Breast cancer: pathogenesis and treatments

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 18, 2025

Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.

Language: Английский

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Emerging mechanisms and promising approaches in pancreatic cancer metabolism

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 1, 2024

Abstract Pancreatic cancer is an aggressive with a poor prognosis. Metabolic abnormalities are one of the hallmarks pancreatic cancer, and cells can adapt to biosynthesis, energy intake, redox needs through metabolic reprogramming tolerate nutrient deficiency hypoxic microenvironments. use glucose, amino acids, lipids as maintain malignant growth. Moreover, they also metabolically interact in tumour microenvironment change cell fate, promote progression, even affect immune responses. Importantly, changes at body level deserve more attention. Basic research clinical trials based on targeted therapy or combination other treatments full swing. A comprehensive in-depth understanding regulation will not only enrich mechanisms disease progression but provide inspiration for new diagnostic therapeutic approaches.

Language: Английский

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Co-assembly strategies of natural plant compounds for improving their bioavailability

Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(2), P. 9420022 - 9420022

Published: July 18, 2024

Language: Английский

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The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 329 - 329

Published: Jan. 31, 2025

Nutrition, the gut microbiota and immunity are all important factors in maintenance of health. However, there is a growing realization complex interplay between these elements coalescing nutrition-gut microbiota-immunity axis. This regulatory axis critical for health with disruption being implicated broad range diseases, including autoimmune disorders, allergies mental disorders. new perspective continues to underpin number innovative therapeutic strategies targeting different this treat relevant diseases. review describes inter-relationships nutrition, immunity. It then details several human diseases where has been identified presents examples how various may be targeted therapeutically as alternate treatment

Language: Английский

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Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156188 - 156188

Published: March 1, 2025

Language: Английский

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High Fat Diet and Polycystic Ovary Syndrome (PCOS) in Adolescence: An Overview of Nutritional Strategies

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 938 - 938

Published: March 24, 2024

Polycystic ovary syndrome (PCOS) is a multifaceted and heterogeneous disorder, linked with notable reproductive, metabolic, psychological outcomes. During adolescence, key components of PCOS treatment involve weight loss achieved through lifestyle dietary interventions, subsequently pursued by pharmacological or surgical therapies. Nutritional interventions represent the first-line therapeutic approach in adolescents affected PCOS, but different kinds protocols exist, so it necessary to clarify effectiveness benefits most well-known nutritional approaches. We provided comprehensive review current literature concerning definition, pathophysiology, options, highlighting strategies, particularly those related high-fat diets. The proposed literature, such as ketogenic diet (KD), appear provide patients terms control metabolic parameters. Among types KD studies, very low-calorie diets (VLCKD), can be considered an effective intervention for short-term PCOS. It rapidly leads alongside improvements body composition profile. Even though extremely advantageous, long-term adherence limiting factor. Indeed, this regimen could become unsustainable due important restrictions required ketosis development. Thus, combination more nutrient-rich regimens, Mediterranean diet, amplify positive effects individuals

Language: Английский

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Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

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The Impact of Maternal Chronic Inflammatory Conditions on Breast Milk Composition: Possible Influence on Offspring Metabolic Programming

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 387 - 387

Published: Jan. 22, 2025

Breastfeeding is the best way to provide newborns with crucial nutrients and produce a unique bond between mother child. Breast milk rich in nutritious non-nutritive bioactive components, such as immune cells, cytokines, chemokines, immunoglobulins, hormones, fatty acids, other constituents. Maternal effects during gestation lactation can alter these influencing offspring outcomes. Chronic inflammatory maternal conditions, obesity, diabetes, hypertension, impact breast composition. from obese mothers exhibits changes fat content, cytokine levels, hormonal concentrations, potentially affecting infant growth health. Similarly, diabetes alters composition of milk, impacting factors metabolic markers. Other pro-inflammatory dyslipidemia syndrome, have been barely studied. Thus, altered tension parameters described modifying its macronutrients important biomolecules, likely offspring’s weight. This review emphasizes chronic conditions on potential implications for development through revision full-access original articles.

Language: Английский

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Editorial for Special Issue: “Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment”

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 160 - 160

Published: Feb. 27, 2025

Metabolic-dysfunction-associated fatty liver disease (MAFLD) and alcohol-associated (ALD) represent two of the most prevalent chronic diseases globally, collectively affecting hundreds millions individuals [...]

Language: Английский

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Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2262 - 2262

Published: July 13, 2024

There is currently a growing interest in diets and physical activity patterns that may be beneficial preventing treating breast cancer (BC). Mounting evidence indicates indeed, the so-called Mediterranean diet (MedDiet) regular likely both help reduce risk of developing BC. For those who have already received BC diagnosis, these interventions decrease tumor recurrence after treatment improve quality life. Studies also show potential other dietary interventions, including fasting or modified fasting, calorie restriction, ketogenic diets, vegan plant-based to enhance efficacy therapies. In this review article, we discuss biological rationale for utilizing prevention treatment. We highlight published ongoing clinical studies applied lifestyle patients. This offers valuable insights into application as complimentary therapies management.

Language: Английский

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