL/6J mice do not develop context-dependent encounters them. Non-social stressors have effect in either sex. Next, using whole-brain Fos mapping, vivo Ca 2+ imaging whole-cell recordings, identified population stress/threat-responsive lateral septum neurotensin (NT LS ) neurons are activated by interactions only SUS but resilient or unstressed control mice. Optogenetic chemogenetic manipulation NT their downstream connections modulates reward. Together, these data suggest previously rewarding targets possibly perceived as threats resulting from hyperactive occlude processing.

Language: Английский

Citations

98
Experience-dependent dopamine modulation of male aggression DOI
Bing Dai,

Bingqin Zheng,

X. C. Dai

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

3
Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species DOI Creative Commons
Robert A. Phillips, Seyun Oh, Svitlana V. Bach

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111820 - 111820

Published: Jan. 18, 2025

The lateral septum (LS) is a midline, subcortical structure that critical regulator of social behaviors. Mouse studies have identified molecularly distinct neuronal populations within the LS, which control specific facets behavior. Despite its known molecular heterogeneity in mouse and role regulating behavior, comprehensive profiling human LS has not been performed. Here, we conducted single-nucleus RNA sequencing (snRNA-seq) to generate transcriptomic profiles compared recently collected snRNA-seq datasets. Our analyses TRPC4 as conserved marker while FREM2 enriched only LS. We also identify cell type marked by OPRM1, gene encoding μ-opioid receptor. Together, these results highlight transcriptional robust genes for

Language: Английский

Citations

2
Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula DOI Creative Commons

Muran Wang,

Peijun Li, Zewen Li

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 5, 2023

Major depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum (LS) is thought to control depression, however, cellular circuit substrates largely unknown. Here, we identified subpopulation LS GABAergic adenosine A

Language: Английский

Citations

39
Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice DOI Creative Commons
Noelia S. de León-Reyes, Paula Sierra Díaz, Ramon Nogueira

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(19), P. 4152 - 4171.e31

Published: Sept. 1, 2023

Language: Английский

Citations

35
Prefrontal modulation of anxiety through a lens of noradrenergic signaling DOI Creative Commons

Nadia N. Bouras,

Nancy R. Mack, Wen‐Jun Gao

et al.

Frontiers in Systems Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: April 17, 2023

Anxiety disorders are the most common class of mental illness in U.S., affecting 40 million individuals annually. is an adaptive response to a stressful or unpredictable life event. Though evolutionarily thought aid survival, excess intensity duration anxiogenic can lead plethora adverse symptoms and cognitive dysfunction. A wealth data has implicated medial prefrontal cortex (mPFC) regulation anxiety. Norepinephrine (NE) crucial neuromodulator arousal vigilance believed be responsible for many anxiety disorders. NE synthesized locus coeruleus (LC), which sends major noradrenergic inputs mPFC. Given unique properties LC-mPFC connections heterogeneous subpopulation neurons known involved regulating anxiety-like behaviors, likely modulates PFC function cell-type circuit-specific manner. In working memory stress response, follows inverted-U model, where overly high low release associated with sub-optimal neural functioning. contrast, based on current literature review individual contributions disorders, we propose model level- adrenergic receptor-dependent, NE-PFC modulation Further, advent new techniques measure unprecedented spatial temporal resolution will significantly help us understand how

Language: Английский

Citations

27
Cellular and circuit architecture of the lateral septum for reward processing DOI
Gaowei Chen,

Shishi Lai,

Shaolei Jiang

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(16), P. 2783 - 2798.e9

Published: July 2, 2024

Language: Английский

Citations

9
The neural basis of affective empathy: what is known from rodents DOI

Sicong Peng,

Moyi Li,

Xiuqi Yang

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110347 - 110347

Published: Feb. 1, 2025

Language: Английский

Citations

1
Opioid-driven disruption of the septal complex reveals a role for neurotensin-expressing neurons in withdrawal DOI Creative Commons
Rhiana C. Simon, Weston Fleming,

P. Senthilkumar

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Because opioid withdrawal is an intensely aversive experience, persons with use disorder (OUD) often relapse to avoid it. The lateral septum (LS) a forebrain structure that important in aversion processing, and previous studies have linked the substance disorders. It unclear, however, which precise LS cell types might contribute maladaptive state of withdrawal. To address this, we used single-nucleus RNA-sequencing interrogate type specific gene expression changes induced by chronic morphine We discovered globally disrupted transcriptional profile types, but Neurotensin-expressing neurons (

Language: Английский

Citations

8
Multimodal classification of neurons in the lateral septum DOI Creative Commons
Christopher M. Reid,

Yuqi Ren,

Yajun Xie

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

ABSTRACT The lateral septum (LS) is a nucleus in the ventral forebrain that modulates complex social and affective behaviors. Several distinct neuronal types have been described LS; however, full extent of this cellular molecular diversity remains unclear. We address gap by profiling transcriptional identity mature LS neurons originating from two progenitor lineages defined their anatomical location expression transcription factor Nkx2.1 . describe 12 molecularly subtypes fall into main groups: those with history without. discovered lineage share an enrichment select cell adhesion communication molecules. Despite this, we found developmental origins can exhibit significant similarities. then examined spatial relationships among LS, revealing each subtype occupies discrete domain. These domains are graded patterns gene correlate taxonomy neuron encode proteins involved synaptic signaling. Lastly, genetically labeled non-overlapping subgroups neurons, detailed connective, morphological, electrophysiological properties. Our findings offer deeper understanding heterogeneity paving way for future studies how these contribute to regulating emotional motivated

Language: Английский

Citations

6