Oxidative stress: Roles in skeletal muscle atrophy

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 214, P. 115664 - 115664

Published: June 16, 2023

Language: Английский

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

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New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2698 - 2698

Published: Feb. 26, 2024

Oxidative stress (OS) and inflammation are two important well-studied pathological hallmarks of neurodegenerative diseases (NDDs). Due to elevated oxygen consumption, the high presence easily oxidizable polyunsaturated fatty acids weak antioxidant defenses, brain is particularly vulnerable oxidative injury. Uncertainty exists over whether these deficits contribute development NDDs or solely a consequence neuronal degeneration. Furthermore, linked, it known that OS can affect inflammatory response. In this review, we will overview last findings about pathways in principal NDDs. Moreover, focus more depth on amyotrophic lateral sclerosis (ALS) understand how anti-inflammatory antioxidants drugs have been used for treatment still incurable motor neuron (MN) disease. Finally, analyze past actual clinical trials future perspectives study mechanisms.

Language: Английский

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Catalyzing innovation: Exploring iron oxide nanoparticles - Origins, advancements, and future application horizons

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 507, P. 215750 - 215750

Published: Feb. 29, 2024

Language: Английский

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Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

Clinical Science, Journal Year: 2024, Volume and Issue: 138(13), P. 817 - 850

Published: June 26, 2024

Abstract Optimal vascular structure and function are essential for maintaining the physiological functions of cardiovascular system. Vascular remodelling involves changes in vessel structure, including its size, shape, cellular molecular composition. These result from multiple risk factors may be compensatory adaptations to sustain blood function. They occur diverse pathologies, hypertension heart failure atherosclerosis. Dynamic endothelium, fibroblasts, smooth muscle cells, pericytes or other wall cells underlie remodelling. In addition, immune macrophages lymphocytes, infiltrate vessels initiate inflammatory signalling. contribute a dynamic interplay between cell proliferation, apoptosis, migration, inflammation, extracellular matrix reorganisation, all critical mechanisms Molecular pathways underlying these processes include growth (e.g., endothelial factor platelet-derived factor), cytokines interleukin-1β tumour necrosis factor-α), reactive oxygen species, signalling pathways, such as Rho/ROCK, MAPK, TGF-β/Smad, related nitric oxide superoxide biology. MicroRNAs long noncoding RNAs crucial epigenetic regulators gene expression We evaluate potential therapeutic targeting clinical translational perspective. summary, remodelling, coordinated modification function, is disease pathology.

Language: Английский

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Redox changes and cellular senescence in Alzheimer's disease

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103048 - 103048

Published: Jan. 17, 2024

The redox process and cellular senescence are involved in a range of essential physiological functions. However, they also implicated pathological processes underlying age-related neurodegenerative disorders, including Alzheimer's disease (AD). Elevated levels reactive oxygen species (ROS) generated as result abnormal accumulation beta-amyloid peptide (Aβ), tau protein, heme dyshomeostasis is further aggravated by mitochondria dysfunction endoplasmic reticulum (ER) stress. Excessive ROS damages vital components such proteins, DNA lipids. Such damage eventually leads to impaired neuronal function cell death. Heightened oxidative stress can induce via activation the senescence-associated secretory phenotype exacerbate inflammation tissue dysfunction. In this review, we focus on how changes system contribute AD affected perturbations metabolism mitochondrial function. While potential therapeutic strategies targeting have received some attention, more research necessary bring them into clinical application.

Language: Английский

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Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: March 6, 2024

Abstract The quest for effective and reliable methods of delivering medications, with the aim improving delivery therapeutic agent to intended location, has presented a demanding yet captivating field in biomedical research. concept smart drug systems is an evolving approach, serving as model directing drugs specific targets or sites. These have been developed specifically target regulate administration substances diverse array chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel rheumatoid arthritis, different cancers. Nevertheless, numerous comprehensive clinical trials are still required ascertain both immediate enduring impacts such nanosystems on human subjects. This review delves into benefits vehicles, aiming enhance comprehension their applicability addressing present medical requirements. Additionally, it touches upon current applications these stimuli‐reactive biomedicine outlines future development prospects.

Language: Английский

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Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 504 - 504

Published: April 23, 2024

Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.

Language: Английский

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Phytochemicals and Biological Activities of Walnut Septum: A Systematic Review

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 604 - 604

Published: March 1, 2023

In the last few decades, scientific evidence has stressed importance of plants in prevention and/or supportive treatment a plethora diseases, many them chronic, age-associated disorders. Juglans regia L. is traditional plant that been integrated into medicine since ancient times. Due to presence biologically active compounds, walnut was used various maladies. Recently, investigations have focused on by-products and waste products, with research their valuable constituents properties. Among these secondary septum analyzed several studies, its phytochemical profile described, some biological activities examined. However, compared other by-products, no comprehensive review gather all pertinent knowledge found literature. Therefore, aim this study critically assess information furnished by peer-reviewed articles regarding chemical composition related activities, including antioxidant anti-inflammatory effects, antimicrobial properties, antidiabetic anti-tumor anti-aging potential. conclusion, as preclinical studies showed metabolites were responsible for wide range preventive therapeutic uses, further should confirm beneficial outcomes clinical trials.

Language: Английский

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Reactive oxidant species induced by antifungal drugs: identity, origins, functions, and connection to stress-induced cell death

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Oct. 12, 2023

Reactive oxidant species (ROS) are unstable, highly reactive molecules that produced by cells either as byproducts of metabolism or synthesized specialized enzymes. ROS can be detrimental, e.g., damaging cellular macromolecules, beneficial, participating in signaling. An increasing body evidence shows various fungal species, including both yeasts and molds, increase production upon exposure to the antifungal drugs currently used clinic: azoles, polyenes, echinocandins. However, implications these findings still largely unclear due gaps knowledge regarding chemical nature, molecular origins, functional consequences ROS. Because detection has relied on fluorescent probes lack specificity, nature is not known, it may vary depending specific fungus-drug combination. In several instances, origin drug-induced been identified mitochondria, but further experiments necessary strengthen this conclusion investigate other potential sources, such ER, peroxisomes, ROS-producing With respect function ROS, studies have shown they contribute drugs’ fungicidal activities part programmed cell death (PCD). whether “pro-death” a primary consequence mechanism action secondary PCD remains unclear. Finally, recent raised possibility induction serve an adaptive role, promoting drug tolerance evolution resistance. Filling will reveal new aspect biology identify ways potentiate activity prevent

Language: Английский

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