Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(5), P. 669 - 669
Published: May 5, 2025
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
growing
global
health
concern,
impacting
approximately
32.4%
of
the
worldwide
population.
As
linked
to
metabolic
dysfunction,
NAFLD
continues
rise
alongside
increases
in
obesity,
type
2
diabetes
mellitus
(T2DM),
and
syndrome.
There
considerable
evidence
indicating
that
disproportionately
affects
racial,
ethnic,
minority
groups,
although
exact
reasons
for
these
disparities
remain
elusive.
Contributing
factors
this
may
include
socioeconomic
status,
cultural
influences,
stress,
genetic
factors,
lifestyle
choices.
Emerging
suggests
causal
could
influence
epigenetic
mechanisms,
particularly
DNA
methylation
histone
modifications,
as
well
composition
diversity
gut
microbiota.
Nevertheless,
there
scarcity
research
comprehensively
examines
interplay
between
changes
microbiome
variations
relation
across
different
racial
ethnic
populations
globally.
This
paper
intends
(i)
explore
connections
NAFLD,
disparities,
microbiota
composition,
alterations,
while
reviewing
pertinent
studies
illustrate
how
contribute
inequities
among
various
groups
impacted
by
disease;
(ii)
potential
therapeutic
targets
biomarkers
advance
management
NAFLD;
(iii)
provide
insights
enhance
our
understanding
mechanisms
associated
with
disease,
thereby
promoting
further
field.
Advancements
area
are
anticipated
susceptibilities
at-risk
new
options
its
complications.
World Journal of Gastroenterology,
Journal Year:
2023,
Volume and Issue:
29(22), P. 3400 - 3421
Published: June 6, 2023
Small
intestinal
bacterial
overgrowth
(SIBO)
is
defined
as
an
increase
in
the
content
of
small
intestine
above
normal
values.
The
presence
SIBO
detected
33.8%
patients
with
gastroenterological
complaints
who
underwent
a
breath
test,
and
significantly
associated
smoking,
bloating,
abdominal
pain,
anemia.
Proton
pump
inhibitor
therapy
significant
risk
factor
for
SIBO.
increases
age
does
not
depend
on
gender
or
race.
complicates
course
number
diseases
may
be
pathogenetic
significance
development
their
symptoms.
functional
dyspepsia,
irritable
bowel
syndrome,
constipation,
diarrhea,
short
chronic
pseudo-obstruction,
lactase
deficiency,
diverticular
celiac
diseases,
ulcerative
colitis,
Crohn's
disease,
cirrhosis,
metabolic-associated
fatty
liver
disease
(MAFLD),
primary
biliary
cholangitis,
gastroparesis,
pancreatitis,
cystic
fibrosis,
gallstone
diabetes,
hypothyroidism,
hyperlipidemia,
acromegaly,
multiple
sclerosis,
autism,
Parkinson's
systemic
spondylarthropathy,
fibromyalgia,
asthma,
heart
failure,
other
diseases.
often
slowdown
orocecal
transit
time
that
decreases
clearance
bacteria
from
intestine.
this
due
to
motor
dysfunction
gut,
autonomic
diabetic
polyneuropathy,
portal
hypertension,
decrease
motor-stimulating
influence
thyroid
hormones.
In
including
MAFLD,
association
was
found
between
severity
Further
work
effect
eradication
condition
prognosis
various
required.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(5), P. e26991 - e26991
Published: Feb. 27, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
stress-induced
injury
related
to
heredity,
environmental
exposure
and
the
gut
microbiome
metabolism.
Short-chain
acids
(SCFAs),
metabolites
of
microbiota
(GM),
participate
in
regulation
hepatic
steatosis
inflammation
through
gut-liver
axis,
which
play
an
important
role
alleviation
NAFLD.
However,
little
progress
has
been
made
systematically
elucidating
mechanism
how
SCFAs
improve
NAFLD,
especially
epigenetic
mechanisms
potential
therapeutic
application
as
clinical
treatment
for
Herein,
we
adopted
PubMed
Medline
search
relevant
keywords
such
'SCFAs',
'NAFLD',
'gut
microbiota',
'Epigenetic',
'diet',
'prebiotic
effect'
review
latest
research
on
NAFLD
up
November
2023.
In
this
review,
firstly,
specifically
discussed
production
function
SCFAs,
well
their
crosstalk
coordination
axis.
Secondly,
provided
updated
summary
intensive
discussion
affect
alleviate
from
perspective
genetic
epigenetic.
Thirdly,
paid
attention
pharmacological
physiological
characteristics
proposed
promising
future
direction
adopt
alone
or
combination
with
prebiotics
drugs
prevent
treat
Together,
aimed
elucidate
provide
new
insights
prospects
target
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3694 - 3694
Published: March 26, 2024
Metabolic-associated
fatty
liver
disease
(MAFLD)
includes
several
metabolic
dysfunctions
caused
by
dysregulation
in
the
brain–gut–liver
axis
and,
consequently,
increases
cardiovascular
risks
and
dysfunction.
In
MAFLD,
type
2
diabetes
mellitus,
obesity,
syndrome
are
frequently
present;
these
conditions
related
to
lipogenesis
systemic
inflammation.
This
study
aimed
review
connection
between
MAFLD.
The
inflammatory
process,
cellular
alterations
hepatocytes
stellate
cells,
hypercaloric
diet,
sedentarism
aggravate
prognosis
of
patients
with
Thus,
understand
modulation
physiopathology
it
is
necessary
include
organokines
involved
this
process
(adipokines,
myokines,
osteokines,
hepatokines)
their
clinical
relevance
project
future
perspectives
condition
bring
light
new
possibilities
therapeutic
approaches.
Adipokines
responsible
for
activation
distinct
signaling
different
tissues,
such
as
insulin
pro-inflammatory
cytokines,
which
important
balancing
substances
avoid
MAFLD
its
progression.
Myokines
improve
quantity
quality
adipose
contributing
avoiding
development
Finally,
hepatokines
decisive
improving
or
not
progression
through
regulation
anti-inflammatory
organokines.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(2), P. 269 - 269
Published: Jan. 16, 2024
Nutrition
is
one
of
the
most
influential
environmental
factors
in
both
taxonomical
shifts
gut
microbiota
as
well
development
type
2
diabetes
mellitus
(T2DM).
Emerging
evidence
has
shown
that
effects
nutrition
on
these
parameters
not
mutually
exclusive
and
changes
related
metabolites
such
short-chain
fatty
acids
(SCFAs)
branched-chain
amino
(BCAAs)
may
influence
systemic
inflammation
signaling
pathways
contribute
to
pathophysiological
processes
associated
with
T2DM.
With
this
background,
our
review
highlights
macronutrients,
carbohydrates,
proteins,
lipids,
micronutrients,
vitamins,
minerals,
T2DM,
specifically
through
their
alterations
they
produce.
Additionally,
we
describe
influences
common
food
groups,
which
incorporate
varying
combinations
macronutrients
metabolic
context
mellitus.
Overall,
first
line
modifiable
therapies
management
T2DM
a
better
understanding
mechanisms
by
its
pathophysiology
provides
opportunities
for
optimizing
dietary
interventions.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 20, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
prevalent
chronic
condition
observed
globally,
with
the
potential
to
progress
non-alcoholic
steatohepatitis
(NASH),
cirrhosis,
and
even
hepatocellular
carcinoma.
Currently,
US
Food
Drug
Administration
(FDA)
has
not
approved
any
drugs
for
treatment
of
NAFLD.
NAFLD
characterized
by
histopathological
abnormalities
in
liver,
such
as
lipid
accumulation,
steatosis,
hepatic
balloon
degeneration,
inflammation.
Dysbiosis
gut
microbiota
its
metabolites
significantly
contribute
initiation
advancement
Bacteroides
,
probiotic,
shown
strong
preventing
onset
progression
However,
precise
mechanism
which
treats
remains
uncertain.
In
this
review,
we
explore
current
understanding
role
NAFLD,
focusing
on
their
ability
reduce
inflammation,
mitigate
enhance
intestinal
barrier
function.
Additionally,
summarize
how
alleviates
pathological
changes
restoring
metabolism,
improving
insulin
resistance,
regulating
cytokines,
promoting
tight-junctions.
A
deeper
comprehension
mechanisms
through
involved
pathogenesis
should
aid
development
innovative
targeting
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2838 - 2838
Published: Aug. 24, 2024
The
gut
microbiota
constitutes
a
complex
ecosystem,
comprising
trillions
of
microbes
that
have
co-evolved
with
their
host
over
hundreds
millions
years.
Over
the
past
decade,
growing
body
knowledge
has
underscored
intricate
connections
among
diet,
microbiota,
and
human
health.
Bioactive
polysaccharides
(BPs)
from
natural
sources
like
medicinal
plants,
seaweeds,
fungi
diverse
biological
functions
including
antioxidant,
immunoregulatory,
metabolic
activities.
Their
effects
are
closely
tied
to
which
metabolizes
BPs
into
health-influencing
compounds.
Understanding
how
interact
is
critical
for
harnessing
potential
health
benefits.
This
review
provides
an
overview
focusing
on
its
role
in
diseases
obesity,
type
II
diabetes
mellitus,
non-alcoholic
fatty
liver
disease,
cardiovascular
diseases.
It
explores
basic
characteristics
several
impact
microbiota.
Given
significance
health,
we
summarize
these
BPs,
particularly
terms
immunoregulatory
activities,
blood
sugar,
hypolipidemic
effect,
thus
providing
valuable
reference
understanding
benefits
treating
These
properties
make
promising
agents
preventing
comprehensive
mechanisms
by
exert
through
opens
new
avenues
developing
targeted
therapies
improve