Programmed cell death and lipid metabolism of macrophages in NAFLD DOI Creative Commons
Zhun Xiao, Minghao Liu,

Fangming Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 18, 2023

Non-alcoholic fatty liver disease (NAFLD) has now become the leading chronic worldwide with lifestyle changes. This may lead to NAFLD becoming cause of end-stage in future. To date, there are still no effective therapeutic drugs for NAFLD. An in-depth exploration pathogenesis can help provide a basis new agents or strategies. As most important immune cells liver, macrophages play an role occurrence and development inflammation expected targets treatment. Programmed cell death (PCD) plays regulatory phenotypic transformation, is also certain connection between different types PCD. However, how PCD regulates macrophage polarization not been systematically elucidated. Based on lipid metabolic reprogramming polarization, alter phenotype by regulating metabolism. We reviewed effects changes their metabolism, as well relationship metabolism macrophages. Furthermore, interactions potential targeting explored.

Language: Английский

A researcher’s guide to preclinical mouse NASH models DOI
Suchira Gallage, Jose Efren Barragan Avila, Pierluigi Ramadori

et al.

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(12), P. 1632 - 1649

Published: Dec. 20, 2022

Language: Английский

Citations

111
Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health DOI Creative Commons
Zhijie Wan,

Jianheng Zheng,

Zhigang Zhu

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 13, 2022

Vitamin B consists of a group water-soluble micronutrients that are mainly derived from the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As an integrated part human health, gut microbiota could produce, consume, and even compete for vitamin with host. The interplay between host might be crucial factor affecting absorbing processes B. On other hand, supplementation or deficiency impact growth specific bacteria, resulting changes composition function microbiota. Together, systemically contribute to health. In this review, we summarized interactions tried reveal underlying mechanism so can have better understanding its role

Language: Английский

Citations

99
The role of CXCL family members in different diseases DOI Creative Commons
Chenjia Zhou, Ying Gao,

Peilun Ding

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 1, 2023

Chemokines are a large family mediating lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member this family, CXC subfamily possesses the same ability. chemokines can recruit migrate different categories immune cells, regulate tumor's pathological like proliferation, invasion metastasis, activate angiogenesis, etc. Due to these characteristics, CXCL is extensively closely associated with tumors inflammatory diseases. studies becoming more intensive, CXCLs' concrete roles better described, therapeutic applications biomarkers targets also deeply explained. In review, role members in various diseases summarized.

Language: Английский

Citations

96
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases DOI Creative Commons
Qian Lu, Yanli Zhu, Chao Deng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 1, 2024

Abstract Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, inflammation. Accumulating evidence has shown that implicated in diseases, such as cancers, cardiac diseases cardiovascular neurological disorders, kidney motor system metabolic disorders. Examining the upstream modulators co-activated partners identifying critical biological events modulated by downstream effectors contribute to presentation elaborate network PGC-1s. Furthermore, discussing correlation between well summarizing therapy targeting helps make individualized precise intervention methods. In this review, we summarize basic knowledge regarding molecular regulatory network, discuss physio-pathological roles human review application PGC-1s, diagnostic prognostic value several therapies pre-clinical studies, suggest directions for future investigations. This presents immense potential treatment hopefully facilitates promotion new therapeutic targets.

Language: Английский

Citations

81
Gut microbiota modulation in patients with non-alcoholic fatty liver disease: Effects of current treatments and future strategies DOI Creative Commons

Marta Maestri,

Francesco Santopaolo, Maurizio Pompili

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 16, 2023

Non-alcoholic fatty liver disease (NAFLD) is frequently associated with metabolic disorders, being highly prevalent in obese and diabetic patients. Many concomitant factors that promote systemic inflammation are involved NAFLD pathogenesis, a growing body of evidence highlighting the key role gut microbiota. Indeed, gut-liver axis has strong impact promotion progression wide spectrum its manifestations, claiming efforts to find effective strategies for microbiota modulation. Diet among most powerful tools; Western diet negatively affects intestinal permeability composition function, selecting pathobionts, whereas Mediterranean fosters health-promoting bacteria, favorable on lipid glucose metabolism inflammation. Antibiotics probiotics have been used improve features, mixed results. More interestingly, medications treat NAFLD-associated comorbidities may also modulate Drugs treatment type 2 diabetes mellitus (T2DM), such as metformin, glucagon-like peptide-1 (GLP-1) agonists, sodium-glucose cotransporter (SGLT) inhibitors, not only regulation homeostasis, but reduction fat content inflammation, they shift towards healthy phenotype. Even bariatric surgery significantly changes microbiota, mostly due modification gastrointestinal anatomy, parallel improvement histological features NAFLD. Other options promising effects reprogramming axis, fecal microbial transplantation (FMT) next-generation deserve further investigation future inclusion therapeutic armamentarium

Language: Английский

Citations

47
Neutrophil extracellular traps in homeostasis and disease DOI Creative Commons

Han Wang,

Susan J. Kim,

Lei Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

34
Liver diseases: epidemiology, causes, trends and predictions DOI Creative Commons

Can Gan,

Yuan Yuan, Haiyuan Shen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 4, 2025

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.

Language: Английский

Citations

6
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism DOI
Jie Jiang,

Yuqing Gao,

Jiang Wang

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

3
Cigarette Smoke Contributes to the Progression of MASLD: From the Molecular Mechanisms to Therapy DOI Creative Commons
Jihao Xu, Yifan Li,

Zhaolan Feng

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 221 - 221

Published: Feb. 4, 2025

Cigarette smoke (CS), an intricate blend comprising over 4000 compounds, induces abnormal cellular reactions that harm multiple tissues. Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic (CLD), encompassing non-alcoholic (NAFL), steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Recently, the term NAFLD has been changed to metabolic dysfunction-associated steatotic (MASLD), NASH renamed (MASH). A multitude of experiments have confirmed association between CS incidence progression MASLD. However, specific signaling pathways involved need be updated with new scientific discoveries. exposure can disrupt lipid metabolism, induce inflammation apoptosis, stimulate fibrosis through promote Currently, there no officially approved efficacious pharmaceutical intervention in clinical practice. Therefore, lifestyle modifications emerged as primary therapeutic approach for managing Smoking cessation application series natural ingredients shown ameliorate pathological changes induced by CS, potentially serving effective decelerating MASLD development. This article aims elucidate which smoking promotes MASLD, while summarizing reversal factors identified recent studies, thereby offering novel insights future research on treatment

Language: Английский

Citations

2
Major roles of kupffer cells and macrophages in NAFLD development DOI Creative Commons

Soo-Jeung Park,

Josefina Garcia Diaz,

Eugene Um

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 19, 2023

Non-alcoholic fatty liver disease (NAFLD) is an important public health problem with growing numbers of NAFLD patients worldwide. Pathological conditions are different in each stage due to various factors. Preclinical and clinical studies provide evidence for a crucial role immune cells progression. Liver-resident macrophages, kupffer (KCs), monocytes-derived macrophages the key cell types involved progression NAFLD, non-alcoholic steatohepatitis (NASH), hepatocellular carcinoma (HCC). Their unique polarization contributes NAFLD. KCs phagocytes self-renewal abilities play regulating maintaining homeostasis. Upon damage, activated colonized at site damaged tissue. The secretion inflammatory cytokines chemokines by pivotal initiating pathogenesis. This review briefly describes system focuses on pathological molecular pathways recruited macrophages. In addition, relationship between insulin resistance described. Finally, latest therapeutics that target summarized prevention treatment

Language: Английский

Citations

39