Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102233 - 102233
Published: Aug. 5, 2024
Language: Английский
Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107086 - 107086
Published: Jan. 29, 2024
The progress in human disease treatment can be greatly advanced through the implementation of nanomedicine. This approach involves targeted and cell-specific therapy, controlled drug release, personalized dosage forms, wearable delivery, companion diagnostics. By integrating cutting-edge technologies with delivery systems, greater precision achieved at tissue cellular levels use stimuli-responsive nanoparticles, development electrochemical sensor systems. targeting – by virtue nanotechnology allows for therapy to directed specifically affected tissues while reducing side effects on healthy tissues. As such, nanomedicine has potential transform conditions such as cancer, genetic diseases, chronic illnesses facilitating precise delivery. Additionally, forms devices offer ability tailor unique needs each patient, thereby increasing therapeutic effectiveness compliance. Companion diagnostics further enable efficient monitoring response, enabling customized adjustments plan. question whether all approaches outlined here are viable alternatives current treatments is also discussed. In general, application field biomedicine may provide a strong alternative existing several reasons. this review, we aim present evidence that, although early stages, fully merging technology innovative shows promise successful across various areas, including cancer or diseases.
Language: Английский
Citations
67
Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899
Published: July 9, 2024
This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.
Language: Английский
Citations
62
European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)
Published: Jan. 5, 2024
This review article explores the dynamic field of radiopharmaceuticals, where innovative developments arise from combining radioisotopes and pharmaceuticals, opening up exciting therapeutic possibilities. The in-depth exploration covers targeted drug delivery, delving into passive targeting through enhanced permeability retention, as well active using ligand-receptor strategies. also discusses stimulus-responsive release systems, which orchestrate controlled release, enhancing precision effectiveness. A significant focus is placed on crucial role radiopharmaceuticals in medical imaging theranostics, highlighting their contribution to diagnostic accuracy image-guided curative interventions. emphasizes safety considerations strategies for mitigating side effects, providing valuable insights addressing challenges achieving precise delivery. Looking ahead, nanoparticle formulations cutting-edge innovations next-generation showcasing potential applications. Real-world examples are presented case studies, including use radiolabelled antibodies solid tumors, peptide receptor radionuclide therapy neuroendocrine intricate management bone metastases. concluding perspective envisions future trajectory anticipating a harmonious integration medicine artificial intelligence. vision foresees an era aligns seamlessly with scientific advancements, ushering new epoch marked by fusion resonance visionary progress.
Language: Английский
Citations
48
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 15, 2024
Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract
Language: Английский
Citations
27
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(18), P. 4307 - 4334
Published: Jan. 1, 2024
Recent advancements pertaining to the application of GQD-based nanosystems in photothermal and photodynamic cancer therapies are discussed, highlighting crucial challenges, advantages, future perspectives.
Language: Английский
Citations
23
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3432 - 3456
Published: May 13, 2024
The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.
Language: Английский
Citations
23
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 504 - 504
Published: April 23, 2024
Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.
Language: Английский
Citations
21
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 677 - 677
Published: May 24, 2024
Nanotechnology has emerged as a transformative force in oncology, facilitating advancements site-specific cancer therapy and personalized oncomedicine. The development of nanomedicines explicitly targeted to cells represents pivotal breakthrough, allowing the precise interventions. These cancer-cell-targeted operate within intricate milieu tumour microenvironment, further enhancing their therapeutic efficacy. This comprehensive review provides contemporary perspective on precision medicine underscores critical role nanotechnology advancing It explores categorization nanoparticle types, distinguishing between organic inorganic variants, examines significance delivery anticancer drugs. Current insights into strategies for developing actively across various types are also provided, thus addressing relevant challenges associated with drug barriers. Promising future directions nanomedicine approaches delivered, emphasising imperative continued optimization nanocarriers medicine. discussion translational research’s need enhance patients’ outcomes by refining nanocarrier technologies nanotechnology-driven, therapy.
Language: Английский
Citations
19
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 197, P. 104351 - 104351
Published: April 12, 2024
Breast cancer is potentially a lethal disease and leading cause of death in women. Chemotherapy radiotherapy are the most frequently used treatment options. Drug resistance advanced breast limits therapeutic output treatment. The endocrine hormonal imbalance, particularly triple negative HER2 positive cancers. efflux drugs due to p-gp's activity another resistance. resistant protein also contributes significantly. Strategies combat include use nanoparticles target drug delivery by co-delivery chemotherapeutic genes (siRNA miRNA) that help down-regulate causing siRNA specific effectively silences p-gp other proteins chemosensitizers effective overcoming Chemo-sensitizers sensitize cells effects drugs. Novel anti-neoplastic agents such as antibody-drug conjugates mesenchymal stem tools improve response cancer. Similarly, combination photo/thermal ablation with chemotherapy can act overcome In this review, we focus on mechanism nanoparticle-based strategies
Language: Английский
Citations
18
Smart Medicine, Journal Year: 2024, Volume and Issue: 3(1)
Published: Jan. 30, 2024
Cancer remains a major global health threat necessitating the multipronged approaches for its prevention and management. Traditional in form of chemotherapy, surgery, radiotherapy are often encountered with poor patient outcomes evidenced by high mortality morbidity, compelling need precision medicine cancer patients to enable personalized targeted treatment. There has been an emergence smart multimodal theranostic nanoformulation triple combination therapy last few years, which dramatically enhances overall safety vivo potential clinical applications minimal toxicity. However, it is imperative gain insight into limitations this system terms translation, cost-effectiveness, accessibility, multidisciplinary collaboration. This review paper aims highlight compare impact recent nanoformulations therapeutics single nanocarrier effective management provide new dimension diagnostic treatment simultaneously.
Language: Английский
Citations
16