Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 1841 - 1841
Published: March 9, 2025
Background:
Metabolic-dysfunction-associated
steatotic
liver
disease
(MASLD)
and
heart
failure
are
two
intersecting
growing
pandemics.
Studies
have
demonstrated
a
strong
association
between
MASLD
failure.
Liver
cirrhosis
is
well-recognized
complication
of
MASLD.
This
study
aimed
to
summarize
the
potential
effects
Ramadan
fasting
on
MASLD,
cirrhosis,
The
author
searched
SCOPUS
PubMed
databases
using
specific
terms.
literature
review
focused
research
articles
published
in
English
from
2000
2024.
Twenty-two
were
selected
for
this
narrative
review.
reduced
serum
cholesterol
levels,
improved
symptoms
anthropometric
measurements.
However,
it
increased
ascitic
fluid
production
plasma
bilirubin
levels
might
increase
risk
hepatic
encephalopathy
upper
gastrointestinal
haemorrhage
cirrhosis.
improve
decrease
patients
with
Further
studies
needed
confirm
efficacy
evaluate
safety
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Feb. 18, 2025
Abstract
Breast
cancer,
characterized
by
unique
epidemiological
patterns
and
significant
heterogeneity,
remains
one
of
the
leading
causes
malignancy-related
deaths
in
women.
The
increasingly
nuanced
molecular
subtypes
breast
cancer
have
enhanced
comprehension
precision
treatment
this
disease.
mechanisms
tumorigenesis
progression
been
central
to
scientific
research,
with
investigations
spanning
various
perspectives
such
as
tumor
stemness,
intra-tumoral
microbiota,
circadian
rhythms.
Technological
advancements,
particularly
those
integrated
artificial
intelligence,
significantly
improved
accuracy
detection
diagnosis.
emergence
novel
therapeutic
concepts
drugs
represents
a
paradigm
shift
towards
personalized
medicine.
Evidence
suggests
that
optimal
diagnosis
models
tailored
individual
patient
risk
expected
are
crucial,
supporting
era
oncology
for
cancer.
Despite
rapid
advancements
increasing
emphasis
on
clinical
comprehensive
update
summary
panoramic
knowledge
related
disease
needed.
In
review,
we
provide
thorough
overview
global
status
including
its
epidemiology,
factors,
pathophysiology,
subtyping.
Additionally,
elaborate
latest
research
into
contributing
progression,
emerging
strategies,
long-term
management.
This
review
offers
valuable
insights
Cancer
Research,
thereby
facilitating
future
progress
both
basic
application.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(8)
Published: Aug. 1, 2024
Abstract
Pancreatic
cancer
is
an
aggressive
with
a
poor
prognosis.
Metabolic
abnormalities
are
one
of
the
hallmarks
pancreatic
cancer,
and
cells
can
adapt
to
biosynthesis,
energy
intake,
redox
needs
through
metabolic
reprogramming
tolerate
nutrient
deficiency
hypoxic
microenvironments.
use
glucose,
amino
acids,
lipids
as
maintain
malignant
growth.
Moreover,
they
also
metabolically
interact
in
tumour
microenvironment
change
cell
fate,
promote
progression,
even
affect
immune
responses.
Importantly,
changes
at
body
level
deserve
more
attention.
Basic
research
clinical
trials
based
on
targeted
therapy
or
combination
other
treatments
full
swing.
A
comprehensive
in-depth
understanding
regulation
will
not
only
enrich
mechanisms
disease
progression
but
provide
inspiration
for
new
diagnostic
therapeutic
approaches.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 329 - 329
Published: Jan. 31, 2025
Nutrition,
the
gut
microbiota
and
immunity
are
all
important
factors
in
maintenance
of
health.
However,
there
is
a
growing
realization
complex
interplay
between
these
elements
coalescing
nutrition-gut
microbiota-immunity
axis.
This
regulatory
axis
critical
for
health
with
disruption
being
implicated
broad
range
diseases,
including
autoimmune
disorders,
allergies
mental
disorders.
new
perspective
continues
to
underpin
number
innovative
therapeutic
strategies
targeting
different
this
treat
relevant
diseases.
review
describes
inter-relationships
nutrition,
immunity.
It
then
details
several
human
diseases
where
has
been
identified
presents
examples
how
various
may
be
targeted
therapeutically
as
alternate
treatment
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(7), P. 938 - 938
Published: March 24, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
multifaceted
and
heterogeneous
disorder,
linked
with
notable
reproductive,
metabolic,
psychological
outcomes.
During
adolescence,
key
components
of
PCOS
treatment
involve
weight
loss
achieved
through
lifestyle
dietary
interventions,
subsequently
pursued
by
pharmacological
or
surgical
therapies.
Nutritional
interventions
represent
the
first-line
therapeutic
approach
in
adolescents
affected
PCOS,
but
different
kinds
protocols
exist,
so
it
necessary
to
clarify
effectiveness
benefits
most
well-known
nutritional
approaches.
We
provided
comprehensive
review
current
literature
concerning
definition,
pathophysiology,
options,
highlighting
strategies,
particularly
those
related
high-fat
diets.
The
proposed
literature,
such
as
ketogenic
diet
(KD),
appear
provide
patients
terms
control
metabolic
parameters.
Among
types
KD
studies,
very
low-calorie
diets
(VLCKD),
can
be
considered
an
effective
intervention
for
short-term
PCOS.
It
rapidly
leads
alongside
improvements
body
composition
profile.
Even
though
extremely
advantageous,
long-term
adherence
limiting
factor.
Indeed,
this
regimen
could
become
unsustainable
due
important
restrictions
required
ketosis
development.
Thus,
combination
more
nutrient-rich
regimens,
Mediterranean
diet,
amplify
positive
effects
individuals
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1062 - 1062
Published: Aug. 30, 2024
Neurodegenerative
diseases
encompass
a
spectrum
of
disorders
marked
by
the
progressive
degeneration
structure
and
function
nervous
system.
These
conditions,
including
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
Amyotrophic
lateral
sclerosis
(ALS),
Multiple
(MS),
often
lead
to
severe
cognitive
motor
deficits.
A
critical
component
neurodegenerative
pathologies
is
imbalance
between
pro-oxidant
antioxidant
mechanisms,
culminating
in
oxidative
stress.
The
brain's
high
oxygen
consumption
lipid-rich
environment
make
it
particularly
vulnerable
damage.
Pro-oxidants
such
as
reactive
nitrogen
species
(RNS)
(ROS)
are
continuously
generated
during
normal
metabolism,
counteracted
enzymatic
non-enzymatic
defenses.
In
diseases,
this
balance
disrupted,
leading
neuronal
This
systematic
review
explores
roles
stress,
gut
microbiota,
epigenetic
modifications
aiming
elucidate
interplay
these
factors
identify
potential
therapeutic
strategies.
We
conducted
comprehensive
search
articles
published
2024
across
major
databases,
focusing
on
studies
examining
relationships
redox
homeostasis,
changes
neurodegeneration.
total
161
were
included,
comprising
clinical
trials,
observational
studies,
experimental
research.
Our
findings
reveal
that
stress
plays
central
role
pathogenesis
with
microbiota
composition
significantly
influencing
balance.
Specific
bacterial
taxa
markers
identified
modulators
suggesting
novel
avenues
for
intervention.
Moreover,
recent
evidence
from
human
animal
supports
emerging
concept
targeting
homeostasis
through
therapies.
Future
research
should
focus
validating
targets
settings
exploring
personalized
medicine
strategies
based
individual
profiles.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 387 - 387
Published: Jan. 22, 2025
Breastfeeding
is
the
best
way
to
provide
newborns
with
crucial
nutrients
and
produce
a
unique
bond
between
mother
child.
Breast
milk
rich
in
nutritious
non-nutritive
bioactive
components,
such
as
immune
cells,
cytokines,
chemokines,
immunoglobulins,
hormones,
fatty
acids,
other
constituents.
Maternal
effects
during
gestation
lactation
can
alter
these
influencing
offspring
outcomes.
Chronic
inflammatory
maternal
conditions,
obesity,
diabetes,
hypertension,
impact
breast
composition.
from
obese
mothers
exhibits
changes
fat
content,
cytokine
levels,
hormonal
concentrations,
potentially
affecting
infant
growth
health.
Similarly,
diabetes
alters
composition
of
milk,
impacting
factors
metabolic
markers.
Other
pro-inflammatory
dyslipidemia
syndrome,
have
been
barely
studied.
Thus,
altered
tension
parameters
described
modifying
its
macronutrients
important
biomolecules,
likely
offspring’s
weight.
This
review
emphasizes
chronic
conditions
on
potential
implications
for
development
through
revision
full-access
original
articles.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(3), P. 160 - 160
Published: Feb. 27, 2025
Metabolic-dysfunction-associated
fatty
liver
disease
(MAFLD)
and
alcohol-associated
(ALD)
represent
two
of
the
most
prevalent
chronic
diseases
globally,
collectively
affecting
hundreds
millions
individuals
[...]
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2262 - 2262
Published: July 13, 2024
There
is
currently
a
growing
interest
in
diets
and
physical
activity
patterns
that
may
be
beneficial
preventing
treating
breast
cancer
(BC).
Mounting
evidence
indicates
indeed,
the
so-called
Mediterranean
diet
(MedDiet)
regular
likely
both
help
reduce
risk
of
developing
BC.
For
those
who
have
already
received
BC
diagnosis,
these
interventions
decrease
tumor
recurrence
after
treatment
improve
quality
life.
Studies
also
show
potential
other
dietary
interventions,
including
fasting
or
modified
fasting,
calorie
restriction,
ketogenic
diets,
vegan
plant-based
to
enhance
efficacy
therapies.
In
this
review
article,
we
discuss
biological
rationale
for
utilizing
prevention
treatment.
We
highlight
published
ongoing
clinical
studies
applied
lifestyle
patients.
This
offers
valuable
insights
into
application
as
complimentary
therapies
management.