Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
16(3), P. 700 - 707
Published: Dec. 31, 2024
Developing
new
drug
delivery
systems
is
crucial
for
enhancing
the
efficacy
of
oncolytic
virus
(OV)
therapies
in
cancer
treatment.
In
this
study,
mesenchymal
stem
cell
(MSC)-derived
vesicles
and
viruses
are
exploited
to
construct
a
novel
formulation.
It
has
been
hypothesized
that
vesicle-coated
OVs
could
amplify
cytotoxic
effects
through
superior
internalization
by
tumor
cells.
MSC
possess
natural
homing
ability
biocompatibility,
which
can
enhance
targeting,
uptake,
therapeutic
on
Experimental
results
indicated
treatment
system
increased
apoptosis
Furthermore,
flow
cytometry
analysis
demonstrated
uptake
cells
coated
with
soared
away
compared
uncoated
OVs,
being
1.5
times
than
group.
Additionally,
confocal
laser
scanning
microscopy
also
showed
fluorescence
intensity
within
pretreated
MSC-coated
was
greater.
Meanwhile,
propidium
iodide
(PI)
staining
revealed
Ovs
exposed
accelerating
latter.
According
statistics,
number
dead
increased,
testified
OV
group
as
high
23.78%.
These
findings
highlight
potential
therapy,
providing
promising
strategy
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Extracellular
vesicles
(EVs)
are
critical
mediators
of
intercellular
communication,
carrying
bioactive
cargo
and
displaying
diverse
surface
components
that
reflect
their
cellular
origins
functions.
The
EV
surface,
composed
proteins,
lipids,
glycocalyx
elements,
plays
a
pivotal
role
in
targeting
recipient
cells,
mediating
biological
interactions,
enabling
selective
delivery.
This
review
comprehensively
examined
the
molecular
architecture
surfaces,
linking
biogenesis
to
functional
diversity,
highlights
therapeutic
diagnostic
potential
diseases
such
as
cancer
cardiovascular
disorders.
Additionally,
we
explore
emerging
applications
EVs,
including
machine-learning-assisted
analysis,
chemical
integration,
cross-system
combinations.
also
discusses
some
key
challenges
clinical
translation
EV-related
technologies.
Molecular Biomedicine,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Nov. 21, 2024
Abstract
Extracellular
vesicles
(EVs)
are
cell-derived
with
a
phospholipid
bilayer
measuring
50–150
nm
in
diameter
demonstrated
therapeutic
potentials.
Limitations
such
as
the
natural
biodistribution
(mainly
concentrated
liver
and
spleen)
short
plasma
half-life
of
EVs
present
significant
challenges
to
their
clinical
translation.
In
recent
years,
growing
research
indicated
that
engineered
enhanced
targeting
lesion
sites
have
markedly
promoted
efficacy.
However,
there
is
dearth
systematic
knowledge
on
advances
engineering
for
targeted
delivery.
Herein,
we
provide
an
overview
mechanisms,
techniques,
translations
applications.
Enrichment
at
may
be
achieved
through
recognition
tissue
markers,
pathological
changes,
circumvention
mononuclear
phagocyte
system
(MPS).
Alternatively,
external
stimuli,
including
magnetic
fields
ultrasound,
also
employed.
EV
techniques
fulfill
functions
includes
genetic
engineering,
membrane
fusion,
chemical
modification
physical
modification.
A
comparative
statistical
analysis
was
conducted
elucidate
discrepancies
between
diverse
size,
morphology,
stability,
efficacy
vitro
vivo.
Additionally,
summary
registered
trials
utilizing
from
2010
2023
has
been
provided,
full
discussion
perspectives.
This
review
provides
comprehensive
mechanisms
associated
delivery
applications
advocate
further
explorations
accelerate
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Abstract
Extracellular
vesicles
(EVs)
have
emerged
as
promising
bioactive
carriers
for
delivering
therapeutic
agents,
including
nucleic
acids,
proteins,
and
small‐molecule
drugs,
owing
to
their
excellent
physicochemical
stability
biocompatibility.
However,
comprehensive
reviews
on
the
various
types
of
EV‐based
nanomedicines
cancer
therapy
remain
scarce.
This
review
explores
potential
EVs
antitumor
nanomedicines.
Methods
EV
extraction,
drug
loading,
engineering
modifications
are
systematically
examined,
strengths
limitations
these
technical
approaches
critically
assessed.
Additionally,
key
strategies
developing
therapies
highlighted.
Finally,
opportunities
challenges
associated
with
advancing
toward
clinical
translation
discussed.
With
integration
multiple
disciplines,
robust
platforms
expected
be
manufactured
provide
more
personalized
effective
solutions
oncology
patients.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 3379 - 3406
Published: March 1, 2025
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
one
of
the
deadliest
cancers
in
world,
mainly
because
its
powerful
pro-connective
tissue
proliferation
matrix
and
immunosuppressive
tumor
microenvironment
(TME),
which
promote
progression
metastasis.
In
addition,
extracellular
leads
to
vascular
collapse,
increased
interstitial
fluid
pressure,
obstruction
lymphatic
return,
thereby
hindering
effective
drug
delivery,
deep
penetration,
immune
cell
infiltration.
Therefore,
reshaping
TME
enhance
perfusion,
increase
reverse
suppression
has
become
a
key
therapeutic
strategy.
Traditional
therapies
for
PDAC,
including
surgery,
radiation,
chemotherapy,
face
significant
limitations.
Surgery
challenging
due
location
growth,
while
chemotherapy
radiation
are
hindered
by
dense
TME.
recent
years,
advancement
nanotechnology
provided
new
opportunities
improve
efficacy.
Nanoscale
delivery
systems
(NDDSs)
provide
several
advantages,
improved
stability
vivo,
enhanced
reduced
systemic
toxicity.
However,
clinical
translation
PDAC
therapy
faces
challenges.
These
include
need
precise
targeting
control
over
release,
potential
responses
nanocarriers,
scalability
cost-effectiveness
production.
This
article
provides
an
overview
latest
nanobased
methods
achieving
better
outcomes
overcoming
resistance.
We
pay
special
attention
TME-targeted
context
discuss
advantages
limitations
current
strategies,
emphasize
promising
developments.
By
emphasizing
enormous
NDDSs
improving
treatment
patients
with
critically
discussing
traditional
challenges
faced
breakthroughs,
our
review
paves
way
future
research
this
rapidly
developing
field.
