Diabetes Metabolic Syndrome and Obesity,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1563 - 1574
Published: May 1, 2025
Type
2
diabetes
mellitus
(T2DM)
is
a
complex
clinical
syndrome
characterized
by
insulin
resistance
and
associated
with
abnormal
amino
acid
metabolism.
Tryptophan
an
aromatic
dietary
that
affects
T2DM
regulating
glycolipid
metabolism
resistance.
When
tryptophan
reaches
the
intestine,
it
converted
gut
microbiota
tryptophanase
into
indole
derivatives
such
as
indoleacetic
acid,
indolepropionic
indolealdehyde.
These
may
enhance
sensitivity,
stimulate
secretion,
exert
functions
lowering
blood
glucose,
hepatic
oxidative
stress,
reducing
intestinal
inflammation,
improving
islet
cell
morphology
acting
on
aryl
hydrocarbon
receptor
(AHR)
or
Pregnane
X
(PXR).
In
summary,
this
review
aims
to
examine
interactions
between
thoroughly,
elucidate
potential
therapeutic
approaches,
pinpoint
areas
for
further
research.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 28, 2025
IgA
nephropathy
(IgAN)
is
related
to
the
balance
of
gut
microbiota.
However,
it
unclear
whether
changes
in
microbiota
can
cause
IgAN
or
attenuate
its
progression.
This
study
employed
and
human
microbiota-associated
(HMA)-IgAN
models
investigate
impact
on
alteration
mechanisms
by
which
might
trigger
IgAN.
Furthermore,
this
examined
effects
chitooligosaccharides
(COS)
COS
formulation
(COSF)
with
microbiota-targeting
function
enhancing
intestinal
barrier
renal
functions.
These
results
revealed
that
led
a
reduction
α-diversity
structural
alterations
microbiota,
characterized
an
increase
Shigella
sonnei,
Streptococcus
danieliae,
Desulfovibrio
fairfieldensis,
decrease
Bifidobacterium
pseudolongum
Clostridium
leptum.
There
was
also
imbalance
B-cell
immunity
level
tight
junction
proteins
(ZO-1
Occludin).
Intestinal
mucosal
immune-related
(Clostridium
leptum,
unclassified
Lachnospiraceae
NK4Al36
group,
Clostridia
vadinBB60
Oscillospiraceae,
Roseburia)
were
enriched
through
targeted
modulation
COS/COSF,
ZO-1
expression
reducing
APRIL/BAFF
overexpression,
thereby
damage
In
conclusion,
clarified
kidney-gut
crosstalk
between
IgAN,
providing
scientific
evidence
for
developing
microbiota-targeted
food
interventions
improve
outcomes.
Cellular and Molecular Life Sciences,
Journal Year:
2024,
Volume and Issue:
81(1)
Published: Dec. 1, 2024
Gut
microbiota
is
a
complex
and
dynamic
system
that
plays
critical
roles
in
human
health
various
disease.
Progressive
chronic
kidney
disease
(CKD)
suggests
patients
irreversibly
progress
to
end-stage
need
renal
replacement
treatments,
including
dialysis
transplantation.
Ample
evidence
indicates
local
oxidative
stress
inflammation
play
pivotal
the
pathogenesis
progression
of
CKD
dysbiosis
gut
microbiota.
always
accompanied
by
intestinal
stress,
which
lead
rapid
systemic
translocation
bacterial-derived
uraemic
toxins,
indoxyl
sulphate,
phenyl
sulphate
indole-3-acetic
acid,
consequent
development
aggravation
fibrosis.
Although
have
been
extensively
discussed,
there
paucity
reports
on
effects
fibrosis
mediation
inflammation.
This
review
provides
an
overview
fibrosis,
briefly
discusses
regulation
flora
using
microecological
preparations
natural
products,
such
as
resveratrol,
curcumin
emodin
treatments
for
CKD,
clear
pathophysiological
rationale
design
promising
therapeutic
strategies.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 14, 2025
Objective
Chronic
kidney
disease
(CKD)
is
a
major
global
health
problem.
In
clinical
practice,
the
Chinese
patent
herbal
medicine
Jianpi-Yishen
(JPYS)
formula
commonly
used
to
treat
CKD.
However,
molecular
mechanisms
by
which
JPYS
targets
and
modulates
host
immune
response
remain
unclear.
Methods
This
study
utilized
network
pharmacology,
RNA
sequencing
(RNA-seq),
metabolic
analyses
using
in
vivo
vitro
models
investigate
impact
of
on
inflammation
system.
Specifically,
focused
macrophage
polarization
changes
that
may
slow
down
progression
Results
A
total
14,946
CKD-related
were
identified
from
GeneCards
Online
Mendelian
Inheritance
Man
(OMIM)
databases
through
pharmacology
analyses.
227
potential
predicted
TCMSP
database.
Additionally,
diagram
demonstrated
11
associated
with
activity.
studies
indicated
could
reduce
blood
urea
nitrogen
serum
creatinine
adenine-induced
CKD
rats.
Furthermore,
inhibited
inflammatory
damage
abnormal
infiltration
this
model.
RNA-seq,
proteomic
regulation
amino
acid
metabolism
betaine,
specifically
referring
glycine,
serine,
threonine
metabolism,
as
key
target
slowing
addition,
suggested
enhance
tryptophan
M1
betaine
M2
polarization.
Conclusions
The
has
been
shown
have
beneficial
CKD;
mechanism
mitigation
interaction
between
Of
specific
importance
context
are
roles
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
Patients
with
chronic
kidney
disease
(CKD)
are
at
a
high
risk
of
developing
secondary
hyperparathyroidism
(SHPT),
which
may
cause
organ
dysfunction
and
increase
patient
mortality.
The
main
clinical
interventions
for
CKD–SHPT
involve
calcium
supplements
to
boost
absorption,
but
ineffective
some
patients,
the
reasons
remain
unclear.
Here,
CKD
mice
divided
into
low
groups
based
on
intact
parathyroid
hormone
(iPTH)
levels.
group
exhibits
significant
changes
in
gut
microbes,
including
decrease
Lactobacillus
,
an
hyperplasia,
intestinal
calcium.
Fecal
microbiota
transplantation
L.
johnsonii
colonization
indicate
link
between
microbes
CKD–SHPT.
Clinically,
higher
levels
correlated
milder
receiver
operating
characteristic
(ROC)
curve
abundance
surgical
is
0.81,
calibration
confirming
predictive
accuracy,
decision
analysis
revealing
good
applicability.
In
vivo
vitro
experiments
show
that
cyclo(pro‐trp)
enhance
inflow
lower
iPTH
epithelial
cells
via
calcium‐sensing
receptor
transient
potential
vanilloid
4
pathways.
This
study
identified
crucial
role
CKD–SHPT,
unveiling
new
mechanism
imbalance
offering
novel
strategies
SHPT
treatment
drug
development.
