The pyroptotic role of Caspase-3/GSDME signalling pathway among various cancer: A Review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124832 - 124832

Published: May 15, 2023

Language: Английский

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TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors

Cancer Immunology Immunotherapy, Journal Year: 2023, Volume and Issue: 72(11), P. 3405 - 3425

Published: Aug. 11, 2023

T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential wide range of neoplasms. TIM-3 is one the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 CEACAM1. Initially identified on surface T helper 1 (Th1) lymphocytes later cytotoxic (CTLs), monocytes, macrophages, natural killer cells (NKs), dendritic (DCs), plays role immunoregulation. Recently, growing body evidence shown various tumor types indicates specific prognosis for cancer patients. Here, we discuss which can serve as prognostic factor influence coexpressed inhibitors, such LAG-3, PD-1, CTLA-4 patients' outcomes. Currently, experimental medicine involving significantly enhanced anti-tumor effect improved patient survival. In this work, summarized clinical trials incorporating targeting monoclonal bispecific antibodies monotherapy combination therapy highlighted emerging cell-based therapies.

Language: Английский

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Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge

Cancers, Journal Year: 2023, Volume and Issue: 15(9), P. 2639 - 2639

Published: May 6, 2023

Despite the decline in incidence and mortality rates, gastric cancer (GC) is fifth leading cause of deaths worldwide. The GC are exceptionally high Asia due to H. pylori infection, dietary habits, smoking behaviors, heavy alcohol consumption. In Asia, males more susceptible developing than females. Variations strains prevalence rates may contribute differences across Asian countries. Large-scale eradication was one effective ways reduce incidences. Treatment methods clinical trials have evolved, but 5-year survival rate advanced still low. Efforts should be put towards large-scale screening early diagnosis, precision medicine, deep mechanism studies on interplay cells microenvironments for dealing with peritoneal metastasis prolonging patients’ survival.

Language: Английский

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Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 8, 2024

Abstract Circular RNAs (circRNAs) play important roles in gastric cancer progression but the regulatory role of circRNAs controlling macrophage function remains elusive. Exosomes serve as cargo for and a crucial mediators facilitating communication between cells tumor microenvironment. In this study, we found that circATP8A1, previously unreported circular RNA, is highly expressed both tissues exosomes derived from plasma. Increased circATP8A1 was associated with advanced TNM stage worse prognosis patients cancer. We showed knockdown significantly inhibited proliferation invasion vitro vivo. Functionally, exosome induced M2 polarization macrophages through STAT6 pathway instead STAT3 pathway. Mechanistically, shown to activate competitive binding miR-1-3p, confirmed by Fluorescence Situ Hybridization (FISH), RNA immunoprecipitation, pulldown, Luciferase reporter assays. The reversal circATP8A1-induced activation observed upon blocking miR-1-3p. Macrophages treated overexpressing were able promote migration, while reversed these effects summary, exosome-derived induce via circATP8A1/miR-1-3p/STAT6 axis, progression. Our results highlight potential prognostic biomarker therapeutic target

Language: Английский

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Signaling pathways of oxidative stress response: the potential therapeutic targets in gastric cancer

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 18, 2023

Gastric cancer is one of the top causes cancer-related death globally. Although novel treatment strategies have been developed, attempts to eradicate gastric proven insufficient. Oxidative stress continually produced and present in human body. Increasing evidences show that oxidative contributes significantly development cancer, either through initiation, promotion, progression cells or causing cell death. As a result, purpose this article review role response subsequent signaling pathways as well potential stress-related therapeutic targets cancer. Understanding pathophysiology developing new therapies for depends on more researches focusing contributors carcinogenesis.

Language: Английский

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METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4

Oncogene, Journal Year: 2024, Volume and Issue: 43(30), P. 2338 - 2354

Published: June 15, 2024

Abstract N 6 -methyladenosine (m A) is the predominant post-transcriptional RNA modification in eukaryotes and plays a pivotal regulatory role various aspects of fate determination, such as mRNA stability, alternative splicing, translation. Dysregulation critical m A methyltransferase METTL3 implicated tumorigenesis development. Here, this work showed that upregulated gastric cancer tissues associated with poor prognosis. methylates A2318 site within coding sequence (CDS) region STAT5A. IGF2BP2 recognizes binds METTL3-mediated STAT5A through its GXXG motif KH3 KH4 domains, leading to increased stability mRNA. In addition, both are positively correlated human tissue samples. Helicobacter pylori infection expression level cells, thereby upregulation Functional studies indicated overexpression markedly enhances proliferation migration GC whereas knockdown has inhibitory effects. Further nude mouse experiments effectively inhibits growth metastasis vivo. Moreover, transcription factor, represses KLF4 by binding promoter region. The can counteract oncogenic impact Overall, study highlights crucial provides potential therapeutic targets for cancer.

Language: Английский

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The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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Formation of a traditional Chinese medicine self-assembly nanostrategy and its application in cancer: a promising treatment

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: June 6, 2023

Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a variety of illnesses, its popularity is increasing worldwide. However, the clinical applications natural active components in TCM are hindered by poor solubility low bioavailability these compounds. To address issues, self-assembly nanostrategy (CSAN) being developed. Many possess properties, allowing them form nanoparticles (NPs) through various noncovalent forces. Self-assembled NPs (SANs) also present decoctions, they closely linked therapeutic effects remedies. SAN gaining nano research field due simplicity, eco-friendliness, enhanced biodegradability biocompatibility compared traditional preparation methods. The ingredients from that exhibit antitumour or combined with other drugs generated considerable interest cancer therapeutics. This paper provides review principles forms CSAN, as well an overview recent reports on can be self-assembly. Additionally, application CSAN diseases summarized, finally, concluding summary thoughts proposed. We strongly believe potential offer fresh strategies perspectives modernization TCM.

Language: Английский

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Reactive Oxygen Species and H. pylori Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1712 - 1712

Published: Sept. 2, 2023

Gastric cancer (GC) is the fifth most common worldwide and makes up a significant component of global burden. Helicobacter pylori (H. pylori) influential risk factor for GC, with International Agency Research on Cancer classifying it as Class I carcinogen GC. H. has been shown to persist in stomach acid decades, causing damage stomach’s mucosal lining, altering gastric hormone release patterns, potentially function. Epidemiological studies have that eliminating reduces metachronous cancer. Evidence shows various molecular alterations are present precancerous lesions associated an infection. However, although can cause oxidative stress-induced cancer, antioxidants being treatment exact mechanism underlying GC etiology not fully understood. This review provides overview recent research exploring pathophysiology pylori-induced stress antioxidant supplements reduce or even eliminate occurrence.

Language: Английский

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DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF‐1α Ubiquitination and Degradation

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

The extracellular matrix (ECM) has been demonstrated to be dysregulated and crucial for malignant progression in gastric cancer (GC), but the mechanism is not well understood. Here, that discoidin domain receptor 1 (DDR1), a principal ECM receptor, recognized as key driver of GC reported. Mechanistically, DDR1 directly interacts with PAS hypoxia-inducible factor-1α (HIF-1α), suppresses its ubiquitination subsequently strengthens transcriptional regulation angiogenesis. Additionally, upregulation cells promotes actin cytoskeleton reorganization by activating HIF-1α/ Ras Homolog Family Member A (RhoA)/Rho-associated protein kinase (ROCK1) signaling, which turn enhances metastatic capacity. Pharmacological inhibition angiogenesis patient-derived xenograft (PDX) organoid models. Taken together, this work first indicates effects DDR1-HIF-1α axis on reveals related mechanisms, providing experimental evidence therapeutic target GC.

Language: Английский

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