5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development DOI Creative Commons
Guilherme Shigueto Vilar Higa, José Fernando de Oliveira, Estêvão Carlos-Lima

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 5, 2022

Abstract Important functions of the prefrontal cortex (PFC) are established during early life, when neurons exhibit enhanced synaptic plasticity and synaptogenesis. This developmental stage drives organization cortical connectivity, responsible for establishing behavioral patterns. Serotonin (5-HT) emerges among most significant factors that modulate brain activity postnatal development. In PFC, activated 5-HT receptors modify neuronal excitability interact with intracellular signaling involved in modifications, thus suggesting might participate plasticity. To test this hypothesis, we employed electrophysiological recordings PFC layer 5 to study modulatory effects on induced by theta-burst stimulation (TBS) two periods rats. Our results indicate is essential TBS result changes third week, but not later. coupled 2A or 1A 7 leads long-term depression (LTD). On other hand, synergic activation , lead potentiation (LTP). Finally, also show dependent impaired animals exposed early-life chronic stress.

Language: Английский

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain DOI Creative Commons
Kaitlin C. Reeves, Nikhil Shah, Braulio Muñoz

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: June 15, 2022

Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, receptors are generally inhibitory, presynaptically reducing neurotransmitter release postsynaptically hyperpolarizing neurons. However, receptor-mediated regulation of function synaptic transmission is not uniform in expression pattern mechanism across brain. The localization within specific cell types neurocircuits determine that endogenous exogenous opioids have on brain function. In this review we will explore similarities differences neurotransmission different regions. We discuss how future studies can consider potential cell-type, regional, neural pathway-specific order to better understand modulate

Language: Английский

Citations

73
Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task DOI Creative Commons
Morten L. Kringelbach, Yonatan Sanz Perl, Enzo Tagliazucchi

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(2)

Published: Jan. 13, 2023

Identifying the functional specialization of brain has moved from using cognitive tasks and resting state to ecological relevant, naturalistic movies. We leveraged a large-scale neuroimaging dataset directly investigate hierarchical reorganization activity when watching films compared performing seven resting. A thermodynamics-inspired whole-brain model paradigm revealed generative underlying mechanisms for changing balance in causal interactions between regions different conditions. Paradoxically, hierarchy is flatter movie-watching, level nonreversibility significantly smaller comparison both rest tasks, where latter turn have highest levels nonreversibility. The were by model-based effective connectivity (GEC). Naturalistic could therefore provide fast convenient way measure important changes GEC (integrating anatomical connectivity) found in, example, neuropsychiatric disorders. Overall, this study demonstrates benefits moving toward more neuroscience.

Language: Английский

Citations

60
Interindividual Variability in Mental Fatigue-Related Impairments in Endurance Performance: A Systematic Review and Multiple Meta-regression DOI Creative Commons
Jelle Habay, Robin Uylenbroeck, Ruben Van Droogenbroeck

et al.

Sports Medicine - Open, Journal Year: 2023, Volume and Issue: 9(1)

Published: Feb. 20, 2023

Abstract Background The negative effect of mental fatigue (MF) on physical performance has recently been questioned. One reason behind this could lie in the interindividual differences MF-susceptibility and individual features influencing them. However, range fatigue-susceptibility is not known, there no clear consensus which be responsible for these differences. Objective To give an overview effects MF whole-body endurance performance, effect. Methods review was registered PROSPERO database (CRD42022293242). PubMed, Web Science, SPORTDiscus PsycINFO were searched until 16th June 2022 studies detailing dynamic maximal performance. Studies needed to include healthy participants, describe at least one feature participant characteristics, apply manipulation check. Cochrane crossover risk bias tool used assess bias. meta-analysis regression conducted R. Results Twenty-eight included, with 23 added meta-analysis. Overall included high, only three presenting unclear or low rating. shows average slightly ( g = − 0.32, [95% CI 0.46; 0.18], p < 0.001). multiple meta-regression showed significant influences (i.e. age, sex, body mass index fitness level) MF-susceptibility. Conclusions present confirmed impact identified. This can partially explained by methodological limitations such as underreporting lack standardization across studies, restricted inclusion potentially relevant variables. Future research should a rigorous description different (e.g., level, diet, etc.) further elucidate mechanisms.

Language: Английский

Citations

33
From neural circuits to communities: an integrative multidisciplinary roadmap for global mental health DOI Open Access
Michelle G. Craske, Mohammad M. Herzallah, Robin Nusslock

et al.

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(1), P. 12 - 24

Published: Jan. 17, 2023

Language: Английский

Citations

25
Machine Learning–Based Prediction of Suicidal Thinking in Adolescents by Derivation and Validation in 3 Independent Worldwide Cohorts: Algorithm Development and Validation Study DOI Creative Commons
Hyejun Kim, Yejun Son, Hojae Lee

et al.

Journal of Medical Internet Research, Journal Year: 2024, Volume and Issue: 26, P. e55913 - e55913

Published: May 17, 2024

Background Suicide is the second-leading cause of death among adolescents and associated with clusters suicides. Despite numerous studies on this preventable death, focus has primarily been single nations traditional statistical methods. Objective This study aims to develop a predictive model for adolescent suicidal thinking using multinational data sets machine learning (ML). Methods We used from Korea Youth Risk Behavior Web-based Survey 566,875 aged between 13 18 years conducted external validation 103,874 Norway’s University National General 19,574 adolescents. Several tree-based ML models were developed, feature importance Shapley additive explanations values analyzed identify risk factors thinking. Results When trained South 95% CI, XGBoost reported an area under receiver operating characteristic (AUROC) curve 90.06% (95% CI 89.97-90.16), displaying superior performance compared other models. For United States Norway, achieved AUROCs 83.09% 81.27%, respectively. Across all sets, consistently outperformed highest AUROC score, was selected as optimal model. In terms predictors thinking, feelings sadness despair most influential, accounting 57.4% impact, followed by stress status at 19.8%. age (5.7%), household income (4%), academic achievement (3.4%), sex (2.1%), others, which contributed less than 2% each. Conclusions integrating diverse 3 countries address suicide. The findings highlight important role emotional health indicators in predicting Specifically, identified significant predictors, stressful conditions age. These emphasize critical need early diagnosis prevention mental issues during adolescence.

Language: Английский

Citations

9
Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors DOI

Angela Michela De Stasi,

Javier Zorrilla de San Martín, Nina Nitzan Soto

et al.

Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 45(6), P. e2393232024 - e2393232024

Published: Feb. 5, 2025

The prefrontal cortex (PFC) plays a key role in high-level cognitive functions and emotional behaviors, PFC alterations correlate with different brain disorders including major depression anxiety. In mice, the first two postnatal weeks represent critical period of high sensitivity to environmental changes. this temporal window, serotonin (5-HT) levels regulate wiring cortical neurons. Early-life insults exposure selective reuptake inhibitor fluoxetine (FLX) affect development leading depressive anxiety-like phenotypes adult mice. However, mechanisms responsible for these dysfunctions remain obscure. We found that early FLX (PNFLX) results reduced overall firing high-frequency bursting putative pyramidal neurons (PNs) deep layers medial mice both sexes vivo. Ex vivo, patch-clamp recordings revealed PNFLX abolished distinct subpopulation deep-layer mPFC PNs, which transiently express transporter SERT during 2 weeks. SERT+ SERT− PNs exhibit morphofunctional properties. Genetic deletion 5-HT7Rs pharmacological 5-HT7R blockade partially rescued PNFLX-induced reduction PN vivo altered vitro. This indicates pivotal 5-HTR subtype mediating 5-HT-dependent maturation circuits are susceptible early-life insults. Overall, our suggest potential novel neurobiological mechanisms, underlying detrimental neurodevelopmental consequences induced by 5-HT levels.

Language: Английский

Citations

1
Frequent Low-Dose Δ9-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood DOI
Kyungmin Lee, Kwang‐Mook Jung, Yannick Fotio

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(11), P. 845 - 860

Published: May 10, 2022

Language: Английский

Citations

30
Functional dysconnectivity in youth depression: Systematic review, meta‐analysis, and network-based integration DOI Creative Commons
Nga Yan Tse, Aswin Ratheesh, Saampras Ganesan

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105394 - 105394

Published: Sept. 20, 2023

Youth depression has been associated with heterogenous patterns of aberrant brain connectivity. To make sense these divergent findings, we conducted a systematic review encompassing 19 resting-state fMRI seed-to-whole-brain studies (1400 participants, comprising 795 youths major and 605 matched healthy controls). We incorporated separate meta-analyses connectivity abnormalities across the levels most commonly seeded networks (default-mode limbic networks) and, based on recent additions to literature, an updated meta-analysis amygdala dysconnectivity in youth depression. Our findings indicated broad distributed at anatomical level, which could not be captured by conventional terms spatial convergence. However, were able parse complexity region-to-region considering constituent regions as components canonical networks. This integration revealed centred central executive, default mode, salience, networks, converging from adult literature suggesting similar neurobiological underpinnings

Language: Английский

Citations

22
From pupil to the brain: New insights for studying cortical plasticity through pupillometry DOI Creative Commons
Aurelia Viglione, Raffaele Mazziotti, Tommaso Pizzorusso

et al.

Frontiers in Neural Circuits, Journal Year: 2023, Volume and Issue: 17

Published: March 31, 2023

Pupil size variations have been associated with changes in brain activity patterns related specific cognitive factors, such as arousal, attention, and mental effort. The locus coeruleus (LC), a key hub the noradrenergic system of brain, is considered to be regulator control on pupil size, diameter corresponding release norepinephrine (NE). Advances eye-tracking technology open-source software facilitated accurate measurement various experimental settings, leading increased interest using pupillometry track nervous activation state potential biomarker for disorders. This review explores non-invasive fully translational tool studying cortical plasticity starting from recent literature suggesting that could promising technique estimating degree residual human subjects. Given NE known critical mediator includes data revealing importance LC-NE modulating size. Finally, we will provide quantitative complementary measure also pre-clinical studies.

Language: Английский

Citations

19
Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation DOI Creative Commons
Jastyn A. Pöpplau,

Timo Schwarze,

Мария Дорофейкова

et al.

Neuron, Journal Year: 2023, Volume and Issue: 112(3), P. 421 - 440.e7

Published: Nov. 17, 2023

Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to protracted timeline of development, which likely does not reach full maturity before end adolescence. However, underlying mechanisms that drive emergence and fine-tuning abilities adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored activity throughout postnatal development mice showed an initial increase was interrupted extensive microglia-mediated breakdown activity, followed rewiring elements achieve adult-like patterns synchrony. Interfering with these processes but adulthood, led a long-lasting microglia-induced disruption neuronal morphology decreased abilities. These results identified nonlinear reorganization circuits adolescence revealed its importance for adult network function processing.

Language: Английский

Citations

18