Cancer Biomarkers, Journal Year: 2023, Volume and Issue: 39(4), P. 361 - 370
Published: Dec. 29, 2023
Cms1 ribosomal small subunit homolog (CMSS1) is an RNA-binding protein that may play important role in tumorigenesis and development.
Language: Английский
Trends in Genetics, Journal Year: 2022, Volume and Issue: 39(1), P. 74 - 88
Published: Nov. 12, 2022
Cancer was initially considered to be an exclusively genetic disease, but interplay of dysregulated and epigenetic mechanisms is now known contribute the cancer phenotype. More recently, chemical modifications RNA molecules - so-called epitranscriptome have been found regulate various aspects function homeostasis. Specific enzymes, as RNA-modifying proteins (RMPs), are responsible for depositing, removing, reading in RNA. Intensive investigations epitranscriptomic field recent years, conjunction with great technological advances, revealed critical role regulating numerous cellular pathways. Furthermore, growing evidence has that modification machinery often altered human cancers, highlighting enormous potential RMPs pharmacological targets or diagnostic markers.
Language: Английский
Citations
80
Pharmacological Research, Journal Year: 2023, Volume and Issue: 194, P. 106822 - 106822
Published: June 17, 2023
Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year survival rate less than 10%, even in developed countries such as USA. The genomic profile alterations and dysregulated biological mechanisms commonly occur PC. Macroautophagy/autophagy cell death process that maintained at basal level physiological conditions, whereas its often changes during tumorigenesis. function of autophagy human cancers dual can be oncogenic onco-suppressor. Autophagy potent controller tumorigenesis supportive PC escalates growth cells suppression mediate death. also determines metastasis cells, it control EMT affecting migration. Moreover, starvation hypoxia stimulate glycolysis, glycolysis induction mediated by enhancing Furthermore, protective stimulates drug resistance gemcitabine inhibition enhance radiosensitivity. degrade MHC-I to immune evasion regulates polarization macrophages tumor microenvironment. Modulation activity provided silibinin, ursolic acid, chrysin huaier treatment Non-coding RNAs are controllers improve therapy response patients. mitophagy shows dysregulation PC, proliferation cells. Therefore, bioinformatics analysis demonstrates autophagy-related proteins genes biomarkers.
Language: Английский
Citations
65
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(2), P. 52 - 52
Published: Feb. 4, 2024
Primary liver cancer is one of the most common malignant tumors with high mortality and increasing incidence worldwide. Currently, chemotherapy an important comprehensive treatment for moderate or advanced cancer. Despite effective therapeutic effects initially achieved by chemotherapy, phenotypic molecular heterogeneity cells facilitates resistance to conventional targeted therapy even leads multidrug (MDR), which major obstacles clinical chemotherapy. Drug exhibits multiple complex mechanisms antagonize under pharmacological pressure, including overexpression drug efflux transporters, downstream adaptive response (such as apoptosis, autophagy, endoplasmic reticulum stress), dysfunction DNA damage repair (DDR), epigenetic modification, tumor microenvironment (TME) well extracellular matrix (ECM). In this paper, we summarize recent research progress intervention strategies in hepatocellular carcinoma (HCC), will provide a promising strategy overcoming MDR
Language: Английский
Citations
11
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111876 - 111876
Published: March 16, 2024
Language: Английский
Citations
9
Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155767 - 155767
Published: May 24, 2024
Language: Английский
Citations
8
Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216738 - 216738
Published: Feb. 23, 2024
Language: Английский
Citations
7
Environmental Research, Journal Year: 2023, Volume and Issue: 240, P. 117443 - 117443
Published: Oct. 18, 2023
Language: Английский
Citations
15
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: June 26, 2023
Abstract N 6 -methyladenosine (m A), one of the most common RNA methylation modifications, has emerged in recent years as a new layer regulatory mechanism controlling gene expression eukaryotes. As reversible epigenetic modification, m A not only occurs on mRNAs but also Long non-coding RNAs (LncRNAs). we all known, despite LncRNAs cannot encode proteins, they affect proteins by interacting with or miRNAs, thus playing important roles occurrence and development variety tumors. Up to now, it been widely accepted that modification affects fate corresponding LncRNAs. Interestingly, levels functions modifications are mediated through affecting methyltransferases (METTL3, METTL14, WTAP, METTL16, etc.), demethylases (FTO, ALKBH5) methyl-binding (YTHDFs, YTHDCs, IGF2BPs, HNRNPs, which collectively referred “m regulators”. In this review, summarized mutual regulation mechanisms between cancer progression, metastasis, invasion drug resistance. detail, focus specific is demethylases, involves LncRNA first part. And section two intensively displays mediation via changing proteins. At last part, described interaction effects during various tumor development.
Language: Английский
Citations
14
Cancers, Journal Year: 2023, Volume and Issue: 15(11), P. 3053 - 3053
Published: June 4, 2023
Cancer is a grave and persistent illness, with the rates of both its occurrence death toll increasing at an alarming pace. N6-methyladenosine (m6A), most prevalent mRNA modification in eukaryotic organisms, catalyzed by methyltransferases has significant impact on various aspects cancer progression. WT1-associated protein (WTAP) crucial component m6A methyltransferase complex, catalyzing methylation RNA. It been demonstrated to participate numerous cellular pathophysiological processes, including X chromosome inactivation, cell proliferation, cycle regulation, alternative splicing. A better understanding role WTAP may render it reliable factor for early diagnosis prognosis, as well key therapeutic target treatment. found that closely related tumor metabolic autophagy, immunity, ferroptosis, epithelial mesenchymal transformation (EMT), drug resistance. In this review, we will focus latest advances biological functions cancer, explore prospects application clinical therapy.
Language: Английский
Citations
13
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 195, P. 104271 - 104271
Published: Jan. 23, 2024
RNA-binding proteins (RBPs) refer to a class of that participate in alternative splicing, RNA stability, polyadenylation, localization and translation RNAs, thus regulating gene expression post-transcriptional manner. Dysregulation RNA-RBP interaction contributes various diseases, including cancer. In breast cancer, disorders RBP function influence the biological characteristics tumor cells. Targeting RBPs has fostered development innovative therapies for However, RBP-related mechanisms cancer are not completely clear. this review, we summarize regulatory their signaling crosstalk Specifically, emphasize potential certain as prognostic factors due effects on proliferation, invasion, apoptosis, therapy resistance Most importantly, present comprehensive overview latest therapeutic strategies novel targets have proven be useful treatment
Language: Английский
Citations
4