Robotic animals as new tools in rodent neuroscience research: proposed applications of zooinspired robots for mouse behavioral testing DOI Creative Commons
Raffaele d’Isa

Frontiers in Behavioral Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 24, 2025

Bioinspired robots are machines which reproduce structural or functional features of a living organism. In particular, the bioinspired animals can be more specifically defined as zooinspired robots. Currently, applications animal various and range across different fields, such as, for instance, nature conservation, search rescue humans after natural man-made disasters, exploration extraterrestrial environments robotic pets elderly people under care dementia. Several species have been imitated up to now, from lizards butterflies, fish dogs. Animal used investigate social behavior an through animal-robot interactions called ethorobots. Intriguingly, ethorobots able in laboratory behaviors that generally produced spontaneously difficult impossible evoke modulate captive animals, makes these particularly useful tools experimental ethology ethological neuroscience. Rodents, primarily mice rats, most common model biomedical research. Coherently with importance scientific research, rats attracting increasing efforts robotics over course past five decades. The technological advancement will make their employment research increasingly useful. However, clear should identified order challenge engineers design serve scopes. present work, we describe possible practical mouse behavioral testing six domains, namely courtship, parental care, antipredatory behavior, helping predation territory defense-related aggression. outline how could employed interact series specific tests behavior. Finally, conclusion consider ethical epistemological advantages use Indeed, benefit on both terms optimized welfare tested subjects extended opportunities designing due unprecedented control independent variables.

Language: Английский

Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience DOI
Nastacia L. Goodwin,

Jia Jie Choong,

Sophia Hwang

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(7), P. 1411 - 1424

Published: May 22, 2024

Language: Английский

Citations

71
The Edge of Sentience DOI
Jonathan Birch

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract Can octopuses feel pain and pleasure? What about crabs, shrimps, insects, or spiders? How do we tell whether a person unresponsive after severe brain injury might be suffering? When does fetus in the womb start to have conscious experiences? Could there even rudimentary feelings miniature models of human brain, grown from stem cells? And what AI? These are questions edge sentience, they subject enormous, disorienting uncertainty. The stakes immense, neglecting risks can terrible costs. We need err on side caution, yet it’s often far clear ‘erring caution’ should mean practice. going too far? not doing enough? Edge Sentience presents comprehensive precautionary framework designed help us reach ethically sound, evidence-based decisions despite our

Language: Английский

Citations

17
The impact of adult neurogenesis on affective functions: of mice and men DOI Creative Commons
Mariana Alonso, Anne‐Cécile Petit, Pierre‐Marie Lledo

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(8), P. 2527 - 2542

Published: March 18, 2024

In most mammals, new neurons are not only produced during embryogenesis but also after birth. Soon adult neurogenesis was discovered, the influence of recruiting on cognitive functions, especially memory, documented. Likewise, late process neuronal production contributes to affective this outcome recognized with more difficulty. This review covers hypes and hopes discovering newly-generated brain circuits devoted functions. If possibility integrating into is a commonly accepted faculty in realm reluctance strong when it comes translating concept humans. Compiling data suggest now that derived from stem cells, population neuroblasts displaying protracted maturation ready be engaged circuits, under specific signals. Here, we discuss significance specifically context outcomes. We fact could ultimate cellular integrates elements both internal external environment adjust While must critical beware unreal promises Science generate sometimes, important continue exploring potential neural recruitment primates. Reporting humankind vision humans as mammals whose continues develop throughout life. peculiar one day become target treatment for mental health, disorders, elderly-associated diseases. The an which never stops real game changer designing therapeutic interventions treat disorders associated substantial morbidity, mortality, social costs.

Language: Английский

Citations

12
NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA DOI
Nan Song, Zhenhong Liu, Yan Gao

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(5), P. 1550 - 1566

Published: Feb. 15, 2024

Language: Английский

Citations

10
Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies DOI
Nancy R. Mack,

Nadia N. Bouras,

Wen‐Jun Gao

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(2), P. 85 - 94

Published: March 13, 2024

Language: Английский

Citations

9
The first rodent behavioral study (1822) and the diffusion of human-bred albino rats and mice in the 19th century DOI Creative Commons
Raffaele d’Isa

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 3, 2025

Rodents, in particular rats and mice, are currently the most widely employed animal models psychology behavioral neuroscience. Nevertheless, an interesting historical question is: when was first rodent study performed by whom? The current article presents history of science: a case interspecies social bonding between rat dog, observed 1822 British chemist Samuel Moss (1794–1868) subsequently described same scientific 1836. In present article, after biographical sketch Moss, I examine detail notable Moss. This is under several points view. First, Moss’s albino, variety which at that time extremely rare. Moreover, time, Western world were mostly seen as pest animals or baits for rat-catching sports, not kept pets. color played key role its fate, being reason it originally brought to decided keep his care. Third, relationship arose dog even more surprising if we consider trained rat-catcher. Importantly, this rat-dog case, showcased tameness albino both lay publications, represented popularization docility rats. After having outlined considering importance our society, research (where has become prototype laboratory rat) pets, provide contextualization regarding rodents, starting from 17th century, then trace post-Moss diffusion human-bred mice 19th century.

Language: Английский

Citations

1
Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment DOI Creative Commons
Carina Seah, Anne Elizabeth Sidamon‐Eristoff, Laura M. Huckins

et al.

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(5)

Published: March 2, 2025

Exposure to traumatic stress is common in the general population. Variation brain's molecular encoding of potentially contributes heterogeneous clinical outcomes response experiences. For instance, only a minority those exposed trauma will develop post-traumatic disorder (PTSD). Risk for PTSD at least partially heritable, with growing number genetic factors identified through GWAS. A major limitation studies that they capture component risk, whereas by definition requires an environmental exposure. Furthermore, extent, timing, and type affects susceptibility. Here, we discuss mechanisms risk together gene × environment interactions, focus on how either might inform screening individuals high disease, reveal biological one day yield novel therapeutics, impact best practices even today. To close, interaction sex, gender, race, implications treatment. Altogether, suggest predicting, preventing, treating require integrating both genotypic information.

Language: Английский

Citations

1
Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning DOI Creative Commons
Joeri Bordes, Lucas Miranda, Bertram Müller‐Myhsok

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 151, P. 105243 - 105243

Published: May 22, 2023

Social behavior is naturally occurring in vertebrate species, which holds a strong evolutionary component and crucial for the normal development survival of individuals throughout life. Behavioral neuroscience has seen different influential methods social behavioral phenotyping. The ethological research approach extensively investigated natural habitats, while comparative psychology was developed utilizing standardized univariate tests. advanced precise tracking tools, together with post-tracking analysis packages, recently enabled novel phenotyping method, that includes strengths both approaches. implementation such will be beneficial fundamental but also enable an increased understanding influences many factors can influence behavior, as stress exposure. Furthermore, future increase number data modalities, sensory, physiological, neuronal activity data, thereby significantly enhance our biological basis guide intervention strategies abnormalities psychiatric disorders.

Language: Английский

Citations

18
Behavioral neuroscience’s inevitable SABV growing pains DOI
Rebecca M. Shansky

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(9), P. 669 - 676

Published: July 20, 2024

Language: Английский

Citations

7
A unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior DOI Creative Commons
Jonathan P. Newman, Jie Zhang, Aarón Cuevas-López

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Behavioral neuroscience faces two conflicting demands: long-duration recordings from large neural populations and unimpeded animal behavior. To meet this challenge, we developed ONIX, an open-source data acquisition system with high throughput (2GB/sec) low closed-loop latencies (<1ms) that uses a novel 0.3 mm thin tether to minimize behavioral impact. Head position rotation are tracked in 3D used drive active commutation without torque measurements. ONIX can acquire combinations of passive electrodes, Neuropixels probes, head-mounted microscopes, cameras, 3D-trackers, other sources. We perform uninterrupted, long (~7 hours) mice as they traversed complex 3-dimensional terrain. allowed exploration similar mobility non-implanted animals, contrast conventional tethered systems which restricted movement. By combining full mobility, our technology will enable new progress on questions require high-quality during ethologically grounded behaviors.

Language: Английский

Citations

14