Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(15), P. 9081 - 9112
Published: June 20, 2024
Nanomaterial-microorganism
hybrid
systems
(NMHSs),
integrating
semiconductor
nanomaterials
with
microorganisms,
present
a
promising
platform
for
broadband
solar
energy
harvesting,
high-efficiency
carbon
reduction,
and
sustainable
chemical
production.
While
studies
underscore
its
potential
in
diverse
solar-to-chemical
conversions,
prevailing
NMHSs
grapple
suboptimal
conversion
efficiency.
Such
limitations
stem
predominantly
from
an
insufficient
systematic
exploration
of
the
mechanisms
dictating
flow.
This
review
provides
overview
notable
advancements
this
nascent
field,
particular
focus
on
discussion
three
pivotal
steps
flow:
capture,
cross-membrane
transport,
into
chemicals.
key
challenges
faced
each
stage
are
independently
identified
discussed,
viable
solutions
correspondingly
postulated.
In
view
interplay
affecting
overall
efficiency
conversion,
subsequent
discussions
thus
take
integrative
viewpoint
to
comprehend,
analyze
improve
flow
current
different
configurations,
highlighting
contemporary
techniques
that
can
be
employed
investigate
various
aspects
within
NMHSs.
Finally,
concluding
section
summarizes
opportunities
future
research,
providing
roadmap
continued
development
optimization
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: March 20, 2023
Metabolic
abnormalities
lead
to
the
dysfunction
of
metabolic
pathways
and
metabolite
accumulation
or
deficiency
which
is
well-recognized
hallmarks
diseases.
Metabolite
signatures
that
have
close
proximity
subject's
phenotypic
informative
dimension,
are
useful
for
predicting
diagnosis
prognosis
diseases
as
well
monitoring
treatments.
The
lack
early
biomarkers
could
poor
serious
outcomes.
Therefore,
noninvasive
methods
with
high
specificity
selectivity
desperately
needed.
Small
molecule
metabolites-based
metabolomics
has
become
a
specialized
tool
biomarker
pathway
analysis,
revealing
possible
mechanisms
human
various
deciphering
therapeutic
potentials.
It
help
identify
functional
related
variation
delineate
biochemical
changes
indicators
pathological
damage
prior
disease
development.
Recently,
scientists
established
large
number
profiles
reveal
underlying
networks
target
exploration
in
biomedicine.
This
review
summarized
analysis
on
potential
value
small-molecule
candidate
metabolites
clinical
events,
may
better
diagnosis,
prognosis,
drug
screening
treatment.
We
also
discuss
challenges
need
be
addressed
fuel
next
wave
breakthroughs.
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(4), P. 2349 - 2422
Published: April 6, 2023
Mitochondria
are
well
known
as
organelles
responsible
for
the
maintenance
of
cellular
bioenergetics
through
production
ATP.
Although
oxidative
phosphorylation
may
be
their
most
important
function,
mitochondria
also
integral
synthesis
metabolic
precursors,
calcium
regulation,
reactive
oxygen
species,
immune
signaling,
and
apoptosis.
Considering
breadth
responsibilities,
fundamental
metabolism
homeostasis.
Appreciating
this
significance,
translational
medicine
has
begun
to
investigate
how
mitochondrial
dysfunction
can
represent
a
harbinger
disease.
In
review,
we
provide
detailed
overview
metabolism,
bioenergetics,
dynamics,
autophagy,
damage-associated
molecular
patterns,
mitochondria-mediated
cell
death
pathways,
at
any
these
levels
is
associated
with
disease
pathogenesis.
Mitochondria-dependent
pathways
thereby
an
attractive
therapeutic
target
ameliorating
human
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(3), P. 3459 - 3636
Published: Jan. 7, 2022
Synthetic
molecular
probes,
chemosensors,
and
nanosensors
used
in
combination
with
innovative
assay
protocols
hold
great
potential
for
the
development
of
robust,
low-cost,
fast-responding
sensors
that
are
applicable
biofluids
(urine,
blood,
saliva).
Particularly,
metabolites,
neurotransmitters,
drugs,
inorganic
ions
is
highly
desirable
due
to
a
lack
suitable
biosensors.
In
addition,
monitoring
analysis
metabolic
signaling
networks
cells
organisms
by
optical
probes
chemosensors
becoming
increasingly
important
biology
medicine.
Thus,
new
perspectives
personalized
diagnostics,
theranostics,
biochemical/medical
research
will
be
unlocked
when
standing
limitations
artificial
binders
receptors
overcome.
this
review,
we
survey
synthetic
sensing
systems
have
promising
(future)
application
detection
small
molecules,
cations,
anions
aqueous
media
biofluids.
Special
attention
was
given
provide
readily
measurable
signal
through
dynamic
covalent
chemistry,
supramolecular
host-guest
interactions,
or
nanoparticles
featuring
plasmonic
effects.
This
review
shall
also
enable
reader
evaluate
current
performance
terms
sensitivity
selectivity
respect
practical
requirement,
thereby
inspiring
ideas
further
advanced
systems.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 7898 - 7898
Published: April 26, 2023
Metabolic
syndrome
is
a
cluster
of
conditions
associated
with
the
risk
diabetes
mellitus
type
2
and
cardiovascular
diseases
(CVDs).
closely
related
to
obesity.
Increased
adiposity
promotes
inflammation
oxidative
stress,
which
are
precursors
various
complications
involving
metabolic
components,
namely
insulin
resistance,
hypertension,
hyperlipidemia.
An
increasing
number
studies
confirm
importance
stress
chronic
in
etiology
syndrome.
However,
few
have
reviewed
mechanisms
underlying
role
contributing
In
this
review,
we
highlight
by
reactive
oxygen
species
(ROS)
increase
mitochondrial
dysfunction,
protein
damage,
lipid
peroxidation,
impair
antioxidant
function
Biomarkers
can
be
used
disease
diagnosis
evaluation
severity.
Molecular Metabolism,
Journal Year:
2021,
Volume and Issue:
49, P. 101195 - 101195
Published: Feb. 18, 2021
Nicotinamide
adenine
dinucleotide
(NAD+),
a
critical
coenzyme
present
in
every
living
cell,
is
involved
myriad
of
metabolic
processes
associated
with
cellular
bioenergetics.
For
this
reason,
NAD+
often
studied
the
context
aging,
cancer,
and
neurodegenerative
disorders.
Cellular
depletion
compromised
adaptive
stress
responses,
impaired
neuronal
plasticity,
DNA
repair,
senescence.
Increasing
evidence
has
shown
efficacy
boosting
levels
using
precursors
various
diseases.
This
review
provides
comprehensive
understanding
into
role
aging
other
pathologies
discusses
potential
therapeutic
targets.
An
alteration
NAD+/NADH
ratio
or
pool
size
can
lead
to
derailment
biological
system
contribute
disorders,
tumorigenesis.
Due
varied
distribution
different
locations
within
cells,
direct
NAD+-dependent
humans
remains
unestablished.
In
regard,
longitudinal
studies
are
needed
quantify
its
related
metabolites.
Future
research
should
focus
on
measuring
fluxes
through
pathways
synthesis
degradation.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 23
Published: Oct. 19, 2022
Reactive
oxygen
species
(ROS)
are
bioproducts
of
cellular
metabolism.
There
is
a
range
molecules
with
oxidizing
properties
known
as
ROS.
Despite
those
being
implied
negatively
in
aging
and
numerous
diseases,
their
key
role
signaling
evident.
ROS
control
several
biological
processes
such
inflammation,
proliferation,
cell
death.
The
redox
underlying
these
events
one
characteristic
the
new
generation
scientists
aimed
at
defining
environment.
potential,
which
includes
balance
sources
antioxidant
system,
implies
an
important
target
for
understanding
cells’
fate
derived
from
signaling.
In
this
review,
we
summarized
chemical,
balance,
signaling,
implications
aging.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: March 1, 2021
Cancer
is
a
disease
which
frequently
has
poor
prognosis.
Although
multiple
therapeutic
strategies
have
been
developed
for
various
cancers,
including
chemotherapy,
radiotherapy,
and
immunotherapy,
resistance
to
these
treatments
impedes
the
clinical
outcomes.
Besides
active
driven
by
genetic
epigenetic
alterations
in
tumor
cells,
microenvironment
(TME)
also
reported
be
crucial
regulator
tumorigenesis,
progression,
resistance.
Here,
we
propose
that
adaptive
mechanisms
of
are
closely
connected
with
TME
rather
than
depending
on
non-cell-autonomous
changes
response
treatment.
comprehensive
understanding
need
further
investigation
fully
elucidate
resistance,
many
targeting
successful.
In
this
review,
report
recent
advances
concerning
molecular
events
important
factors
involved
TME,
particularly
focusing
contributions
provide
insights
into
potential
methods
or
translational
medicine
overcome
therapy
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(2), P. 774 - 774
Published: Jan. 11, 2022
Alcoholic
liver
disease
(ALD)
is
characterized
by
the
injury,
inflammation,
and
scarring
in
owing
to
excessive
alcohol
consumption.
Currently,
ALD
a
leading
cause
for
transplantation.
Therefore,
extensive
studies
(in
vitro,
experimental
models
humans)
are
needed
elucidate
pathological
features
pathogenic
mechanisms
underlying
ALD.
Notably,
oxidative
changes
have
been
recognized
as
signature
trait
of
Progression
linked
generation
highly
reactive
free
radicals
reactions
involving
ethanol
its
metabolites.
Furthermore,
hepatic
stress
promotes
tissue
injury
and,
turn,
stimulates
inflammatory
responses
liver,
forming
loop
that
progression
Accordingly,
accumulating
further
knowledge
on
relationship
between
inflammation
may
help
establish
viable
therapeutic
approach
treating