Modulation of cellular processes by histone and non-histone protein acetylation

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(5), P. 329 - 349

Published: Jan. 18, 2022

Language: Английский

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Small molecule metabolites: discovery of biomarkers and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 20, 2023

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks diseases. Metabolite signatures that have close proximity subject's phenotypic informative dimension, are useful for predicting diagnosis prognosis diseases as well monitoring treatments. The lack early biomarkers could poor serious outcomes. Therefore, noninvasive methods with high specificity selectivity desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool biomarker pathway analysis, revealing possible mechanisms human various deciphering therapeutic potentials. It help identify functional related variation delineate biochemical changes indicators pathological damage prior disease development. Recently, scientists established large number profiles reveal underlying networks target exploration in biomedicine. This review summarized analysis on potential value small-molecule candidate metabolites clinical events, may better diagnosis, prognosis, drug screening treatment. We also discuss challenges need be addressed fuel next wave breakthroughs.

Language: Английский

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Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(3), P. 3459 - 3636

Published: Jan. 7, 2022

Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, fast-responding sensors that are applicable biofluids (urine, blood, saliva). Particularly, metabolites, neurotransmitters, drugs, inorganic ions is highly desirable due to a lack suitable biosensors. In addition, monitoring analysis metabolic signaling networks cells organisms by optical probes chemosensors becoming increasingly important biology medicine. Thus, new perspectives personalized diagnostics, theranostics, biochemical/medical research will be unlocked when standing limitations artificial binders receptors overcome. this review, we survey synthetic sensing systems have promising (future) application detection small molecules, cations, anions aqueous media biofluids. Special attention was given provide readily measurable signal through dynamic covalent chemistry, supramolecular host-guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable reader evaluate current performance terms sensitivity selectivity respect practical requirement, thereby inspiring ideas further advanced systems.

Language: Английский

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Mitochondria in health, disease, and aging

Physiological Reviews, Journal Year: 2023, Volume and Issue: 103(4), P. 2349 - 2422

Published: April 6, 2023

Mitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through production ATP. Although oxidative phosphorylation may be their most important function, mitochondria also integral synthesis metabolic precursors, calcium regulation, reactive oxygen species, immune signaling, and apoptosis. Considering breadth responsibilities, fundamental metabolism homeostasis. Appreciating this significance, translational medicine has begun to investigate how mitochondrial dysfunction can represent a harbinger disease. In review, we provide detailed overview metabolism, bioenergetics, dynamics, autophagy, damage-associated molecular patterns, mitochondria-mediated cell death pathways, at any these levels is associated with disease pathogenesis. Mitochondria-dependent pathways thereby an attractive therapeutic target ameliorating human

Language: Английский

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Mechanisms of Oxidative Stress in Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7898 - 7898

Published: April 26, 2023

Metabolic syndrome is a cluster of conditions associated with the risk diabetes mellitus type 2 and cardiovascular diseases (CVDs). closely related to obesity. Increased adiposity promotes inflammation oxidative stress, which are precursors various complications involving metabolic components, namely insulin resistance, hypertension, hyperlipidemia. An increasing number studies confirm importance stress chronic in etiology syndrome. However, few have reviewed mechanisms underlying role contributing In this review, we highlight by reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, impair antioxidant function Biomarkers can be used disease diagnosis evaluation severity.

Language: Английский

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Role of NAD+ in regulating cellular and metabolic signaling pathways

Molecular Metabolism, Journal Year: 2021, Volume and Issue: 49, P. 101195 - 101195

Published: Feb. 18, 2021

Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ often studied the context aging, cancer, and neurodegenerative disorders. Cellular depletion compromised adaptive stress responses, impaired neuronal plasticity, DNA repair, senescence. Increasing evidence has shown efficacy boosting levels using precursors various diseases. This review provides comprehensive understanding into role aging other pathologies discusses potential therapeutic targets. An alteration NAD+/NADH ratio or pool size can lead to derailment biological system contribute disorders, tumorigenesis. Due varied distribution different locations within cells, direct NAD+-dependent humans remains unestablished. In regard, longitudinal studies are needed quantify its related metabolites. Future research should focus on measuring fluxes through pathways synthesis degradation.

Language: Английский

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Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: March 1, 2021

Cancer is a disease which frequently has poor prognosis. Although multiple therapeutic strategies have been developed for various cancers, including chemotherapy, radiotherapy, and immunotherapy, resistance to these treatments impedes the clinical outcomes. Besides active driven by genetic epigenetic alterations in tumor cells, microenvironment (TME) also reported be crucial regulator tumorigenesis, progression, resistance. Here, we propose that adaptive mechanisms of are closely connected with TME rather than depending on non-cell-autonomous changes response treatment. comprehensive understanding need further investigation fully elucidate resistance, many targeting successful. In this review, report recent advances concerning molecular events important factors involved TME, particularly focusing contributions provide insights into potential methods or translational medicine overcome therapy

Language: Английский

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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Oct. 19, 2022

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.

Language: Английский

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Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 774 - 774

Published: Jan. 11, 2022

Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in owing to excessive alcohol consumption. Currently, ALD a leading cause for transplantation. Therefore, extensive studies (in vitro, experimental models humans) are needed elucidate pathological features pathogenic mechanisms underlying ALD. Notably, oxidative changes have been recognized as signature trait of Progression linked generation highly reactive free radicals reactions involving ethanol its metabolites. Furthermore, hepatic stress promotes tissue injury and, turn, stimulates inflammatory responses liver, forming loop that progression Accordingly, accumulating further knowledge on relationship between inflammation may help establish viable therapeutic approach treating

Language: Английский

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iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(2), P. 189 - 208

Published: Feb. 1, 2022

Language: Английский

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