The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity DOI Creative Commons

Hao Wu,

J.F. Liu, Xinghua Zhang

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 80, P. 101222 - 101222

Published: Feb. 28, 2025

Patients with breast cancer (BC) who benefit from the PD-1/PD-L1 inhibitor (PDi) is limited, necessitating novel strategies to improve immunotherapy efficacy of BC. Here we aimed investigate inhibitory effects flaxseed lignans (FL) on biological behaviors BC and evaluate roles FL in enhancing anticancer PDi. HPLC was used detect content enterolactone (ENL), bacterial transformation product FL. Transcript sequencing performed identified CD38 as a downstream target gene ENL. CD38-overexpressing cells were constructed cell proliferation, colony formation, wound healing transwell assays assess function ENL/CD38 axis vitro. Multiplexed immunohistochemistry (mIHC) CyTOF changes tumor immune microenvironment (TIM). 16S rDNA explore gut microbiota mice. A series vivo experiments conducted mechanisms converted ENL by administration inhibited progression malignant downregulating CD38, key associated immunosuppression blockade resistance. The mIHC assay revealed that enhanced CD3+, CD4+ CD8+ reduced F4/80+ TIM. confirmed regulatory combination PDi (FLcPDi) In addition, analysis demonstrated FLcPDi treatment significantly elevated abundance Akkermansia and, importantly, response mice treated antibiotics. FL/ENL/CD38 progression. modulating host immunity.

Language: Английский

Signaling pathways and targeted therapies for psoriasis DOI Creative Commons
Jia Guo, H. Zhang,

Wenrui Lin

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 27, 2023

Abstract Psoriasis is a common, chronic, and inflammatory skin disease with high burden on individuals, health systems, society worldwide. With the immunological pathologies pathogenesis of psoriasis becoming gradually revealed, therapeutic approaches for this have gained revolutionary progress. Nevertheless, mechanisms less common forms remain elusive. Furthermore, severe adverse effects recurrence upon treatment cessation should be noted addressed during treatment, which, however, has been rarely explored integration preliminary findings. Therefore, it crucial to comprehensive understanding behind pathogenesis, which might offer new insights research lead more substantive progress in expand clinical options treatment. In review, we looked briefly introduce epidemiology, subtypes, pathophysiology, comorbidities systematically discuss signaling pathways involving extracellular cytokines intracellular transmission, as well cross-talk between them. discussion, also paid attention potential metabolic epigenetic molecular mechanistic cascades related its comorbidities. This review outlined current psoriasis, especially targeted therapies novel strategies, mechanism recurrence.

Language: Английский

Citations

127
γδ T cells: origin and fate, subsets, diseases and immunotherapy DOI Creative Commons
Yi Hu,

Qinglin Hu,

Yongsheng Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 22, 2023

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering use allogeneic Vδ2

Language: Английский

Citations

111
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives DOI Creative Commons

Ke-Yu Shen,

Ying Zhu,

Sun‐Zhe Xie

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 29, 2024

Abstract Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. In recent years, immunotherapies such as immune checkpoint inhibitors (ICIs) have made great progress in the systemic treatment of HCC. The combination treatments based on ICIs been trend this area. Recently, dual blockade durvalumab plus tremelimumab has also emerged an effective for advanced However, majority HCC patients obtain benefits. Understanding immunological rationale exploring novel ways to improve efficacy immunotherapy drawn much attention. review, we summarize latest area, ongoing clinical trials immune-based therapies, well strategies chimeric antigen receptor T cells, personalized neoantigen vaccines, oncolytic viruses, bispecific antibodies.

Language: Английский

Citations

41
Neutrophil extracellular traps in homeostasis and disease DOI Creative Commons

Han Wang,

Susan J. Kim,

Lei Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

29
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion DOI Creative Commons
Uğur Uslu, Lijun Sun, Sofia Castelli

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 10, 2024

Abstract As a strategy to improve the therapeutic success of chimeric antigen receptor T cells (CART) directed against solid tumors, we here test combinatorial use CART and IMSA101, newly developed stimulator interferon genes (STING) agonist. In two syngeneic tumor models, improved overall survival is observed when mice are treated with intratumorally administered IMSA101 in addition intravenous infusion. Transcriptomic analyses isolated from tumors show elevated cell activation, as well upregulated cytokine pathway signatures, particular IL-18, combination treatment group. Also, higher levels IL-18 serum detected treatment. Consistent this, negative impair anti-tumor responses receiving summary, find that enhances function which facilitated through STING agonist-induced secretion.

Language: Английский

Citations

19
The role of microRNAs in the gastric cancer tumor microenvironment DOI Creative Commons
Xianzhe Yu,

Yin Zhang,

Fengming Luo

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 20, 2024

Gastric cancer (GC) is one of the deadliest malignant tumors with unknown pathogenesis. Due to its treatment resistance, high recurrence rate, and lack reliable early detection techniques, a majority patients have poor prognosis. Therefore, identifying new tumor biomarkers therapeutic targets essential. This review aims provide fresh insights into enhancing prognosis GC by summarizing processes through which microRNAs (miRNAs) regulate microenvironment (TME) highlighting their critical role in TME. A comprehensive literature was conducted focusing on interactions among cells, extracellular matrix, blood vessels, cancer-associated fibroblasts, immune cells within The noncoding RNAs, known as miRNAs, modulating TME various signaling pathways, cytokines, growth factors, exosomes specifically examined. Tumor formation, metastasis, therapy are significantly influenced miRNAs progression these multiple exosomes. Dysregulation affects cellular such cell proliferation, differentiation, angiogenesis, contributing pathogenesis GC. play crucial regulation TME, influencing patient By understanding mechanisms control potential can be identified improve

Language: Английский

Citations

17
Nanoceria as a non-steroidal anti-inflammatory drug for endometriosis theranostics DOI
Md Saidur Rahman, Kay Hadrick, Seock‐Jin Chung

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 1015 - 1029

Published: Jan. 5, 2025

Language: Английский

Citations

3
Structural characterization of two γδ TCR/CD3 complexes DOI Creative Commons
Mohammed Hoque,

John Benji Grigg,

Trudy F. Ramlall

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Language: Английский

Citations

2
The Role of Memory T-Cell Mediated Immunity in Long-term COVID-19: Effects of Vaccination Status. DOI

Saulesh Kurmangaliyeva,

Akzhan M. Madenbayeva, Saltanat T. Urazayeva

et al.

PubMed, Journal Year: 2025, Volume and Issue: 50(2), P. 61 - 68

Published: Feb. 1, 2025

T-cell-mediated immunity is essential for controlling severe acute respiratory syndrome coronavirus 2 (SARSCoV2) infection, preventing disease, and potentially reducing the risk of long-term disease (COVID). This study investigated impact natural vaccination, hybrid on T-cell responses, with a particular emphasis role memory T-cells in COVID-19. The present reviewed current literature including development, individuals SARS-CoV-2 those vaccinated messenger RNA (mRNA) vaccines, immunity. It examined studies that compared activity, immune regulation, prevalence COVID-19 across these groups. Natural infection induces variable cases showing stronger but sometimes dysregulated immunological which may contribute to prolonged Vaccination, particularly mRNA elicits targeted consistent T-cells, severity, incidence Hybrid combines provides most robust protection, enhanceds reduces through balanced regulation. Memory play critical mitigating Vaccination significantly enhances immunity, minimizing chronic symptoms alone. effective defense, emphasizing importance even after prevent

Language: Английский

Citations

2
Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum DOI Creative Commons
Joline Ingels, Laurenz De Cock,

Dieter Stevens

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(5), P. 101516 - 101516

Published: April 15, 2024

Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in early stages. Here, we present the results of a phase I clinical trial which dendritic (DC) vaccine targeting patient-individual neoantigens evaluated patients with resected NSCLC. Vaccine manufacturing feasible six 10 enrolled patients. Toxicity limited to grade 1-2 adverse events. Systemic T responses are observed five out vaccinated patients, remaining detectable up 19 months post vaccination. Single-cell analysis indicates that responsive population polyclonal and exhibits near-entire spectrum differentiation states, including naive-like state, but excluding exhausted states. Three experience disease recurrence during follow-up period 2 years. Collectively, these data support feasibility, safety, immunogenicity this treatment

Language: Английский

Citations

14