Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

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Biologics, theranostics, and personalized medicine in drug delivery systems

Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107086 - 107086

Published: Jan. 29, 2024

The progress in human disease treatment can be greatly advanced through the implementation of nanomedicine. This approach involves targeted and cell-specific therapy, controlled drug release, personalized dosage forms, wearable delivery, companion diagnostics. By integrating cutting-edge technologies with delivery systems, greater precision achieved at tissue cellular levels use stimuli-responsive nanoparticles, development electrochemical sensor systems. targeting – by virtue nanotechnology allows for therapy to directed specifically affected tissues while reducing side effects on healthy tissues. As such, nanomedicine has potential transform conditions such as cancer, genetic diseases, chronic illnesses facilitating precise delivery. Additionally, forms devices offer ability tailor unique needs each patient, thereby increasing therapeutic effectiveness compliance. Companion diagnostics further enable efficient monitoring response, enabling customized adjustments plan. question whether all approaches outlined here are viable alternatives current treatments is also discussed. In general, application field biomedicine may provide a strong alternative existing several reasons. this review, we aim present evidence that, although early stages, fully merging technology innovative shows promise successful across various areas, including cancer or diseases.

Language: Английский

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Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Jan. 5, 2024

This review article explores the dynamic field of radiopharmaceuticals, where innovative developments arise from combining radioisotopes and pharmaceuticals, opening up exciting therapeutic possibilities. The in-depth exploration covers targeted drug delivery, delving into passive targeting through enhanced permeability retention, as well active using ligand-receptor strategies. also discusses stimulus-responsive release systems, which orchestrate controlled release, enhancing precision effectiveness. A significant focus is placed on crucial role radiopharmaceuticals in medical imaging theranostics, highlighting their contribution to diagnostic accuracy image-guided curative interventions. emphasizes safety considerations strategies for mitigating side effects, providing valuable insights addressing challenges achieving precise delivery. Looking ahead, nanoparticle formulations cutting-edge innovations next-generation showcasing potential applications. Real-world examples are presented case studies, including use radiolabelled antibodies solid tumors, peptide receptor radionuclide therapy neuroendocrine intricate management bone metastases. concluding perspective envisions future trajectory anticipating a harmonious integration medicine artificial intelligence. vision foresees an era aligns seamlessly with scientific advancements, ushering new epoch marked by fusion resonance visionary progress.

Language: Английский

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Nanotechnology in healthcare, and its safety and environmental risks

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Language: Английский

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Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 504 - 504

Published: April 23, 2024

Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.

Language: Английский

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Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(18), P. 4307 - 4334

Published: Jan. 1, 2024

Recent advancements pertaining to the application of GQD-based nanosystems in photothermal and photodynamic cancer therapies are discussed, highlighting crucial challenges, advantages, future perspectives.

Language: Английский

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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3432 - 3456

Published: May 13, 2024

The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.

Language: Английский

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Recent strategies to overcome breast cancer resistance

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 197, P. 104351 - 104351

Published: April 12, 2024

Breast cancer is potentially a lethal disease and leading cause of death in women. Chemotherapy radiotherapy are the most frequently used treatment options. Drug resistance advanced breast limits therapeutic output treatment. The endocrine hormonal imbalance, particularly triple negative HER2 positive cancers. efflux drugs due to p-gp's activity another resistance. resistant protein also contributes significantly. Strategies combat include use nanoparticles target drug delivery by co-delivery chemotherapeutic genes (siRNA miRNA) that help down-regulate causing siRNA specific effectively silences p-gp other proteins chemosensitizers effective overcoming Chemo-sensitizers sensitize cells effects drugs. Novel anti-neoplastic agents such as antibody-drug conjugates mesenchymal stem tools improve response cancer. Similarly, combination photo/thermal ablation with chemotherapy can act overcome In this review, we focus on mechanism nanoparticle-based strategies

Language: Английский

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Nanotechnology in medicine revolutionizing drug delivery for cancer and viral infection treatments

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 660, P. 124345 - 124345

Published: June 15, 2024

Advancements in nanotechnology were vastly applied medicine and pharmacy, especially the field of nano-delivery systems. It took a long time for these systems to ensure precise delivery very delicate molecules, such as RNA, cells at concentrations that yield remarkable efficiency, with success rates reaching 95.0% 94.5%. These days, there are several advantages using nanotechnological solutions prevention treatment cancer viral infections. Its interventions improve outcomes both due increased effectiveness drug target location by reducing adverse reactions, thereby increasing patient adherence therapy. Based on current knowledge an updated review was made, perspective, opportunities challenges nanomedicine discussed. The methods employed include comprehensive examination existing literature studies nanoparticles including vitro tests performed cell cultures vivo assessments carried out appropriate animal models, specific emphasis their applications oncology virology. This brings together various aspects structure formation well its association characteristic behaviour organisms, providing novel perspective. Furthermore, practical application pharmacy focus diseases malignancies explored. can serve valuable guide fellow researchers, helping them navigate abundance findings this field. results indicate medicinal products improving therapeutic will continue expand.

Language: Английский

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Nanoparticle-Mediated Drug Delivery Systems for Precision Targeting in Oncology

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 677 - 677

Published: May 24, 2024

Nanotechnology has emerged as a transformative force in oncology, facilitating advancements site-specific cancer therapy and personalized oncomedicine. The development of nanomedicines explicitly targeted to cells represents pivotal breakthrough, allowing the precise interventions. These cancer-cell-targeted operate within intricate milieu tumour microenvironment, further enhancing their therapeutic efficacy. This comprehensive review provides contemporary perspective on precision medicine underscores critical role nanotechnology advancing It explores categorization nanoparticle types, distinguishing between organic inorganic variants, examines significance delivery anticancer drugs. Current insights into strategies for developing actively across various types are also provided, thus addressing relevant challenges associated with drug barriers. Promising future directions nanomedicine approaches delivered, emphasising imperative continued optimization nanocarriers medicine. discussion translational research’s need enhance patients’ outcomes by refining nanocarrier technologies nanotechnology-driven, therapy.

Language: Английский

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