Cited by Coronavirus Disease 2019 Histology and Histopathology

Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy DOI

Yi Wang, Laurence Don Wai Luu, Shuang Liu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 18, 2023

Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial developing effective treatments. Here, we utilized single-cell transcriptomic analysis integrated clinical observations laboratory examination to dissect host immune responses reveal pathological in pediatric encephalopathy. We found that lymphopenia was a prominent characteristic of perturbation COVID-19 patients with encephalopathy, especially those acute necrotizing (AE). This characterized marked reduction various lymphocytes (e.g., CD8+ T CD4+ cells) significant increases other inflammatory cells monocytes). Further revealed activation multiple cell apoptosis pathways granzyme/perforin-, FAS- TNF-induced apoptosis) may be responsible lymphopenia. A systemic S100A12 upregulation, primarily from classical monocytes, have contributed cytokine storms AE. dysregulated type I interferon (IFN) response observed which further exacerbated S100A12-driven inflammation In AE, myeloid monocytic myeloid-derived suppressor were likely contributors paralysis. Finally, landscape also by NK widespread exhaustion, higher cytotoxic scores as well B cell-mediated humoral response. Taken together, this comprehensive data provides detailed resource elucidating immunopathogenesis will aid development treatments,

Language: Английский

Citations

SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model DOI

Bina Lee,

Ha Nyeoung Choi,

Young Se Hyun

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(5), P. 101570 - 101570

Published: May 1, 2024

While an association between Parkinson's disease (PD) and viral infections has been recognized, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PD progression remains unclear. Here, we demonstrate that SARS-CoV-2 infection heightens risk using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons a angiotensin-converting enzyme (hACE2) transgenic (Tg) mouse model. Our findings reveal exacerbates susceptibility cellular toxicity in DA pre-treated with preformed fibrils (hPFFs). Additionally, nasally delivered infects hACE2 Tg mice, aggravating damage initiated by hPFFs. Mice infected display persisting neuroinflammation even after virus is no longer detectable brain. A comprehensive analysis suggests inflammatory response mediated astrocytes microglia could contribute to increased associated SARS-CoV-2. These advance our understanding potential long-term effects PD.

Language: Английский

Citations

Proteomic and phosphoproteomic characteristics of the cortex, hippocampus, thalamus, lung, and kidney in COVID-19-infected female K18-hACE2 mice DOI

Jiang-Feng Liu,

Wan-Jun Peng,

Yue Wu

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104518 - 104518

Published: March 16, 2023

Language: Английский

Citations

On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review DOI

Noa van der Knaap, Marcel Aries, Iwan C.C. van der Horst

et al.

NeuroImage Clinical, Journal Year: 2024, Volume and Issue: 42, P. 103589 - 103589

Published: Jan. 1, 2024

Many Coronavirus Disease 2019 (COVID-19) patients are suffering from long-term neuropsychological sequelae. These may benefit a better understanding of the underlying neuropathophysiological mechanisms and identification potential biomarkers treatment targets. Structural clinical neuroimaging techniques have limited ability to visualize subtle cerebral abnormalities investigate brain function. This scoping review assesses merits advanced in COVID-19 using literature including or postmortem analyses adult published start pandemic until December 2023. Findings were summarized according distinct categories reported revealed by different imaging techniques. Although no unified COVID-19-specific pattern could be subtracted, broad range (likely attributable hypoxic, vascular, inflammatory pathology), even absence structural findings. validated examinations. emphasizes added value compared highlights implications for functioning consequences COVID-19.

Language: Английский

Citations

Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study DOI

H. Alexander Chen,

Ling Li,

Y P Sun

et al.

Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 97 - 113

Published: Jan. 1, 2025

COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying problems (SP) post-COVID-19 are unclear. This study investigated SP-related brain functional connectivity (FC) alterations. Fifty-five survivors with SP (COVID_SP) 33 without (COVID_NSP), matched for demographics, completed PSQI underwent rs-fMRI at baseline 2-month follow-up. Correlations between FC clinical data were analyzed by Pearson correlation analysis Gaussian random field (GRF) correction. The repeated-measures variance (R-M ANOVA) was explore the interaction time. At baseline, COVID_SP exhibited elevated FC: right precentral gyrus (PrG) left lateral occipital cortex (LOcC)/right PrG, inferior parietal lobule (IPL) superior frontal (SFG), hippocampus (IFG). Higher SFG correlated scores. follow-up, decreased implicated in emotion regulation, executive function, memory; increased semantics, attention, auditory-visual processing. these regions scores PSQI, GAD, PHQ. Repeated-Measures Analysis Variance revealed a significant time effect various scales. Moreover, PrG as well that IPL also discovered effect. provides insight into associated after COVID-19. These may partially explain development SP, they changed over

Language: Английский

Citations

Virally-initiated pain states: phenotype, mechanisms, and future directions DOI

Sara A. Dochnal, Steven P. Cohen, Mark R. Hutchinson

et al.

Frontiers in Pain Research, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 28, 2025

The recent SARS-CoV-2 pandemic has underscored the significance of viral infections, affecting billions lives and costing trillions dollars globally. Even beyond SARS-CoV-2, common infections with viruses like influenza, HIV, herpesviruses have profound impacts their typical manifestations, often triggering acute chronic pain syndromes that can be life-altering. These virally induced states arise through direct replication within neurons, or indirectly, via immune responses to infection in both contexts afferent signaling dorsal root ganglion (DRG) subsequent higher order integration intracranial systems. Varicella-zoster virus (VZV), influenza virus, each provide a unique lens which examine interplay between activity pain. This perspective paper is not meant an exhaustive review virally-induced neuropathic states. It seeks explore curated aspects complexities these states, identify research gaps, suggest solutions using nanoscale molecular understanding psychoneuroimmunological biopsychosocial frameworks. Each subheading accompanied by list related issues for study we think will lead advances our vexing phenotype associated infection.

Language: Английский

Citations

COVID‐19‐Associated White Lung Correlates With the Dysfunctional Neutrophil Response Revealed by Single‐Cell Immune Profiling DOI

Yi Wang, Xiaoxia Wang, Xiong Zhu

et al.

MedComm – Future Medicine, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 27, 2025

Language: Английский

Citations

Potential role for kynurenine pathway in increased COVID-19 mortality of patients with schizophrenia DOI

Pengli Wang,

Zhen-Ying Li,

Jie Wang

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 183, P. 289 - 295

Published: Feb. 21, 2025

Language: Английский

Citations

Clinical Manifestations of SARS-CoV-2 Infection in Immunocompetent Adults in the Era of Widespread Population Immunity and Omicron Sublineage Viruses DOI

Alexander Shaffer, Eric A. Meyerowitz

Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants DOI

Yuanyuan Wu, Raúl Andrés Vallejo Serna, Wen Qi Gan

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 17, 2025

Contributions of leukocytes to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) defense have been reported extensively. However, it remains unclear whether there are different leukocyte responses ancestral SARS-CoV-2 and its variants. We analyzed peripheral blood subtype concentrations from 575 COVID-19 patients 950 non-COVID-19 subjects registered at the University Connecticut John Dempsey Hospital between 2020 2022, which covers strain, Delta, Omicron found that neutrophils, immature granulocytes, monocytes were elevated, lymphocytes reduced after infection. These hyperactive neutrophils/immature granulocytes suppressed lymphocytes/monocytes associated with poorer prognosis in strain Different not shown decedents Delta infection, granulocyte concentration was observed be mortality. In decedents, lymphocyte/monocyte Our findings provided insights into immune SARS-CoV-2,

Language: Английский

Citations