Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(4), P. 433 - 433
Published: Feb. 11, 2025
Irritable
bowel
syndrome
(IBS)
is
one
of
the
most
common
functional
gastrointestinal
disorders
diagnosed
in
children.
It
has
a
complex
pathophysiology
with
several
potential
risk
factors,
including
psychological
like
anxiety
and
depression.
This
paper
aimed
to
find
genetic,
pathophysiological,
clinical
links
between
factors
(mainly
depression)
IBS
Impairment
gut-brain
communication
signalling
serotonin
responsible
for
both
disorders.
Childhood
events
seem
be
linked
symptoms
not
only
childhood
but
also
adulthood.
Evidence
efficacy
therapies
targeting
(antidepressant,
hypnotherapy,
cognitive
behavioural
therapy)
children
was
evaluated.
Further
studies
that
use
updated
criteria
uniform
questionnaires
outcome
measures
are
needed
draw
reliable
conclusions
regarding
connection
IBS.
Immunology,
Journal Year:
2024,
Volume and Issue:
172(1), P. 1 - 20
Published: Jan. 4, 2024
Irritable
bowel
syndrome
(IBS),
one
of
the
most
prevalent
functional
gastrointestinal
disorders,
is
characterized
by
recurrent
abdominal
pain
and
abnormal
defecation
habits,
resulting
in
a
severe
healthcare
burden
worldwide.
The
pathophysiological
mechanisms
IBS
are
multi-factorially
involved,
including
food
antigens,
visceral
hypersensitivity
reactions,
brain–gut
axis.
Numerous
studies
have
found
that
gut
microbiota
intestinal
mucosal
immunity
play
an
important
role
development
crosstalk
with
multiple
mechanisms.
Therefore,
based
on
existing
evidence,
this
paper
elaborates
damage
activation
disturbance
closely
related
to
progression
IBS.
Combined
application
prospect,
it
also
provides
references
for
further
in-depth
exploration
clinical
practice.
Personality Neuroscience,
Journal Year:
2023,
Volume and Issue:
6
Published: Jan. 1, 2023
Abstract
We
examine
some
of
the
genetic
features
neuroticism
(N)
taking
as
an
animal
model
Maudsley
Reactive
(MR)
and
Nonreactive
(MNR)
rat
strains
which
were
selectively
bred,
respectively,
for
high
low
open-field
defecation
(OFD)
starting
in
late
1950s.
To
draw
analogies
with
human
studies,
we
explore
correlation
N
irritable
bowel
syndrome
(IBS).
review
progress
developments
field
complex
trait
genetics,
including
association
studies
that
relate
to
current
understanding
genetics
N.
The
widespread
differences
tone
peripheral
sympathetic
nervous
system
have
been
found
between
strains,
particularly
those
observed
colon,
may
underly
OFD
(MNR,
higher
zero
defecation).
In
humans,
a
large
genome-wide
study
(GWAS)
reported
six
genes
contributing
IBS,
four
implicated
mood
anxiety
disorders
or
expressed
brain,
three
also
nerve
fibers
ganglia
gut.
Heritability
is
estimated
at
around
50%
twin
family
GWASs
identified
hundreds
loci,
enabling
estimation
correlations
(r
g
)
other
traits.
Significantly,
estimate
r
risk
anxiety,
N,
depression
was
>0.5
suggested
pleiotropy
without
evidence
causal
mechanisms.
Findings
on
adrenergic
pharmacology
coupled
new
role
locus
ceruleus
modifying
afferent
information
from
this
organ,
generate
hypotheses
challenge
traditional
cause/effect
notions
about
relationship
central
events
response
stress,
suggest
specific
targets
gene
action
emphasize
value
reciprocal
evaluation
architecture
underlying
rodents
humans.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 21, 2024
The
bidirectional
communication
between
the
gut
and
brain
or
gut-brain
axis
is
regulated
by
several
microbes
microbial
derived
metabolites,
such
as
short-chain
fatty
acids,
trimethylamine
N-oxide,
lipopolysaccharides.
Gut
microbiota
(GM)
produce
neuroactives,
specifically
neurotransmitters
that
modulates
local
central
neuronal
functions.
An
imbalance
intestinal
commensals
pathobionts
leads
to
a
disruption
in
dysbiosis,
which
affects
barrier
integrity
gut-immune
neuroimmune
systems.
Currently,
fecal
transplantation
(FMT)
recommended
for
treatment
of
recurrent
Cellular and Molecular Gastroenterology and Hepatology,
Journal Year:
2024,
Volume and Issue:
18(1), P. 1 - 13
Published: Jan. 1, 2024
Significant
strides
have
been
made
in
brain-gut-microbiome
research
over
the
past
six
years,
fueled
by
technological
breakthroughs
and
discovery
of
new
mechanistic
pathways.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(13), P. 2114 - 2114
Published: July 2, 2024
Irritable
bowel
syndrome
(IBS)
is
a
common
gastrointestinal
disorder
with
gut
microbiota
imbalance
playing
significant
role.
There
are
increasing
numbers
of
research
studies
exploring
treatment
options
involving
probiotics,
prebiotics,
synbiotics,
and
fecal
transplantation
(FMT),
but
it
still
uncertain
which
option
superior.
The
was
conducted
on
various
databases
unpublished
trial
data
(up
to
February
2023).
Randomized
controlled
trials
(RCTs)
were
screened
for
adult
patients
IBS
comparing
interventions
placebo.
Probiotics,
FMT
assessed
their
impact
using
mean
difference
Bayesian
network
meta-analysis.
Out
6528
articles,
54
included
7
prebiotics/synbiotics,
6
FMT.
Probiotics
showed
improvement
in
symptoms,
particularly
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: Jan. 5, 2024
Increasing
evidence
links
the
gut
microbiome
and
nervous
system
in
health
disease.
This
narrative
review
discusses
current
views
on
interaction
between
microbiota,
intestinal
epithelium,
brain,
provides
an
overview
of
communication
routes
signals
bidirectional
interactions
microbiota
including
circulatory,
immunological,
neuroanatomical,
neuroendocrine
pathways.
Similarities
differences
healthy
humans
mice
exist
that
are
relevant
for
translational
gap
non-human
model
systems
patients.
There
is
increasing
spectrum
metabolites
neurotransmitters
released
and/or
modulated
by
both
homeostatic
pathological
conditions.
Dysbiotic
disruptions
occur
as
consequences
critical
illnesses
such
cancer,
cardiovascular
chronic
kidney
disease
but
also
neurological,
mental,
pain
disorders,
well
ischemic
traumatic
brain
injury.
Changes
(dysbiosis)
a
concomitant
imbalance
release
mediators
may
be
cause
or
consequence
diseases
central
increasingly
emerging
to
disruption
physiological
function,
alterations
nutrition
intake,
exposure
hypoxic
conditions
others,
observed
disorders.
Despite
generally
accepted
importance
microbiome,
not
fully
understood.
Elucidating
these
signaling
pathways
more
detail
offers
novel
mechanistic
insight
into
pathophysiology
multifaceted
aspects
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: July 1, 2024
Functional
gastrointestinal
disorders
(FGIDs),
chronic
characterized
by
either
abdominal
pain,
altered
intestinal
motility,
or
their
combination,
have
a
worldwide
prevalence
of
more
than
40%
and
impose
high
socioeconomic
burden
with
significant
decline
in
quality
life.
Recently,
FGIDs
been
reclassified
as
gut-brain
interaction
(DGBI),
reflecting
the
key
role
bidirectional
communication
these
impact
on
psychological
comorbidities.
Although,
during
past
decades,
field
DGBIs
has
advanced
significantly,
molecular
mechanisms
underlying
pathogenesis
pathophysiology,
gut
microbiome
processes
are
not
fully
understood.
This
review
aims
to
discuss
latest
body
literature
complex
microbiota-gut-brain
interactions
implications
DGBIs.
A
better
understanding
existing
pathways
between
brain
holds
promise
developing
effective
therapeutic
interventions
for
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: April 13, 2024
Abstract
Visceral
hypersensitivity,
a
common
clinical
manifestation
of
irritable
bowel
syndrome,
may
contribute
to
the
development
chronic
visceral
pain,
which
is
major
challenge
for
both
patients
and
health
providers.
Neural
circuits
in
brain
encode,
store,
transfer
pain
information
across
regions.
In
this
review,
we
focus
on
anterior
cingulate
cortex
paraventricular
nucleus
hypothalamus
highlight
progress
identifying
neural
involved
pain.
We
also
discuss
several
circuit
mechanisms
emphasize
importance
cross-species,
multiangle
approaches
identification
specific
neurons
determining
that
control
