Journal of Affective Disorders, Journal Year: 2021, Volume and Issue: 293, P. 254 - 260
Published: June 25, 2021
Language: Английский
Brain Behavior and Immunity, Journal Year: 2018, Volume and Issue: 74, P. 28 - 42
Published: Aug. 10, 2018
Resilience is the process that allows individuals to adapt adverse conditions and recover from them. This favored by individual qualities have been amply studied in field of stress such as personal control, positive affect, optimism, social support. Biopsychosocial studies on promote resilience show these factors help protect against deleterious influences stressors physiology general immunity particular. The reverse also true there evidence immune processes influence resilience. Most data supporting this relationship comes animal differences ability resist situations chronic stress. These build knowledge has accumulated brain behavior both human studies. In general, resilient a different immunophenotype susceptible individuals. It possible render vice versa changing their inflammatory phenotype. adaptive phenotype inflammation-induced symptoms. modulation bidirectional relationships between gut microbiota opens possibility them probiotics prebiotics. However, more focused reciprocal will be necessary before can put into practice.
Language: Английский
Citations
266
Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(3), P. 224 - 244
Published: Jan. 17, 2022
Over the past two decades, compelling evidence has emerged indicating that immune mechanisms can contribute to pathogenesis of major depressive disorder (MDD) and drugs with primary targets improve symptoms. Patients MDD are heterogeneous respect symptoms, treatment responses biological correlates. Defining a narrower patient group based on biology could increase response rates in certain subgroups: advance clinical psychiatry. For example, patients elevated pro-inflammatory biomarkers less likely respond conventional antidepressant drugs, but novel immune-based therapeutics potentially address their unmet needs. This article outlines framework for developing targeting subtype within reviews current state neuroimmune drug development mood disorders. We discuss causal role depression, together under investigation randomized controlled trials, biomarker elucidating link neural mechanisms, phenotypic selection strategies, need among MDD.
Language: Английский
Citations
210
Journal of Neuroinflammation, Journal Year: 2021, Volume and Issue: 18(1)
Published: Jan. 5, 2021
Abstract Background The NLRP3-mediated pyroptosis, which could be regulated by miRNA-27a, is a key player in the development of depression. Isoliquiritin phenolic flavonoid compound that has been demonstrated to suppress pyroptosis. However, it still unknown whether isoliquiritin confer antidepressant activity via decreasing pyroptosis stimulating miRNA-27a. Thus, current study, we explored and its underlying mechanism. Methods Expression miRNA-27a depressed patients or mice was measured using qRT-PCR. Luciferase reporter assay performed illustrate link between SYK. Lipopolysaccharide (LPS) chronic social defeat stress (CSDS) depression models were established investigate actions isoliquiritin. Changes miRNA-27a/SYK/NF-κB axis also examined. role isoliquiritin-related effect further investigated inhibitors mimics Results Our results showed expression downregulated serum patients, decreased hippocampus observed rodent SYK gene significantly reduced mimic incubation. profoundly attenuated LPS CSDS-induced depressive symptoms, as well anxiety behavior. In hippocampus, CSDS mRNA expression; increased protein levels SYK, p-NF-κB, NLRP3: cleaved Caspase-1, IL-1β, GSDMD-N: elevated concentration IL-6, TNF-α, all restored administration. Meanwhile, upregulated hippocampal NeuN level, improved survival morphology neurons, pyroptosis-related neuronal cell death. Moreover, protected primary microglia against adenosine triphosphate (ATP) elicited NLRP3 inflammasome activation vitro, evidenced declined NLRP3; GSDMD-N; Nevertheless, reversed isoliquiritin-generated therapeutic efficacy vitro. Furthermore, cytoprotective similar ATP-treated microglia. Taken together, these findings suggest possesses potent property, requires controlled decrease cascade.
Language: Английский
Citations
202
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12
Published: June 30, 2021
Osteoporosis is the most prevalent metabolic bone disease that affects half women in sixth and seventh decade of life. characterized by uncoupled resorption leads to low mass, compromised microarchitecture structural deterioration increases likelihood fracture with minimal trauma, known as fragility fractures. Several factors contribute osteoporosis men women. In women, menopause – cessation ovarian function, one leading causes primary osteoporosis. Over past three decades there has been growing appreciation adaptive immune system plays a fundamental role development postmenopausal osteoporosis, both humans mouse models. this review, we highlight recent data on interactions between T cells skeletal context Finally, review studies interventions ameliorate
Language: Английский
Citations
144
Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11
Published: Feb. 21, 2020
Many patients with cancer suffer from anemia, depression and an impaired quality of life (QoL). These often also show decreased plasma tryptophan levels increased kynurenine concentrations in parallel elevated Th1 type immune activation marker neopterin. In the course anti-tumor response, pro-inflammatory cytokine interferon gamma (IFN-𝛾) induces both, enzyme indoleamine 2,3-dioxygenase (IDO) to degrade GTP-cyclohydrolase I form High neopterin as well ratio (Kyn/Trp) blood are predictive for a worse outcome. Inflammation-mediated catabolism along pathway is related fatigue anemia QoL solid tumors. fact, enhanced breakdown might greatly contribute development patients. IDO stimulation exert regulatory mechanisms, which may impair responses. addition, tumor cells can weaken responses directed against them. expression tissue associated poor prognosis The efficiency IDO-inhibitors inhibit progression currently tested combination established chemotherapies checkpoint inhibitors. its possible influence on persistence discussed.
Language: Английский
Citations
142
Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 257, P. 108624 - 108624
Published: March 3, 2024
Language: Английский
Citations
18
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: Jan. 19, 2025
Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.
Language: Английский
Citations
5
Frontiers in Molecular Neuroscience, Journal Year: 2019, Volume and Issue: 12
Published: Sept. 11, 2019
The immune system is critically involved in the development and maintenance of chronic pain. However, T cells, one main regulators response, have only recently become a focus investigations on pain pathophysiology. Emerging clinical data suggest that patients with different phenotypic profile circulating cells compared to controls. At preclinical level, findings function are mixed differ between nerve injury, chemotherapy, inflammatory models persistent Depending type subset sex animal, may contribute onset and/or resolution pain, underlining as major player transition from acute Specific cell subsets release mediators such cytokines endogenous opioid peptides can promote, suppress, or even resolve Inhibiting pain-promoting functions enhancing beneficial effects pro-resolution offer new disease-modifying strategies for treatment critical need view current crisis.
Language: Английский
Citations
91
Pain, Journal Year: 2020, Volume and Issue: 161(10), P. 2344 - 2352
Published: May 13, 2020
Abstract Understanding the mechanisms that drive transition from acute to chronic pain is essential identify new therapeutic targets. The importance of endogenous resolution pathways acting as a “brake” prevent development has been largely ignored. We examined role interleukin-10 (IL-10) in neuropathic induced by cisplatin. In search an underlying mechanism, we studied effect cisplatin and IL-10 on spontaneous activity (SA) dorsal root ganglia neurons. Cisplatin (2 mg/kg daily for 3 days) mechanical hypersensitivity resolved within weeks. both sexes, was delayed Il10 −/− mice, WT mice treated intrathecally with neutralizing anti-IL-10 antibody, cell-targeted deletion IL-10R1 advillin-positive sensory Electrophysiologically, small- medium-sized neurons cisplatin-treated displayed increase incidence SA. treatment also depolarized resting membrane potential, decreased action potential voltage threshold rheobase, while increasing ongoing at −45 mV amplitude depolarizing fluctuations. vitro addition (10 ng/mL) reversed SA fluctuation amplitudes, but unexpectedly had little other electrophysiological parameters affected Collectively, our findings challenge prevailing concept resolves solely dampening neuroinflammation demonstrate model chemotherapy-induced prevents binding receptors regulate their activity.
Language: Английский
Citations
81
Autoimmunity Reviews, Journal Year: 2020, Volume and Issue: 19(5), P. 102504 - 102504
Published: March 13, 2020
Language: Английский
Citations
76