Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 526 - 539
Published: May 26, 2023
Language: Английский
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: June 27, 2024
The locus coeruleus (LC), our main source of norepinephrine (NE) in the brain, declines with age and is a potential epicentre protein pathologies neurodegenerative diseases (ND). In vivo measurements LC integrity function are potentially important biomarkers for healthy ageing early ND onset. present study, high-resolution functional MRI (fMRI), reversal reinforcement learning task, dedicated post-processing approaches were used to visualise differences (N = 50). Increased responses observed during emotionally task-related salient events, subsequent accelerations decelerations reaction times, respectively, indicating context-specific adaptive engagement LC. Moreover, older adults exhibited increased activation compared younger adults, possible compensatory overactivation structurally declining ageing. Our study shows that assessment promising biomarker cognitive aging.
Language: Английский
Citations
2
Annals of Neurology, Journal Year: 2024, Volume and Issue: 96(4), P. 650 - 661
Published: July 15, 2024
Objective Elevated entorhinal cortex (EC) tau in low beta‐amyloid individuals can predict accumulation of pathology and cognitive decline. We compared the accuracy magnetic resonance imaging (MRI)‐derived locus coeruleus integrity, neocortical burden by positron emission tomography (PET), hippocampal volume identifying elevated signal asymptomatic who are considered PET‐negative. Methods included 188 (70.78 ± 11.51 years, 58% female) underwent 3T‐MRI coeruleus, Pittsburgh compound‐B (PiB), Flortaucipir (FTP) PET. Associations between EC PiB, volume, or integrity were evaluated using logistic regression receiver operating characteristic analyses PiB− sample with a clinical dementia rating (CDR) 0. progression (CDR‐sum‐of‐boxes) over time span 6 years Cox proportional hazard models. Results identified 26 (21%) high FTP CDR = 0/PiB− sample. Locus was significantly more sensitive specific predictor (area under curve [AUC] 85%) PiB (AUC 77%) 76%). Based on Youden‐index, obtained sensitivity 77% 85% specificity. Using resulting Youden cut‐off, lower associated two‐fold increase progression, including mild impairment. Interpretation has promise as low‐cost, non‐invasive screening instrument to detect early cortical deposition asymptomatic, individuals. ANN NEUROL 2024;96:650–661
Language: Английский
Citations
2
Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(1), P. 105 - 111
Published: April 12, 2024
Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed Alzheimer's disease (AD). We investigated whether tangle neuronal density the rostral caudal LC characterized by an asymmetric pattern 77 autopsy cases Rush Memory Aging Project. found left-right equivalence for across individuals with without AD pathology. However, density, particularly caudal-rostral axis LC, among Asymmetry may signal advanced progression should be considered neuroimaging studies neurodegeneration.
Language: Английский
Citations
1
Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(7)
Published: July 1, 2024
Increased exposure to ambient air pollution, especially fine particulate matter
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 26, 2024
Abstract INTRODUCTION The Locus Coeruleus (LC) is linked to the development and pathophysiology of neurodegenerative diseases such as Alzheimer’s Disease (AD). Magnetic Resonance Imaging based LC features have shown potential assess integrity in vivo. METHODS We present a Deep Learning segmentation feature extraction method: ELSI-Net apply it healthy aging AD dementia datasets. Agreement expert raters previously published atlases were assessed. aimed reproduce reported differences correlate extracted cerebrospinal fluid (CSF) biomarkers pathology. RESULTS demonstrated high agreement atlases. Previously group detected correlations CSF found. DISCUSSION Although we found excellent performance, further evaluations on more diverse datasets from clinical cohorts are required for conclusive assessment ELSI-Nets general applicability. Highlights thorough evaluation fully automatic method termed outperforms previous work shows with manual ratings replicates ELSI-Net’s volume correlates pathology RESEARCH IN CONTEXT Systematic Review: authors reviewed literature using traditional sources (e.g. Pubmed, Google Scholar). there several publications introducing semi-automatic methods segmentation, application underexplored. To best our knowledge, this first paper approach automated dementia. Interpretation: Our introduces evaluates an improved automatic, analysis approach. results suggest very practical applicability, e.g. large-scale studies diseases. Future Directions: can be used large- or small-scale ensure robust should evaluated larger, comprising varying MRI protocols populations.
Language: Английский
Citations
1
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Alterations in locus coeruleus' (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across stages their functional relevance remains unknown.
Language: Английский
Citations
1
Brain Communications, Journal Year: 2024, Volume and Issue: 7(1)
Published: Dec. 24, 2024
Alzheimer's disease may be associated with early dopamine dysfunction. However, its effects on neurofunctional alterations in the neurotransmission pathways remain elusive. In this study, positron emission tomography atlases and functional MRI data for 86 older adults mild cognitive impairment (MCI), 58 disease-dementia 76 cognitively unimpaired were combined to investigate connectivity dopaminergic cholinergic systems. A cross-sectional design was used compare neurotransmitter-related across groups associations between performance. The findings show that dementia group showed a decline mesocorticolimbic dopamine-related precuneus but heightened thalamus, whereas disease-MCI nigrostriatal left temporal areas. Acetylcholine-related observed both primarily temporo-parietal Episodic memory scores correlated positively acetylcholine- cortex negatively fronto-thalamic This study shows acetylcholine parallel might clinically relevant marker disease.
Language: Английский
Citations
1
Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(6)
Published: June 1, 2024
Abstract The locus coeruleus–norepinephrine system plays a key role in supporting brain health along the lifespan, notably through its modulatory effects on neuroinflammation. Using ultra–high field diffusion magnetic resonance imaging, we examined whether microstructural properties (neurite density index and orientation dispersion index) coeruleus were related to those cortical subcortical regions, this was modulated by plasma glial fibrillary acidic protein levels, as proxy of astrocyte reactivity. In our cohort 60 healthy individuals (30 85 yr, 50% female), higher correlated with lower neurite frontal hippocampus, amygdala. Furthermore, under levels (above ~ 150 pg/mL for 145 regions), associated frontotemporal regions regions. Interestingly, exhibited these (sub)cortical despite having levels. Together, results suggest that interaction between cells astrocytes can signal detrimental or neuroprotective pathway integrity support importance maintaining neuronal aging prevention age-related neurodegenerative diseases.
Language: Английский
Citations
0
Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 147, P. 12 - 21
Published: Nov. 27, 2024
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 21, 2024
Abstract Interpreting ambiguous environmental cues, like facial expressions, becomes increasingly challenging with age, especially as cognitive resources decline. Managing these challenges requires adaptive neural mechanisms that are essential for maintaining mental well-being. The locus coeruleus (LC), the brain’s main norepinephrine source, regulates attention, arousal, and stress response. With extensive cortical connections, LC supports adapting to demands resolving conflicting cues from environment, particularly in later life. Previous research suggests interacts prefrontal cortex during high-conflict tasks. However, whether activity its connectivity PFC support emotional ambiguity processing contributes well-being healthy aging remains unclear. To address this gap, we used 7T-MRI examine function 75 younger (25.8±4.02years, 35females) 69 older adults (71.3±4.1 years, emotion-recognition task morphed varying ambiguity: anchor (unambiguous happy or fearful), intermediate- (30% happy–70% fearful 40%-happy–60% either direction), absolute-ambiguity (50% happy-fearful). Behaviorally, participants had longer response times lower confidence condition, while perceived faces more frequently than adults. Neuroimaging results revealed exhibited greater enhanced dorsolateral (dlPFC) compared This heightened was linked better resilience These findings suggest managing cognitively demanding tasks, LC-dlPFC helps maintain well- being, underscoring importance of pathway aging. Significance Statement Understanding how brain adapts age is key promoting study examined a region critical regulating attention undergoes changes task. Using ultra-high-field imaging, explored recognize expressions levels. Our indicated young, showed LC-dorsolateral when absolute-ambiguous improved higher LC- dlPFC resilience, offering insights into underlying
Language: Английский
Citations
0