Complement as a vital nexus of the pathobiological connectome for acute respiratory distress syndrome: An emerging therapeutic target DOI Creative Commons
Zhangsheng Yang, Susannah E. Nicholson,

Tomas S. Cancio

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 17, 2023

The hallmark of acute respiratory distress syndrome (ARDS) pathobiology is unchecked inflammation-driven diffuse alveolar damage and alveolar-capillary barrier dysfunction. Currently, therapeutic interventions for ARDS remain largely limited to pulmonary-supportive strategies, there an unmet demand pharmacologic therapies targeting the underlying pathology in patients suffering from illness. complement cascade (ComC) plays integral role regulation both innate adaptive immune responses. ComC activation can prime overzealous cytokine storm tissue/organ damage. lung injury (ALI) have established relationship with early maladaptive activation. In this review, we collected evidence current studies linking ALI/ARDS dysregulation, focusing on elucidating new emerging roles extracellular (canonical) intracellular (non-canonical or complosome), (complementome) pathobiology, highlighting complementome as a vital nexus pathobiological connectome via its crosstalking other systems immunome, DAMPome, PAMPome, coagulome, metabolome, microbiome. We also discussed diagnostic/therapeutic potential future direction care ultimate goal better defining mechanistic subtypes (endotypes theratypes) through methodologies order facilitate more precise effective complement-targeted therapy treating these comorbidities. This information leads support anti-inflammatory strategy by ComC, where arsenal clinical-stage complement-specific drugs available, especially due COVID-19.

Language: Английский

COVID-19 and the antiphospholipid syndrome DOI
Manuel Serrano, Gerard Espinosa, Antonio Serrano

et al.

Autoimmunity Reviews, Journal Year: 2022, Volume and Issue: 21(12), P. 103206 - 103206

Published: Oct. 3, 2022

Language: Английский

Citations

28
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups DOI Creative Commons
Lisa Hurler, Ágnes Szilágyi, Federica Mescia

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 27, 2023

Introduction While complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), protein shown interact with SARS-CoV-2 proteins. However, exact role of and its key molecule MBL COVID-19 still not fully understood. Methods We therefore investigated two independent cohorts infected patients, while also analysing levels potential effects six major single nucleotide polymorphisms (SNPs) found MBL2 gene on outcome. Results show that COVID-19, indicated correlation between product MASP-1/C1-INH complex (p=0.0011) C4d (p<0.0001) severity. Despite this, genetic variations are associated susceptibility infection or outcomes such as mortality development Long COVID. Conclusion In conclusion, MBL-LP only plays minor pathogenesis, since no clinically meaningful, consistent associations were noted.

Language: Английский

Citations

16
Overview of the SARS-CoV-2 nucleocapsid protein DOI

Ahmed Eltayeb,

Faisal Al‐Sarraj, Mona G. Alharbi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129523 - 129523

Published: Jan. 15, 2024

Language: Английский

Citations

5
SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment DOI Creative Commons
Khalil Khalaf,

Natalia Papp,

Jadzia Tin-Tsen Chou

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Oct. 6, 2020

The emergence and rapid spread of SARS-CoV-2 in December 2019 has brought the world to a standstill. While less pathogenic than 2002-2003 SARS-CoV, this novel

Language: Английский

Citations

36
Complement as a vital nexus of the pathobiological connectome for acute respiratory distress syndrome: An emerging therapeutic target DOI Creative Commons
Zhangsheng Yang, Susannah E. Nicholson,

Tomas S. Cancio

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 17, 2023

The hallmark of acute respiratory distress syndrome (ARDS) pathobiology is unchecked inflammation-driven diffuse alveolar damage and alveolar-capillary barrier dysfunction. Currently, therapeutic interventions for ARDS remain largely limited to pulmonary-supportive strategies, there an unmet demand pharmacologic therapies targeting the underlying pathology in patients suffering from illness. complement cascade (ComC) plays integral role regulation both innate adaptive immune responses. ComC activation can prime overzealous cytokine storm tissue/organ damage. lung injury (ALI) have established relationship with early maladaptive activation. In this review, we collected evidence current studies linking ALI/ARDS dysregulation, focusing on elucidating new emerging roles extracellular (canonical) intracellular (non-canonical or complosome), (complementome) pathobiology, highlighting complementome as a vital nexus pathobiological connectome via its crosstalking other systems immunome, DAMPome, PAMPome, coagulome, metabolome, microbiome. We also discussed diagnostic/therapeutic potential future direction care ultimate goal better defining mechanistic subtypes (endotypes theratypes) through methodologies order facilitate more precise effective complement-targeted therapy treating these comorbidities. This information leads support anti-inflammatory strategy by ComC, where arsenal clinical-stage complement-specific drugs available, especially due COVID-19.

Language: Английский

Citations

13