Encyclopedia,
Journal Year:
2022,
Volume and Issue:
3(1), P. 15 - 27
Published: Dec. 26, 2022
The
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
infected
over
600
million
people
worldwide,
including
millions
of
pregnant
women.
While
newborns
exposed
to
other
viruses
in
utero
are
sometimes
at
high
risk
for
vertical
transmission,
a
substantial
body
literature
since
early
2020
demonstrated
that
transmission
SARS-CoV-2
from
mother
neonate
is
rare,
and
who
do
become
with
generally
have
favorable
outcomes.
In
this
review,
the
authors
evaluate
existing
on
its
potential
mechanisms
discuss
short-
long-term
health
outcomes
were
utero.
conclude
adverse
neonatal
infant/child
unlikely,
but
neonates
prenatal
maternal
infection
may
be
slightly
higher
preterm
birth,
possibly
related
increased
COVID-19
disease
women,
placental
changes,
or
timing.
Ultimately,
need
additional
longer-term
follow-up
data
population
highlighted.
JAMA Network Open,
Journal Year:
2023,
Volume and Issue:
6(3), P. e232969 - e232969
Published: March 14, 2023
Importance
Antenatal
stress
is
a
significant
risk
factor
for
poor
postpartum
mental
health.
The
association
of
pandemic-related
with
outcomes
among
mothers
and
infants
is,
however,
less
well
understood.
Objective
To
examine
the
antenatal
COVID-19–related
maternal
health
infant
outcomes.
Design,
Setting,
Participants
This
cohort
study
was
conducted
318
participants
in
COVID-19
Risks
Across
Lifespan
study,
which
took
place
Australia,
UK,
US.
Eligible
reported
being
pregnant
at
first
assessment
wave
between
May
5
September
30,
2020,
completed
follow-up
October
28,
2021,
April
24,
2022.
Main
Outcomes
Measures
assessed
Pandemic
Anxiety
Scale
(score
range,
0-4,
higher
scores
indicating
greater
stress).
8-item
Patient
Health
Questionnaire
0-3,
more
frequent
symptoms
depression)
used
to
measure
depression
each
time
point,
7-item
General
Disorder
scale
anxiety)
generalized
anxiety
point.
At
follow-up,
distress
10-item
Postpartum
Distress
Measure
distress),
(negative
positive
affectivity
orienting
behavior)
were
captured
Infant
Behavior
1-7,
that
exhibited
affect/behavior
frequently).
Results
included
women
(mean
[SD]
age,
32.0
[4.6]
years)
from
Australia
(88
[28%]),
US
(94
[30%]),
UK
(136
[43%]).
significantly
associated
(β
=
0.40
[95%
CI,
0.28-0.53]),
0.32
0.23-0.41]),
0.35
0.26-0.44]),
as
negative
0.45
0.14-0.76]).
findings
remained
consistent
across
range
sensitivity
analyses.
Conclusions
Relevance
this
suggest
targeting
stressors
period
may
improve
Pregnant
individuals
should
be
classified
vulnerable
group
during
pandemics
considered
public
priority,
not
only
terms
physical
but
also
Neuroscience & Biobehavioral Reviews,
Journal Year:
2024,
Volume and Issue:
162, P. 105723 - 105723
Published: May 16, 2024
The
COVID-19
pandemic,
with
its
far-reaching
influence
on
daily
life,
constituted
a
highly
stressful
experience
for
many
people
worldwide,
jeopardizing
individuals'
mental
health,
particularly
in
vulnerable
populations
such
as
pregnant
women.
While
growing
body
of
evidence
links
prenatal
maternal
stress
to
biological
and
developmental
alterations
offspring,
the
specific
impact
exposure
pandemic-related
(PRS)
infant
development
remains
unclear.
A
comprehensive
literature
search
was
performed
October
2023
according
PRISMA
guidelines,
which
yielded
total
28
records.
selected
papers
investigated
vast
range
outcomes
offspring
large
methodological
variations.
reviewed
studies
showed
mixed
results.
Either
direct
associations
between
PRS
during
pregnancy
temperament
socio-emotional
development,
or
indirect
links,
mediated
by
emerged
most
studies.
Furthermore,
associated
epigenetic
brain
although
were
limited
number.
Collectively,
findings
contribute
deeper
understanding
role
early
adverse
exposures
development.
American Journal of Human Biology,
Journal Year:
2025,
Volume and Issue:
37(5)
Published: May 1, 2025
ABSTRACT
Objectives
This
study
aimed
to
evaluate
whether
postpartum
maternal
stress
is
associated
with
infant
gastrointestinal
microbiome
composition
and
diversity,
this
relationship
may
be
mediated
by
caregiving
breastfeeding
behaviors
human
milk
(HMM)
composition.
Methods
Infant
fecal
samples
were
collected
from
51
exclusively
mother‐infant
dyads
in
the
Pacific
Northwest
between
1
6
months
postpartum.
sequencing
read
counts
>
773
(
n
=
48)
200
46)
analyzed
for
bacterial
alpha
diversity
(richness,
Shannon
diversity),
beta
(Bray–Curtis
dissimilarity),
genera
differential
abundances.
(IFM)
measures
tested
associations
mothers'
self‐reported
Parenting
Stress
Index
total
subscale
scores
regression
envfit
(beta
MaAsLin2
(genera
abundance)
models.
Potential
mediators
of
IFM
explored
(observed
time
breastfeeding;
maternal–infant
physical
contact
frequency;
HMM
abundance).
Results
Maternal
was
not
or
diversities.
Two
subscales
abundances
Erysipelotrichaceae
UCG‐003
(positively)
Eggerthella
(negatively)
feces.
two
(Role
Restriction,
Attachment)
positively
(q
attachment
0.07)
negatively
richness
0.08,
q
role
0.03).
Conclusions
Postpartum
consistently
during
exclusive
breastfeeding.
However,
suggesting
that
might
influence
other
developmental
pathways
infant.
Pediatric Research,
Journal Year:
2023,
Volume and Issue:
94(6), P. 2098 - 2104
Published: July 27, 2023
Abstract
Background
Maternal
stress
has
negative
consequences
on
infant
behavioral
development,
and
COVID-19
presented
uniquely
stressful
situations
to
mothers
of
infants
born
during
the
pandemic.
We
hypothesized
that
with
higher
levels
perceived
pandemic
would
report
regulatory
problems
including
crying
interrupted
sleep
patterns.
Methods
As
part
6
sites
a
longitudinal
study,
completed
Perceived
Stress
Scale,
Brief
Infant
Sleep
Questionnaire,
an
Crying
survey
at
(
n
=
433)
12
344)
months
age.
Results
stress,
which
remained
consistent
age,
was
significantly
positively
correlated
time
taken
settle
infants.
Although
maternal
not
uninterrupted
length,
put
correlated.
also
amount
fussiness
reported
months.
Conclusions
Mothers
who
problems,
specifically
Examining
how
varying
behaviors
relate
overall
developmental
status
over
is
important
next
step.
Impact
Women
giving
birth
Scale
old,
more
disruptive
patterns
in
their
old.
Sleeping
excessive
infancy
are
two
known
risk
factors
for
emotional
issues
later
childhood.
This
paper
one
first
studies
highlighting
associations
between
Frontiers in Child and Adolescent Psychiatry,
Journal Year:
2024,
Volume and Issue:
2
Published: Jan. 5, 2024
Background
and
aims
Close
autonomic
emotional
connections
with
others
help
infants
reach
maintain
homoeostasis.
In
recent
years,
infant
regulatory
problems
(RPs,
i.e.,
crying,
sleeping,
feeding
or
eating
problems)
have
surged.
This
study
has
two
aims:
(1)
Provide
proof-of-concept
that
dyadic
connection
between
parents
can
be
reliably
assessed
a
brief
screening,
irrespective
of
language
culture.
(2)
Assess
in
heterogeneous
pilot
sample
whether
the
persistence
RPs
during
infancy
is
negatively
associated
quality
connection.
Methods
30
children
aged
3–68
months
(47%
female)
their
(83%
mothers)
were
regular
neonatal
follow-up
visits
Germany.
Seven
(23%)
dyads
immigrants
whose
primary
was
not
German.
At
each
assessment,
paediatricians
asked
about
infant's
problems.
Dyadic
interactions
rated
by
multilingual
team
standardised
universal
Welch
Emotional
Connection
Screen
(uWECS)
on
four
dimensions
(attraction,
vocalisation,
facial
communication,
sensitivity/reciprocity).
Results
Aim
1:
An
international
raters
trained
remotely
to
rate
uWECS.
Reliability
α
>
.90
standard
achieved
mismatches
(i.e.,
all
scored
several
videos
languages
they
did
understand).
Intra-class
correlation
coefficients
(
ICCs
)
among
five
main
for
uWECS
ranged
from
.98–.99.
2:
Infants
n
=
15
longitudinally)
had
mean
RP
scores
1.20
(SD
1.26).
Dyads
7.06
2.09).
Linear
regression
analysis
showed
more
persistent
lower
[
β
-.53,
95%
CI
(-1.47,
-.18),
p
.017],
after
controlling
child
sex
gestational
age.
Conclusion
provides
mutual
socio-culturally
linguistically
samples
uWECS,
screening
easily
implemented
clinical
practice.
Pilot
data
suggests
are
Replication
these
findings
larger
warranted.
Future
studies
need
address
how
facilitate
successful
emotion
regulation
today's
future
generations.
Early Human Development,
Journal Year:
2024,
Volume and Issue:
189, P. 105931 - 105931
Published: Jan. 5, 2024
The
spread
of
the
COVID-19
virus
was
declared
a
pandemic
in
March
2020.
New
restrictions
such
as
'lockdowns'
and
'social
distancing'
created
challenges
for
individuals'
work-life
balance,
financial
situation,
family
life,
physical
mental
health.
global
population's
stress
levels
rose
response
to
these
changes,
leading
widespread
deterioration
One
group
particularly
affected
parents
infants
very
young
children.
Poor
parental
health
may
disrupt
parent-infant
bonding,
with
negative
consequences
infant
well-being
development.
Development and Psychopathology,
Journal Year:
2022,
Volume and Issue:
36(1), P. 161 - 169
Published: Nov. 8, 2022
Abstract
Researchers
have
begun
to
examine
the
psychological
toll
of
ongoing
global
COVID-19
pandemic.
Data
are
now
emerging
indicating
that
there
may
be
long-term
adverse
effects
pandemic
on
new
mothers
and
children
born
during
this
period.
In
a
longitudinal
study
maternal
mental
health
child
emotional
development
pandemic,
we
conducted
online
assessments
cohort
women
at
two
time
points:
when
they
were
pregnant
beginning
surge
in
United
States
(baseline,
N
=
725),
approximately
1
year
postpartum
(follow-up,
296),
examining
prenatal
postnatal
health,
pandemic-related
stress,
infant
temperament.
Pandemic-related
stress
baseline
was
associated
with
concurrent
depressive
symptoms
negative
affect
follow-up.
Baseline
follow-up
symptoms,
which
turn
also
affect.
pregnancy
enduring
These
findings
important
implications
for
our
understanding
who
utero
Journal of Clinical Medicine,
Journal Year:
2022,
Volume and Issue:
11(22), P. 6635 - 6635
Published: Nov. 9, 2022
Disruptions
in
perinatal
care
and
support
due
to
the
COVID-19
pandemic
was
an
unprecedented
but
significant
stressor
among
pregnant
women.
Various
neurostructural
differences
have
been
re-ported
fetuses
infants
born
during
compared
pre-pandemic
counterparts.
The
relationship
between
maternal
stress
related
disruptions
fetal
brain
is
yet
unexamined.Pregnant
participants
with
healthy
pregnancies
were
prospectively
recruited
2020-2022
greater
Los
Angeles
Area.
Participants
completed
multiple
self-report
assessments
for
experiences
of
disruptions,
perceived
stress,
coping
behaviors
underwent
MRI.
Maternal
exposures
correlated
quantitative
multimodal
MRI
measures
development
using
multivariate
models.Increased
perception
positively
normalized
brainstem
volume
(suggesting
accelerated
maturation).
In
contrast,
increased
reduced
global
temporal
functional
variance
connectivity).We
report
alterations
structure
activity
associated
suggesting
altered
programming.
Long
term
follow-up
studies
are
required
better
understand
sequalae
these
early
multi-modal
pandemic.