A Novel and Integrated Digitally Supported System of Care for Depression and Anxiety: Findings From an Open Trial (Preprint) DOI
Kate Wolitzky‐Taylor, Richard T. LeBeau, Inna Arnaudova

et al.

Published: March 1, 2023

BACKGROUND The global burden of anxiety and depression has created an urgent need for scalable approaches to increase access evidence-based mental health care. Screening Treatment Anxiety Depression (STAND) system care was developed meet this through the use internet-connected devices assessment provision treatment. STAND triages level (monitoring only, digital therapy with coaches, assisted by clinicians in training, clinical care) then continuously monitors symptoms adapt Triaging adaptation are based on symptom severity suicide risk scores obtained from computerized adaptive testing administered remotely. OBJECTIVE This article discusses how improves upon current paradigms, presents preliminary data feasibility, acceptability, effectiveness a sample US-based university students. METHODS students were recruited enrolled open trial Participants triaged initial derived test monitored over 40 weeks anxiety, depression, inform treatment evaluate effectiveness. RESULTS Nearly 5000 screened 516 received improved across all tiers (<i>P</i>&lt;.001 cases). Suicide highest tier (ie, care; <i>P</i>&lt;.001). Acceptability feasibility demonstrated. CONCLUSIONS is feasible acceptable model that can reach large numbers individuals. showed primary outcome measures. Current directions improve described.

Language: Английский

Recent Advances on Social Determinants of Mental Health: Looking Fast Forward DOI
Margarita Alegrı́a, Kiara Álvarez, Michelle Cheng

et al.

American Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 180(7), P. 473 - 482

Published: July 1, 2023

The fields of psychiatry and mental health are increasingly recognizing the importance social determinants (SDOH) their impact on outcomes. In this overview, authors discuss recent research, from past 5 years, advances made in SDOH work. frameworks theories have expanded to include more conditions, traumas associated with immigration psychosocial community strengths, that well-being. Research has consistently shown pervasive deleterious impacts inequitable conditions (e.g., food insecurity, housing instability) minoritized populations’ physical health. Social systems oppression racism, minoritization) also been confer higher risk for psychiatric disorders. COVID-19 pandemic illuminated More efforts years intervene through interventions at individual, community, policy levels, which promise improving outcomes marginalized populations. However, major gaps remain. Attention should be paid developing guiding incorporate equity antiracism when designing methodological approaches evaluating these interventions. addition, structural-level policy-level critical making long-lasting impactful toward equity.

Language: Английский

Citations

50
From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders DOI Creative Commons
Masaru Tanaka, László Vécsei

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 613 - 613

Published: March 8, 2024

Neuroscience, neurology, and psychiatry are rapidly evolving fields that aim to understand the complex mechanisms underlying brain function dysfunction, as well develop effective interventions for various neurological psychiatric disorders [...]

Language: Английский

Citations

19
Time to synergize mental health with brain health DOI
Agustín Ibáñez, Eduardo R. Zimmer

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(7), P. 441 - 443

Published: July 10, 2023

Language: Английский

Citations

38
Editorial: Towards a mechanistic understanding of depression, anxiety, and their comorbidity: perspectives from cognitive neuroscience DOI Creative Commons
Masaru Tanaka, Chong Chen

Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 15, 2023

EDITORIAL article Front. Behav. Neurosci., 15 August 2023Sec. Emotion Regulation and Processing Volume 17 - 2023 | https://doi.org/10.3389/fnbeh.2023.1268156

Language: Английский

Citations

34
From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders DOI Open Access
Masaru Tanaka, László Vécsei

Published: March 5, 2024

Delve into the dynamic realms of neuroscience, neurology, and psychiatry with this groundbreaking editorial, unveiling intricate mechanisms brain function dysfunction. Explore latest advancements in molecular biology, genetics, epigenetics, pharmacology, neuroimaging that are revolutionizing our understanding neurological psychiatric disorders. Uncover challenges gaps translating cutting-edge research practical clinical applications, aiming to enhance lives patients their families. Discover pivotal role neuroplasticity reshaping brain's adaptability throughout life, alongside promising potential non-invasive stimulation techniques like transcranial magnetic direct current stimulation. Embark on a journey innovation collaboration as researchers clinicians strive bridge gap between bench bedside, offering hope for improved diagnosis, prevention, treatment complex conditions. Join us exploration transformative ideas novel interventions hold key brighter future individuals society.

Language: Английский

Citations

16
Different components of cognitive-behavioral therapy affect specific cognitive mechanisms DOI Creative Commons
Agnes Norbury, Tobias U. Hauser, Stephen M. Fleming

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(13)

Published: March 27, 2024

Psychological therapies are among the most effective treatments for common mental health problems—however, we still know relatively little about how exactly they improve symptoms. Here, demonstrate power of combining theory with computational methods to parse effects different components cognitive-behavioral onto underlying mechanisms. Specifically, present data from a series randomized-controlled experiments testing brief behavioral and cognitive on processes, using well-validated measures associated models. A goal setting intervention, based activation therapy activities, reliably selectively reduced sensitivity effort when deciding act gain reward. By contrast, restructuring materials, tendency attribute negative everyday events self-related causes. The each intervention were specific these respective measures. Our approach provides basis beginning understand elements psychotherapy programs may work.

Language: Английский

Citations

15
Positive affect and reward processing in the treatment of depression, anxiety and trauma DOI
Michelle G. Craske,

Barnaby D. Dunn,

Alicia E. Meuret

et al.

Nature Reviews Psychology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Language: Английский

Citations

15
A Novel and Integrated Digitally Supported System of Care for Depression and Anxiety: Findings From an Open Trial DOI Creative Commons
Kate Wolitzky‐Taylor, Richard T. LeBeau, Inna Arnaudova

et al.

JMIR Mental Health, Journal Year: 2023, Volume and Issue: 10, P. e46200 - e46200

Published: May 26, 2023

The global burden of anxiety and depression has created an urgent need for scalable approaches to increase access evidence-based mental health care. Screening Treatment Anxiety Depression (STAND) system care was developed meet this through the use internet-connected devices assessment provision treatment. STAND triages level (monitoring only, digital therapy with coaches, assisted by clinicians in training, clinical care) then continuously monitors symptoms adapt Triaging adaptation are based on symptom severity suicide risk scores obtained from computerized adaptive testing administered remotely.This article discusses how improves upon current paradigms, presents preliminary data feasibility, acceptability, effectiveness a sample US-based university students.US-based students were recruited enrolled open trial Participants triaged initial derived test monitored over 40 weeks anxiety, depression, inform treatment evaluate effectiveness.Nearly 5000 screened 516 received improved across all tiers (P<.001 cases). Suicide highest tier (ie, care; P<.001). Acceptability feasibility demonstrated.STAND is feasible acceptable model that can reach large numbers individuals. showed primary outcome measures. Current directions improve described.

Language: Английский

Citations

16
Brain Iron Homeostasis and Mental Disorders DOI Creative Commons
Qiong Wu,

Qiuyang Ren,

Jingsi Meng

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1997 - 1997

Published: Nov. 13, 2023

Iron plays an essential role in various physiological processes. A disruption iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders has not received significant attention. Therefore, our understanding of metabolism context psychological diseases is incomplete. In this review, we aim discuss pathologies potential mechanisms that relate associated disorders. We propose hypothesis maintaining brain support neuronal functions by impacting key enzymatic activities during neurotransmission, redox balance, myelination. conclusion, review highlights importance investigating relationship trace element nutrition pathological process focusing on iron. This nutritional perspective offer valuable insights for clinical treatment

Language: Английский

Citations

15
Novel missense variants in brain morphogenic genes associated with depression and schizophrenia DOI Creative Commons
Maxim Karagyaur, A. L. Primak,

Kirill Bozov

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: April 18, 2024

Introduction Impaired function of brain morphogenic genes is considered one the predisposing factors for manifestation psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) major depressive disorder (MDD). Identification (genes neurotrophic guidance molecules among them) their deleterious genetic variants serves a key to diagnosis, prevention, possibly treatment disorders. In this study, we have examined prevalence genomic in individuals with SCZ MDD within Russian population. Methods We performed whole-exome sequencing 21 DNA samples: 11 from 10 MDD, followed by ARMS (Amplification-Refractory Mutation System) based screening detected single nucleotide (SNVs) larger groups: 102 SCZ, 79 those 103 healthy donors. Results Whole-exome has revealed 226 missense mutations (out 140 studied), some which occur patients disorders significantly more frequently than identified previously undescribed genes: CDH2 (rs1944294-T rs17445840-T), DCHS2 (rs11935573-G rs12500437-G/T) CDH23 (rs1227051-G/A), associated incidence For SNVs (rs6265-T, rs1944294-T, rs11935573-G, rs4760-G) sex-biased differences between SCZ/MDD donors was detected. Discussion However, functional significance still be confirmed cellular animal models. Once it fulfilled, these potential complement diagnostic toolbox assessing susceptibility mental The data obtained indirectly confirm importance adequate structure formation its correct functioning preservation health.

Language: Английский

Citations

5