Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 107129 - 107129
Published: Nov. 1, 2024
Language: Английский
Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 178 - 178
Published: Feb. 28, 2025
Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: Feb. 28, 2025
Introduction Post-stroke depression (PSD) is a prevalent neuropsychiatric disorder associated with impaired recovery in stroke survivors, potentially linked to dysregulation of brain-derived neurotrophic factor (BDNF). This study aimed establish novel animal model PSD by integrating ischemic brain injury chronic psychological stress. Methods Mice were subjected photochemically induced thrombosis (PIT) generate focal lesions the parietal lobe, followed restraint stress (CRS) simulate post-stroke Behavioral assessments (sucrose preference test, forced swim tail suspension test) and molecular analyses (BDNF, synaptophysin [SYP], interleukin-1 [IL-1], tumor necrosis factor- α [TNF- ]) conducted evaluate depressive-like phenotypes neuroinflammatory markers. Results The PIT produced consistent damage, an average infarct area 2.580 ± 0.426% lobe. exposed PIT-CRS exhibited significant behaviors, including reduced sucrose ( p < 0.001), increased immobility time test = 0.056), prolonged 0.168) compared Sham group. Molecular revealed marked downregulation BDNF 0.004) SYP 0.074), alongside upregulated IL-1 0.024) TNF-α 0.368) levels Conclusion provides comprehensive reproducible platform for studying PSD. By both stress, this captures multifaceted nature offers valuable insights into its pathophysiology. Future research using could pave way development targeted therapies
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 26, 2025
Major depressive disorder, also known as MDD, affects more than 264 million people globally, making it a prevalent and critical health challenge. Traditional treatments show limited efficacy in many patients. Therefore, exploring new treatment methods is particularly crucial. Mitophagy, regulatory process, can help understand treat MDD. This paper focuses on the molecular mechanisms of mitophagy, starting from proteins related pathways, its role The study explores associations between mitophagy neuroinflammation, oxidative stress, neurotransmitter synthesis, neuroplasticity MDD discusses progress clinical research In addition, article describes current pharmaceutical non-pharmaceutical interventions that regulate unravels potential challenges these therapeutic strategies settings. offers deeper insight into pathogenesis scientific basis for development strategies.
Language: Английский
Citations
0
Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(6), P. 659 - 684
Published: Oct. 21, 2024
Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and rise of long COVID. Viruses such Herpes Simplex Virus (HSV), Epstein-Barr (EBV), Cytomegalovirus (CMV), Human Immunodeficiency (HIV) linked to depression through complex neurobiological mechanisms. These include immune system dysregulation, chronic inflammation, neurotransmitter imbalances that affect brain function mood regulation. activation leads release pro-inflammatory cytokines, resulting in neuroinflammation associated symptoms. Furthermore, specific viruses can disrupt systems, including serotonin, dopamine, glutamate, all which essential stabilization. The unique interactions different with these systems underscore need virus-specific therapeutic approaches. Current broad-spectrum treatments often overlook precise pathways involved post-viral depression, reducing their efficacy. This review emphasizes understand create tailored interventions directly address effects induced by each type virus. may immunomodulatory target persistent antiviral therapies reduce viral load, or neuroprotective strategies restore balance. Precision medicine offers promising avenues effective management virus-induced providing patient-specific approaches biological mechanisms involved. By focusing on development targeted treatments, this aims pave way a new era psychiatric care fully addresses root causes infections.
Language: Английский
Citations
3
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 107129 - 107129
Published: Nov. 1, 2024
Language: Английский
Citations
1